NA Selank Amidate exhibits improved molecular stability and in vivo pharmacokinetic profile through a double-modification strategy of N-terminal ацетилиране and C-terminal amidation based on the original structure of Селанк.
This results in an increased half-life, enhanced кръвно-мозъчна бариера penetration efficiency, and prolonged bioactivity in both molecular and animal models.
Освен това, NA Selank Amidate exhibits potent имуномодулация and anti-stress activity.
Последователност
ac-thr-lys-pro-arg-pro-gly-pro-nh2
CAS номер
/
Молекулярна формула
C35H60N12O9
Молекулно тегло
792.94
Research Of NA Selank Amidate
1.Retained and Enhanced Efficacy
Efficacy-wise,NA Selank Amidate retains all of the characteristics of Selank, регулиране gamma-aminobutyric acid (GABA) neurotransmission in the brain while also modulating the допаминергичен и серотонинергичен systems to deliver outstanding анксиолитик и antidepressant effects.
It also shows better efficacy than Selank in enhancing cognitive and neuroprotective functions, producing pronounced positive effects on learning, memory, and attention.
2.Anxiolytic and Mood-Stabilizing Effects
In a concentration-dependent and subtype-selective manner, NA Selank Amidate allosterically modulates на GABA-A receptor by potentiating the binding efficacy of GABA to its receptor or enhancing chloride ion channel opening efficiency.
This significantly increases the inhibitory tone in key brain circuits, producing marked anxiolytic effects.
Освен това, the side effects of this anxiolytic action are significantly milder than those of conventional anxiolytic drugs, making NA Selank Amidate a more attractive mood-stabilizing compound.
3.Cognitive Enhancement and Neuroprotection
NA Selank Amidate directly activates BDNF gene transcription by inducing фосфорилиране of the promoter-located КРЕБ transcription factor and acetylation of histone H3, increasing BDNF тРНК levels 3.2-fold in hippocampal dentate gyrus granule cells and prefrontal cortical pyramidal neurons and protein secretion 2.8-fold within 24 часове.
This activates the TrkB receptor signaling pathway downstream, inducing the Ras-MAPK and ПИ3К-Акт cascade to increase дендритен бодил density by 39%, upregulate synaptophysin expression by 45%, and restore LTP amplitude to baseline.
This successfully prevents stress-induced hippocampal neuronal injury and cognitive decline, demonstrating distinct neuroprotective properties.
4.Immunomodulatory and Anti-Stress Effects
NA Selank Amidate is a competitive inhibitor of enkephalin-degrading enzyme, protecting endogenous opioid peptides from хидролиза and thereby elevating their levels, while it inhibits LPS (липополизахарид)-induced expression of pro-inflammatory цитокини включително IL-6 и TNF-α by 40–60% in астроцити.
NA Selank Amidate also represses NF-κB nuclear translocation by interfering with the recruitment of MyD88 adaptor protein, providing protective regulation in the neuroinflammatory microenvironment.
COA
HPLC
MS
