Acetyl Dipeptide-1 Cetyl Ester (INCI npe: Acetyl Dipeptide-1 Cetyl Ester) yog hluavtaws lipopeptides tam sim no tau txais kev saib xyuas ntau nyob rau hauv niaj hnub cosmetic formulations.
Tsim los ntawm bioactive dipeptide Tyr-Arg (tyrosine-arginine) – paub txog cov leeg nqaij fiber ntau relaxing thiab ntau yam soothing zog – nws yog esterified nrog cetyl cawv ua kom cov tawv nqaij affinity thiab nkag mus tom ntej.
Multifaceted muaj peev xwm muaj nyob rau hauv soothing rhiab heev, ntxiv dag zog rau lub hauv paus barrier, thiab txhua hom kev laus cuam tshuam txog kev txhawj xeeb; yog li cov khoom xyaw no tau positioned nws tus kheej li ib qho ze 'qhov tseem ceeb’ molecule nyob rau hauv high-end skincare txoj kev loj hlob.
Ib ntus
Ac-Tyr-Arg-hexadecylester
CAS Nr
196604-48-5
Molecular Formula
C33H57N5O5
Molecular Luj
603.84 g/mol
1.Acetyl Dipeptide-1 cetyl ester yog dab tsi
Acetyl Dipeptide-1 Cetyl Ester yog cov khoom tsim tshwj xeeb peptide rau cov khoom tu tawv nqaij; lub hauv paus tseem ceeb ua haujlwm yog qee yam ntawm daim tawv nqaij soothing, irritation thiab ze rau txhua hom kev txo qis.
Kev txhawb nqa ntawm proopiomelanocortin (POMC) gene qhia yog nws qhov kev tshawb fawb tseem ceeb. Kev ua haujlwm tom qab kev txhais lus ntawm POMC ua rau ntau yam bioactive peptides; melanin synthesis ntsig txog MSHs thiab Adrenocorticotropic cov tshuaj hormones (ACTH) ua ob qho piv txwv, nrog β-endorphin (opoid nquag) kuj tsim.
α-MSH khi rau melanocyte melanocortin receptors, inducing tsawg kawg ib nrab melanin synthesis, tab sis yav dhau los hais txog kev cai ntawm NF-κB kev ua ub no tso cai rau cov nyhuv ncaj qha los tiv thaiv. Txo Calcitonin noob ntsig txog peptide (CGRP) tso tawm yog qhov kawg, tseem ceeb, neuro-soothing link – CGRP nws tus kheej qhib TRPV 1 cov receptors.
Tag nrho cov teebmeem lom neeg saum toj no yog dab tsi ua rau acetyl dipeptide-1 cetyl ester muaj txiaj ntsig rau kev lag luam niaj hnub tshuaj pleev ib ce.. Neuro-soothing, barrier thiab anti-aging teebmeem yog tag nrho interrelatedly tiav los ntawm cov khoom xyaw no mechanisms ntawm kev ua..
2.Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Acetyl Dipeptide-1 cetyl ester
1)Neuro-soothing thiab Anti-inflammatory teebmeem
Hauv ib qho kev tshawb fawb soj ntsuam, 21 Cov neeg ua haujlwm pab dawb tau ntsib qhov txo qis qhov kev nkag siab zoo tom qab siv cov tshuaj nplaum uas muaj 3% acetyl dipeptide-1 cetyl ester. Ib qho kev tshawb nrhiav ob qhov muag tsis pom kev pom 18 ntawm cov neeg ua haujlwm pab dawb no qhia txog kev nplij siab tag nrho hauv ob txhais tes raug cov ntawv xuab zeb puas; tib lub qab zib yog kev cuam tshuam.
Qhov no qhia tau hais tias acetyl dipeptide-1 cetearyl ester alleviates tsawg kawg yog qee qhov tsis xis nyob tshwj xeeb rau cov tawv nqaij hypersensitive., sensory paj hlwb overactivity yog thawj qhov kev txhawj xeeb.
Cov kev tshawb fawb hauv vitro paub meej tias cov khoom xyaw nws tus kheej txo Prostaglandin E2 (PGE 2) zais cia – neurogenic o yog cuam tshuam ncaj qha rau ntawm daim tawv nqaij rhiab heev. Ib txhij, inhibition ntawm qhov xwm txheej nuclear κB (NF- IB) teeb liab pom txoj kev.
NF-κB yog qhov tseem ceeb ntawm kev hloov pauv; ntau pro-inflammatory cytokines (Interleukin-1 beta / IL-1β, Tumor necrosis factor / TNF,Interleukin 6 (IL-6) ntawm lwm tus) raug tswj los ntawm nws, thiab nws suppression zoo curbs inflammatory teb.
2)Txhim kho daim tawv nqaij Barrier
Kev tshawb fawb qhia txog kev txhim kho ntawm ntau yam kab mob cuam tshuam nrog cov noob los ntawm qhov ua haujlwm no, dej aquaporin 3 (AQP3), ua filaggrin (FLG), caspase 14 thiab keratin 10 ua ib qho kev txhim kho tseem ceeb tshaj pom.
3)Anti-Aging Properties
Tshaj li soothing thiab kho yooj yim, ntau lub hom phiaj los tiv thaiv kev laus yog qhov thib peb thiab tej zaum cov txiaj ntsig zoo tshaj plaws.
Yam tsawg kawg hauv vitro, Antioxidant thiab anti-glycation zog tau pom; Dawb radical thiab AGE kev puas tsuaj rau cov hlwb ntawm daim tawv nqaij yog qhov ua rau muaj kev laus.
UV yees duab tshwj xeeb tuaj yeem txo tau los ntawm yav dhau los hais txog autophagy (cellular 'tu') mechanisms, li no pab tswj tag nrho cov tawv nqaij noj qab haus huv thiab cov qauv.
3.Xaus
Acetyl Dipeptide-1 Cetearyl Ester yog ib qho kev xav zoo, niaj hnub kev tu tawv nqaij nquag nrog ntau lub ntsiab lus thiab tawm tswv yim ntawm kev txiav txim los daws qhov sib xws, tseem nyob ze- tas li, niaj hnub kev txhawj xeeb ntawm daim tawv nqaij.
COA
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