Humanin yog mitochondrial-encoded peptide uas muaj 24 amino acids; thawj zaug pom nyob rau hauv cov ntsiab lus ntawm Alzheimer tus kab mob tshawb fawb.
Hauv cov neeg mob Alzheimer, qhia Humanin nyob rau hauv cov hlwb los yog ntxiv nws li endogenous peptide tiv thaiv cov neurons los ntawm ntau yam Alzheimer's-txog cov ntaub ntawv ntawm kev puas tsuaj. – Cov teebmeem neuroprotective tseem ceeb yog thawj qhov kev soj ntsuam ua.
Humanin qhib txoj hauv kev tseem ceeb ntawm txoj kev ciaj sia, tus JAK2/STAT3/ACT ua piv txwv thawj, zoo inhibiting mitochondrial-dependent apoptotic txoj kev; Aβ, ischemia-hypoxia, thiab ntau hom kev ntxhov siab oxidative yog cov cim tshwj xeeb hais.
Txhim kho cellular antioxidant thiab kom muaj peev xwm tiv thaiv kab mob loj yog lwm cov ntaub ntawv zoo.
Ib ntus
Tau ntsib - Ala - Pro - Arg - Gly - Pheej - Ua - Cys - Leu - Leu - Leu - Leu - Thr - Ua - Glu - Nrog - Asp - Leu - Pro - Val - Lys - Arg - Arg - Ala
CAS Nr
330936-69-1
Molecular Formula
C119H204N34O32S2
Molecular Luj
2687.27
Humanin Related Research
1.Kev kho mob muaj peev xwm thiab kev siv tshuaj kho mob
Cov haujlwm tseem ceeb hauv kev txhawb nqa qabzib metabolism, kev txhim kho yam tsawg kawg ib daim ntawv ntawm insulin rhiab heev, thiab tiv thaiv cov hlab ntsha tau qhia tag nrho.
Yog li ntawd, endogenous tiv thaiv peptide zoo li Humanin tuav lub peev xwm los kho (los yog tsawg kawg yog kev txhim kho) muaj hnub nyoog txog kab mob degenerative; Kev tiv thaiv kev laus thiab kev kho mob Alzheimer tshwj xeeb yog tam sim no tab tom nrhiav raws li kab ntawm kev tshawb fawb no.
2.Metabolic thiab Vascular Protective Functions
Cov haujlwm tseem ceeb hauv kev txhawb nqa cov metabolism hauv qabzib, txhim kho yam tsawg kawg yog qee yam ntawm cov tshuaj insulin rhiab heev, thiab tiv thaiv cov hlab ntsha tau qhia tag nrho.
Yog li ntawd, endogenous tiv thaiv peptide zoo li Humanin tuav lub peev xwm los kho (los yog tsawg kawg yog kev txhim kho) hnub nyoog ntsig txog cov kab mob degenerative; Kev tiv thaiv kev laus thiab kev kho mob Alzheimer tshwj xeeb yog tam sim no tab tom nrhiav raws li kab ntawm kev tshawb fawb no.
3.Cov teebmeem Neuroprotective
Kev tawm tsam ncaj qha ntawm β-amyloid toxicity yog dab tsi txhais Humanin's neuroprotective ua haujlwm – Kev sib sau ua ke thiab kev tso nyiaj tom ntej ntawm Aβ yog qhov tseem ceeb ntawm tus kab mob pib.
Tus receptor nws tus kheej ua rau cov uas tau hais dhau los hauv txoj hauv kev ciaj sia.
Cov teeb liab los ntawm Humanin cuam tshuam txoj hauv kev apoptosis uas tau hais tseg, tua proteins raug suppressed; programmed neuronal tuag yog yam tsawg kawg tiv thaiv ib nrab.
Dhau Aβ, degenerative neurological mob (Parkinson tus kab mob, Huntington tus qhov tseem ceeb) qhia zoo sib xws, yog tsis zoo ib yam, Cov txiaj ntsig neuroprotective los ntawm Humanin.
Kev tiv thaiv kab mob plawv sawv cev rau ib qho tseem ceeb ntawm Humanin tus nqi kho mob.
Humanin txoj kev loj hlob raws li tus neeg sawv cev kho mob sawv cev rau kev nce qib tseem ceeb hauv kev tshawb fawb kho mob.
4.Antioxidant thiab Anti-Apoptotic teebmeem
Humanin lub hauv paus, Lub luag haujlwm tseem ceeb yog inhibiting ib txwm cell apoptosis tshwm sim los ntawm kev ntxhov siab ntau dhau.
Ntau dhau oxidative kev nyuaj siab thiab tom qab no daim ntawv ntawm apoptosis yog ib qho tseem ceeb ua rau muaj ntau yam kab mob thiab tag nrho cov muaj hnub nyoog..
Humanin txhim kho cov tshuaj tiv thaiv kev ntxhov siab hauv cov ntaub so ntswg; tiv thaiv kev tso tawm ntawm mitochondrial cytochrome C yog ib feem tseem ceeb ntawm txoj kev no. Qhov no muaj zog physiological mechanism suppresses qhov pib ntawm intrinsic apoptosis txoj kev, oxidative kev puas tsuaj yog qhov kev txhawj xeeb tseem ceeb.
Qhov tseem ceeb, Humanin's cell-stabilizing cuam tshuam txuas ntxiv tshaj li cov ntaub so ntswg tshwj xeeb – Kev paub ntau yam kev tiv thaiv tiv thaiv ob qho tib si oxidative kev nyuaj siab thiab txhua hom ntawm apoptosis, yog qhov Humanin muab; Kev siv dav ntawm qhov kev tiv thaiv no raug pom.
5.Kev cai ntawm lub cev
Humanin plays lub luag haujlwm tseem ceeb hauv kev tswj cov txheej txheem metabolic homeostasis, cellular stability yog ib qho ntawm nws cov txiaj ntsig pom tau ncaj qha. Glucose metabolism yog ib qho piv txwv tseem ceeb.
Kev sim tau pom qhov ntsuas qis dua ntawm humanin hauv hom 2 cov neeg mob ntshav qab zib.
Supplementing humanin zoo txhim kho qabzib kam rau ua; kev tiv thaiv ntawm pancreatic β-hlwb (apoptosis dawb) thiab cov hauv qab no, Kev tsim cov tshuaj insulin zoo heev uas muaj kev sib txuas zoo.
Ib txoj hauv kev kho tshiab rau ntshav qab zib thiab cuam tshuam metabolic syndromes, humanin qhia cov lus qhia cog lus rau tshuaj.
COA
HPLC
MS
