Adipotide (FTPP los yog proapototic peptide) yog a peptidomimetic nrog cov amino acid sequence CKGGRAKDC-GG-D (KLAKLAK).
Vim nws txawv structural specification, Nws tuaj yeem paub meej thiab khi rau ob lub receptors ntawm cov hlab ntsha hauv cov ntaub so ntswg adipose: Annexin A2 (ANXA 2) thiab txwv.
Nws txhawb nqa vasoconstriction thiab tom qab apoptosis hauv cov receptor hlwb; cov hlab ntsha lawv tus kheej tsis muab ntshav, oxygen thiab ntau yam khoom noj rau lub hlwb, programmed cell tuag yog qhov kawg tshwm sim.
Qhov no meej mechanism ntawm kev txiav txim yog dab tsi yog siv ncaj qha rau hauv lub tshav pob ntawm yuag poob.
Ib txwm siv glp-1 analogs lossis lwm yam hauv nruab nrab qhov hnyav peptides tsis rov ua dua daim ntawv no ntawm kev txiav txim ncaj qha; adipocytes yog lub hom phiaj, apoptosis yog txhais tau tias kom ua tiav qhov hnyav.
Ib ntus
Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-(dLys-dLeu-dAla-dLys-dLeu-dAla-dLys)2
CAS Nr
859216-15-2
Molecular Formula
C111H206N36O28S2
Molecular Luj
2557.21
Kev tshawb fawb ntawm Adipotide (FTTP)
1.Muaj peev xwm kho tau daim ntawv thov
Nws cov ntawv thov muaj peev xwm suav nrog – hom 2 ntshav qab zib, kev kho mob cancer adjuvant, localized rog txo, non-alcoholic fatty siab kab mob.
2.Kev kho mob hom 2 Mob ntshav qab zib thiab rog rog
Cov kev tshawb fawb ywj pheej tau pom tias tom qab xya hnub ntawm kev kho mob nrog Adipotide cov neeg laus cov nas rog rog tau nthuav tawm cov tshuaj insulin rhiab heev., txhim kho polysaccharide kam rau ua thiab txo cov ntshav triglycerides.
Kev poob phaus tsis yog thawj, los yog tam sim ntawd, cov nyhuv ntawm kev kho mob.
Ib 8 Txoj kev tshawb fawb lub hli tau pom tias Adipotide yog tus neeg sawv cev kho mob zoo heev rau kev tswj kev rog.
Ib txoj hauv kev tsis ncaj tab sis siv tau rau kev kho hom 2 ntshav qab zib kuj tau qhib los ntawm kab kev tshawb fawb no.
3.Adjuvant Therapy rau Cancer
Cov neeg mob qog noj ntshav hnyav hnyav tuaj yeem tau txais txiaj ntsig los ntawm kev txo qis cov ntaub so ntswg adipose (los ntawm vasoconstriction thiab ncaj qha apoptosis) los txhim kho txhua yam tom ntej kws khomob qhov tshwm sim.
4.Kev txo rog hauv zos
Kev txo cov rog hauv zos ua ib txoj hauv kev ntawm Adipotide cov khoom tshwj xeeb.
Adipotide sawv cev rau txoj kev kho tshwj xeeb.
COA
HPLC
MS
