Ngokucacileyo,IArgireline ikwabizwa ngokuba yiAcetyl Hexapeptide-8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) kunye ne-acetyl hexapeptide 3
Ngokuthe ngqo,I-Argireline yi-peptide yokwenziwa olandelelwano luthathwe kwi- N-isiphelo ummandla we SNAP-25 iprotheni.
Ngokubanzi,I-Argireline inendlela efanayo yokwenza i-toxin ye-botulinum(Botox kwibhotile), ukufezekisa ukulwa nokuguga kunye nokunciphisa imiphumo yemibimbi ngokuthintela ukukhululwa kwe i-neurotransmitter e ukuhlangana kwe-neuromuscular. Njenge-peptide ye-cosmetic bioactive eqhelekileyo,Uphononongo lweklinikhi lubonise ukuba iArgireline inokunciphisa ubunzulu bokushwabana kwesikhumba, ukuphucula ukunwebeka kwesikhumba, kunye nokwandisa amanzi.
Ulandelelwano
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Inombolo yeCAS
616204-22-9
Ifomula yeemolekyuli
I-C34H60N14O12S
Ubunzima beMolekyuli
889 g/mol
1.Yintoni iArgireline
I-Argireline yaphuhliswa njengenye indlela yokuphumelela kwitoksi ye-botulinum. Nangona kunjalo, ngokungafaniyo netyhefu ye-botulinum (“Botox kwibhotile”), efuna inaliti engaphantsi kwesikhumba, I-Argireline isebenza ngokusetyenziswa kwezihloko kwi i-epidermis, kuthintelwa imingcipheko eyayanyaniswa neenaliti ezingaphantsi kwesikhumba.
Embindini wayo, IArgireline iphazamisana ne i-neurotransmitter khulula ngokujolisa kwi SNARE complex (i-soluble NSF attachment protein receptor),nto leyo ibalulekile xa kusenziwa idocking iacetylcholine equlathe iivesicles.Ngale ndlela, iphazamisa ukubunjwa kwe-SNARE kunye nokuzinza, ngaloo ndlela inqanda ukukhutshwa kwe-neurotransmitter.
Ukwakhiwa kolu matshini, ngokukodwa, izazinzulu zenze i-Argireline kwisakhiwo se-N-terminus ye-SNAP-25 protein . Ikhuphisana ne-SNAP-25 yokubopha kwi Iprotheni ye-membrane ehambelana ne-vesicle (VAMP/synaptobrevin).Le teknoloji ye-peptide iphazamisa ukubunjwa kwe-SNARE complex, ngaloo ndlela inqanda neuronal exocytosis [1].
2.IiNzuzo zeArgireline：
I-Argireline ibonelela ngonyamezelo olulungileyo kunye nokungaphangi.Ngokukodwa,iinzuzo eziphambili ziquka:
(1).Ukunciphisa i-Facial Muscle Contraction
I-Argireline inciphisa ukubonakala kwemigca yokubonakalisa(njengemibimbi ebunzi kunye neenyawo zikagwayi) ngokuthintela ukukhululwa kwe-acetylcholine ngexesha le-exocytosis, ethintela ukufinyela kwemisipha. Umzekelo,Izifundo zeklinikhi zibonise ukuba 10% i-argireline serum inokunciphisa ubunzulu bokushwabana[2] nge 30% emva 30 iintsuku kwi vivo.
(2).Ukuphuculwa koLusu oluThunyiweyo kunye nokuButheka
Uphononongo lweklinikhi lubonise ukuba ukusebenzisa ukwakheka okuqulathe 10% i-acetyl hexapeptide-8 kwisikhumba sobuso yonke imihla 20 iintsuku zinokunciphisa kancinci uburhabaxa bolusu kwaye zinciphise ilahleko yamanzi e-transepidermal (I-TEWL) [3] .Ngaphaya koko,emva 4 iiveki, ukwakheka kunciphise ubunzulu bombimbi 49% [4] .
(3).UkuPhuculwa kweScar kunye nesiphako
Ngokulinganayo kubalulekile, kulingo lwezonyango nge 26 izigulana ezinobunzima, Ijeli ye-Argireline ye-topical ibonisiwe:
- Ukuqina kwesikhumba kwindawo ephathwayo kwanda kakhulu.
- Amanqanaba okufakwa kwamanzi ehle kancinci
- Imveliso ye-sebum kwindawo ebomvu yehle kakhulu xa kuthelekiswa nendawo ejikelezileyo.
Okona kubalulekileyo, ngaphambi nangemva kweefoto zonyango zibonise ukuphucuka okuphawulekayo kwizibazi ezibangelwa ukungenelela kotyando olunxulumene nonyango lomhlaza, ukususwa kwe-cyst, okanye ukususwa kwe-mole.
3.Ukuqukumbela
Ngokudibeneyo,I-Argireline yi-peptide ye-bioactive eqinisekisiwe ngokwesayensi kunye nenkqubo ecacileyo yokusebenza. Ngokulinganisa indlela yesenzo se-toxin ye-botulinum(“Botox kwibhotile”), abantu banokuyisebenzisa ngokwezihloko,ngokukhuselekileyo nangokufanelekileyo ukuphumla ngokucokisekileyo ukufinyela kwemisipha, ngokufanelekileyo ukunciphisa imigca yokubonakalisa kunye nokuphucula ukuthungwa kwesikhumba [5] .
I-COA
HPLC
NKSK
