I-Livagen iyi-peptide ye-bioactive phakathi komndeni wakwaKhavinson; Ukulandelana okuqondile kwe-amino acid kunguLys-Glu-Asp-Ala. Ucwaningo lokulwa nokuguga nokuphila isikhathi eside luholele ekutholweni kwayo.
Multidimensional, izakhiwo ezihlosiwe eziningi ziphakathi kwezici zayo eziphawuleka kakhulu. Ukulingisa ama-endogenous signaling molecules, isebenza ngokuqondile kokubili ku-nucleus yeseli kanye i-mitochondria; ukulawulwa kofuzo okunamandla nokuvikelwa kwamaselula kuyimisebenzi ewumphumela.
Ukuphromothwa kwe histone (I-H5 ne-H2A ngokukhethekile) i-acetylation ikhulula izakhi ze-DNA eziboshwe ngokuqinile ezidingekayo ukuze zifaneleke okulotshiweyo.
Izakhi zofuzo ezizuzisayo ezathuliswa ngaphambilini noma ezancishiswa inqubo yokuguga ziyavuselelwa ukuze kubuyiselwe ‘ubusha beselula.’ isimo sokuloba.
Iyathuthukisa i-telomerase umsebenzi kanye nokunciphisa ukuncipha kwe-telomere ngesikhathi sokuhlukaniswa kungenye into ebalulekile.
I-ATP synthesis ithuthukisiwe, amandla metabolism kanye nobungqabavu jikelele ekubeni umkhiqizo wokugcina.
Okunamandla i-antioxidant umsebenzi, uhlelo lwe-neuroendocrine ithonya, ukuzivumelanisa nokucindezeleka kanye nekhwalithi yokulala konke kuthinteka kahle; I-homeostasis iyinhloso yokugcina yesenzo sikaLivagen.
Ukulandelana
H-Lys-Glu-Asp-Ala-OH
Inombolo ye-CAS
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I-Molecular Formula
I-C18H31N5O9
Isisindo samangqamuzana
461.472
Ucwaningo lwe-Livagen Peptide
1.I-Epigenetic Regulation kanye ne-Gene Expression eyalandela
Ukulawulwa kwe-Epigenetic kuyindlela eyinhloko yokusebenza kulo mndeni wama-peptide.
I-Acetylation ama-histones (njengoba kushiwo ngenhla) kuholela ku i-chromatin ukuguqulwa kwesakhiwo kusuka kokufingqiwe kakhulu kuya kokukhululekile euchromatic isimo.
I-RNA polymerase futhi izici zokuloba, bayakwazi ‘ukufinyelela’ izakhi zofuzo ebezingabanjwanga ngaphambilini.
Ukuhlolwa kubonise izakhi zofuzo eziningi ezizuzisayo ezingasasebenzi kumaseli amadala nge-histone deacetylation.
I-Livagen ihlehlisa le nqubo, ukusetha kabusha izinhlelo zokulotshwa, yikho okuchaza amandla ayo okulwa nokuguga.
2.I-Telomere Isondlo
Ukufinyezwa kwama-telomere kuwuphawu lokuguga kwamaselula.
Ukuhlukaniswa kwamaseli ngokwako kubangela lokhu kuncipha, i-apoptosis iyiphoyinti lokugcina uma ama-telomere efinyelela esimweni esifushane kakhulu.
U-Livagen uyabambezela lokhu, futhi ngaleyo ndlela kulondoloza noma andise ukuphila kwengqamuzana nezicubu.
3.Kuthuthukisiwe I-Mitochondrial Umsebenzi kanye ne-Bioenergetics
I-Livagen ithuthukisa ngamandla ukukhiqizwa kwamandla e-mitochondrial.
Ukuthuthukisa ukusebenza kahle kwe-mitochondrial iketango lezokuthutha le-electron kungumnyombo wale nqubo, nge i-adenosine triphosphate (I-ATP) ukuhlanganisa kuba umphumela oqondile.
Amandla eselula amaningi abe esetholakala; isakhiwo samandla jikelele somzimba siyathuthukiswa, ubungqabavu bomzimba obulandela kulesi simo.
Ukucindezela okuyisisekelo kokudlulele, ukukhiqizwa okwenziwa ukucindezeleka kwe izinhlobo ze-oxygen esebenzayo kuyazuzwa – umfutho wemvelo wokugcina ubungqabavu bobusha yisiphetho salo mshini.
4.I-Antioxidant kanye ne-Anti-inflammatory Effects
I-Livagen ilawula izinto ezahlukahlukene ezisebenzayo ze-antioxidant; ukuguqula izinhlobo ze-oxidative eziyingozi zibe izinhlanganisela ezingenangozi kuyisenzo sako esiyinhloko.
Ukuzikhiqiza kwe-Endogenous kuyinzuzo yangempela lapha, exogenous Ama-antioxidant asebenza kahle kuzo zonke izici (ukusebenza kahle, ukuphikelela, ukufinyelela kwesistimu).
Ulwelwesi lwamaseli, amaprotheni, lipids kanye ne-DNA, thola okuphelele, ukuvikelwa kwesikhathi eside kuzo zonke izinhlobo zengcindezi ye-oxidative enqwabelene.
Ukulimala kwamangqamuzana kuncishiswa yilezi zinqubo.
I-COA
I-HPLC
MS
