I-Pancragen yi-peptide yokwenziwa kwe-bioactive eyenziwe ngee-amino acids ezine.
Uphando malunga nokusebenza kwepancreatic lukhokelele izazinzulu ukuba zifumanise a ihomoni-njengenxalenye esebenzayo ngaphakathi kwi-pancreatic extracts; ukuvuselela i-pancreas ngokwayo ibe yeyona nto iphambili ephawulweyo.
Ukwakhiwa ngokuthe ngqo kwale hormone ekuqaleni kwakungacacanga.
Ukuqhubela phambili kwi ibhayoloji yemolekyuli kwaye emva koko itekhnoloji ye-peptide synthesis yavumela uphindaphindo lwayo oluchanekileyo – ukuphuculwa okuqhubekayo kunye nokuguqulwa okujoliswe kuko kweqhekeza elingundoqo ukusuka kwisicatshulwa sokuqala yindlela eyayenziwe ngayo iPancragen.
I-post-synthesis, Ixabiso elibalulekileyo lophando lweklinikhi libalelwa kulo.
Ukuphucula ukuzinza kwezicubu ze-pancreatic, ukukhuthaza ukulungiswa, kunye nokulawula i-homeostasis yemetabolism ziinzuzo zayo eziphambili ezibhalwe kakuhle.
Banzi anti-ukudumba kunye neziphumo zokukhusela zibonwa ngaphakathi kwesibindi, izintso, inkqubo ye-nervous kunye namanye amalungu.
Ulandelelwano
H2N-Lys-Glu-Asp-Trp-OH
Inombolo yeCAS
/
Ifomula yeemolekyuli
I-C26H36N6O9
Ubunzima beMolekyuli
576.607
Uphando lwePancragen Peptide
1.Ukukhuselwa kunye noHlaziyo lwe Iiseli ze-β zePancreatic
Ukuncipha kwezi seli yeyona nto iphambili ye-pathological factor isifo seswekile.
Ukulinganisa imiba engapheliyo yokukhula okanye imiqondiso yokusinda, Ukuvinjelwa kwe-apoptosis yindlela ephambili; ukukhusela (noko okwethutyana) iiseli ze-beta kunye nokudala i-microenvironment exhasayo yokuvuselelwa kweeseli.
Izinga leglucose yegazi elizinzileyo ligcinwa, ngokungathanga ngqo ngokuphuculwa kwezicubu ze-peripheral uvakalelo lwe-insulin – ukunciphisa imiba eyahlukeneyo ye-insulin ukumelana kunye nokuphucula umsebenzi wemitochondrial.
I-Pancragen yenza ezo ndlela zokusinda zikhankanywe ngaphambili (PI3K/Act kwaye I-MAPK/ERK).
Ukuqalisa iindlela ze-apoptotic phantsi kohlaselo oluvuthayo luvinjelwe ngempumelelo.
Ulingo lwezonyango kungoku nje luphanda uhlaziyo lwenene lweselula njengendawo yokuphela.
Ukuvuselela ukwahlukana kunye nokwanda ubuncinane kweeseli ezithile, kudityaniswe ne-microenvironment ekhankanywe ngaphambili, imele ukuguqulwa okusisiseko kokuqhubela phambili kwesifo seswekile.
2.Ulawulo lweMetabolic (njengoko ngasentla)
Uphuculo olucwangcisiweyo lobuntununtunu kwi-insulin bubonwa kwiimodeli zezilwanyana.
Cytoprotection kunciphisa i-hepatic kunye izicubu ze-adipose ukudumba okungapheliyo.
Iziphumo ezithe ngqo nezingathanga ngqo kwi i-insulin receptor kunye nomsebenzi we-transporter zonke ziyinxalenye yophuculo ngokubanzi kwi-insulin sensitivity.
I-Antioxidant kunye neempembelelo ezichasayo zePancragen zinexabiso elibalulekileyo lophando.
Neuropathy kunye isifo semetabolism uhlobo umonakalo, okanye nasiphi na isifo esinxulumene uxinzelelo lwe-oxidative, unako kwaye kufuneka uzuze kwizicelo zonyango lwePancragen.
I-COA
HPLC
NKSK
