I-Myristoyl Pentapeptide-8 iyi-peptide yezimonyo ye-bioactive eyenziwe ngokuguqulwa kwamakhemikhali emvelo. ukulandelana kokusayina.
Ukukhula kwezinwele okuyingqayizivele nemisebenzi ehlukahlukene yezimonyo kubangelwa ucezu oluthile lwe-pentapeptide olulondoloziwe., I-Lys-Thr-Thr-Lys-Ser, ethathwe ochungechungeni lwe-α1 lwe thayipha i-procollagen.
Isenzo salo esichazayo ukuvuselela i-dermal ama-fibroblasts , ngalokho kuqalwa i-cascade elandelayo ekhuthaza ukuhlanganiswa kwakho kokubili i-collagen futhi i-fibronectin.
Nokho, ukuwohloka okusheshayo kwe-enzymatic kuveza isithiyo esibalulekile ekusetshenzisweni kwayo kokwelapha okungokoqobo.
Ukunqoba lokhu, abacwaningi baye bashintsha i-peptide nge ukuhlanganisa ngayo nge amafutha acid iketango. Lokhu kuguqulwa kulondoloza izici zokushaja zangempela kuyilapho kuthuthukisa kakhulu ukusebenzisana ne-intercellular lipids kwe i-stratum corneum.
Ngenxa yalokho, ukuguqulwa kwandisa i-peptide ukuphila okungaphelele futhi ngokuphawulekayo ngcono yayo transdermal ukungena ukusebenza kahle.
Ngokufigqiwe, le peptide ifinyelela ukusebenza kahle kwezimonyo, ukuvikela indawo yayo ekwakhekeni kwe-premium skincare.
Ukulandelana
I-Lys-Thr-Thr-Lys-Ser (KTTKS)
Inombolo ye-CAS
2305730-23-6
I-Molecular Formula
I-C37H71N7O10
Isisindo samangqamuzana
774.01
Ucwaningo Oluhlobene Ne-Myristoyl Pentapeptide-8
1.Ukuhlangana Kwesikhumba Nesikhumba Nokuthuthukisa Isakhiwo Sesikhumba
Ubufakazi bokuhlola bubonisa ukuthi iMyristoyl Pentapeptide-8 ilingisa ukusayinda kwebhayoloji ye i-laminin-5, ngaleyo ndlela iqinisa futhi ilungise isakhiwo kanye nomsebenzi we-dermal-epidermal junction (AMANZI).
Ivuselela ama-dermal fibroblasts ukuthi ahlanganise futhi ahlanganise ukhiye ulwelwesi olungaphansi izingxenye, kuhlanganise collagen I, III, futhi i-elastin.
Umphumela wokugcina uwukuqiniswa kwezakhiwo zangaphakathi zesikhumba, okunciphisa ukujula kanye nenani lemibimbi (ukulahlekelwa kwe-elasticity kuyisici esinomthelela omkhulu), okuholela esikhumbeni esiqinile nesibukeka sinempilo.
Kubuye kube nomthelela omuhle i-keratinocyte umehluko kanye i-keratin i-polymerization.
2.Ukuphromotha Okuqondile Kwe-Dermal Collagen Regeneration
Njengoba kushiwo, i-peptide ibophezela futhi isebenze iphrotheni ehlobene nesamukeli se-LDL (Amaprotheni ahlobene ne-LRP/LDL) endaweni ye-fibroblast, ukuqala imiphumela eshiwo ngenhla.
3.Ukulawulwa Komjikelezo Wokukhula Kwezinwele
I-Myristoyl Pentapeptide-8 yenza kusebenze indlela yokubonisa i-β-catenin/LEF1 ngaphakathi i-papilla yesikhumba amaseli.
Lesi senzo siyavimbela I-BMP4-amasignali okwehla, ngaleyo ndlela yelula ngokuqondile i-anagen (ukukhula) isigaba se-follicle yezinwele.
Ubufakazi bokuhlola obuvela kumodeli yegundane le i-androgenetic alopecia isekela lo mshini; isicelo okuqhubekayo for 21 izinsuku ziholele ekwandeni kokuvumelanisa kwe-eyelash, ishiya, nokuminyana kwezinwele zekhanda.
4.Ukuthuthukiswa Komsebenzi Wokuvimbela Isikhumba kanye Nomsebenzi We-Antioxidant
Isakhiwo esiyingqayizivele seMyristoyl Pentapeptide-8 sinikeza ukuzinza okuthuthukisiwe, nge-myristoyl moiety ngokwayo idala isithiyo esibulalayo.
Yehlisa umkhawulo wokuvula wezinto ezivuvukalayo, ngaleyo ndlela kuthuthukisa ukuqina kwesikhumba ekucindezelekeni kwemvelo.
Isekela ukuhlukaniswa okujwayelekile kwamaseli e-epidermal kanye nomjikelezo wayo we-metabolic.
Ngaphezu kwalokho, ikhuthaza ukuhlanganiswa kwe-lipids eyinhloko (kuhlanganise ama-ceramides) ngaphakathi kwe-stratum corneum, ekugcineni kuqinisa isithiyo esingokomzimba nokudala indawo ekahle yesikhumba.
Umphumela wesikhathi eside uthuthukisa ukuzinza kwesikhumba.
I-COA
I-HPLC
MS
