Acetyl Tripeptide-1 yog ib qho khoom siv kho teeb liab peptide, synthesized ntawm N-terminal acetylation ("capping" kev hloov kho) ntawm ib txwm tshwm sim tripeptide GHK pom nyob rau hauv ntshav ntshav thiab muaj cov qauv tshuaj zoo ib yam li Acetylated Polypeptide-1. Qhov kev hloov kho cov qauv no hais txog cov teeb meem uas tau hais los saum no ntawm tus thawj GHK, suav nrog instability vim aminoxidases, inactivation nyob rau hauv cosmetic formulations, thiab ib nrab neej luv luv.
Hauv cov ntsiab lus, Acetyl Tripeptide-1 zoo txo cov kab zoo thiab wrinkles, tightens daim tawv nqaij, thiab refines daim tawv nqaij complexion. Nws yog ib qho khoom siv los tiv thaiv kev laus nrog lub meej mom ntawm kev ua haujlwm, siab tshwj xeeb, thiab ua kom pom kev ua tau zoo.
Ib ntus
Ac-Gly-His-Lys-OH
CAS Nr
350595-76-5
Molecular Formula
C16H26N6O5
Molecular Luj
382.42
Acetyl Tripeptide-1 Kev Tshawb Fawb Txog Kev Tshawb Fawb
1.Core Mechanisms thiab Multi-faceted Effects
Cov khoom pov thawj acetylated GHK tau nce hydrophobicity thiab ntev ib nrab-lub neej thaum khaws cia nws rov qab Cu²⁺-chelation khoom. Cov khoom no pab txhawb kev tsim cov tooj liab-peptide complexes hauv txheej dermal, txhim kho kev ua tau zoo yam tsis muaj kev nce ntxiv cytotoxicity.
Nws ua rau dermal fibroblast cov hlwb los tiv thaiv kev laus vim los ntawm chronological lossis ib puag ncig yam. Los ntawm kev khi rau cov cell nto receptors tshwj xeeb, nws activates loj intracellular signaling cascades rau modulate cellular muaj nuj nqi ntawm cov noob caj noob ces.
Nws txhawb nqa cov synthesis thiab secretion ntawm Hom I & III collagen thiab elastin, ua rau denser, daim tawv nqaij tuab. Qhov no, nyob rau hauv lem, txo wrinkles, sagging, thiab hollowing tshwm sim los ntawm collagen poob.
Nws kuj suppresses ntau tshaj matrix metalloproteinase kev ua haujlwm, tsim kom muaj kev tiv thaiv daim tawv nqaij microenvironment uas txo cov degradation ntawm haiv neeg extracellular matrix.
2.Txhawb Collagen thiab Elastin Synthesis
Acetyl Tripeptide-1 nce mus txog txheej dermal ntawm daim tawv nqaij, qhov twg nws ua raws li ib tug ligand rau cov receptors tshwj xeeb ntawm fibroblast cell membrane. Qhov kev khi no ua kom qhib tau mitogen-activated protein kinase (MAPK) thiab phosphoinositide 3-kinase (PIB 3K) qhia txoj kev, txhawb nqa fibroblast proliferation thiab upregulating anabolic metabolism.
Nyob ntawm kev sau ntawv qib, Nws txhim khu kev qhia thiab kev sib txuas ntawm Hom I collagen, Hom III collagen, thiab elastin, li no ua rau lawv cov concentration thiab ceev nyob rau hauv lub dermis. Qhov no ua rau plumper, ntau voluminized daim tawv nqaij. ¹
3.Inhibits Ntau dhau Matrix Metalloproteinase Kev nthuav qhia
Acetyl Tripeptide-1 modulates cellular signaling los txwv cov overproduction ntawm matrix metalloproteinases (MMPs), thaum tseem txo qis tsis tu ncua extracellular matrix degradation los ntawm suppressing lawv synthesis ntawm transcriptional theem.
Khaws cov collagen uas twb muaj lawm los ntawm cov txheej txheem no pab tswj cov tawv nqaij tuab thiab kev ncaj ncees, extends collagen turnover lub sij hawm, thiab yog li no pab txhawb kom ncua kev laus. ²,³
4.Txhim kho Cellular Repair Function
Acetyl Tripeptide-1 qhib txoj hauv kev PI3K/Akt, ib tug tseem ceeb regulator ntawm cellular ciaj sia taus, kev loj hlob, thiab metabolism. Qhov kev txhawb nqa no txhawb kev ua haujlwm fibroblast thiab txhim kho kev kho mob ntawm microtrauma txhua hnub.
Nws kuj tseem tshem tawm cov dawb radicals tsim los ntawm hlau-ion catalysis, li no indirectly tiv thaiv oxidative kev nyuaj siab-induced cellular puas thiab txhawb cov tawv nqaij noj qab haus huv. ⁴
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