Humanin ndeye mitochondrial-encoded peptide inosanganisira 24 amino acids; yakatanga kuwanikwa mukati memamiriro ekutsvaga kwechirwere cheAlzheimer.
Mune varwere veAlzheimer, kuratidza Humanin mukati memasero kana kuiwedzera se peptide inogadzika inodzivirira idzi neuroni kubva kune akasiyana siyana ane hukama neAlzheimer's – yakakosha neuroprotective mhedzisiro iri yekutanga kucherechedzwa kwakaitwa.
Humanin inomutsa nzira dzakakosha dzekupona kwesero, the JAK2/STAT3/ACT kuva mienzaniso mikuru, zvinobudirira kuvharidzira mitochondrial-inotsamira apoptotic nzira; Aβ, ischemia-hypoxia, uye marudzi akawanda e oxidative stress ari iwo chaiwo anokonzera anotaurwa.
Kuvandudza cellular antioxidant uye kusvika pamwero mukuru anti-kuzvimba masimba ndeimwe yakanyatso kunyorwa mhedzisiro.
Kutevedzana
Met - Ala - Pro - Arg - Gly - Phe - Kuva - Cys - Leu - Leu - Leu - Leu - Thr - Kuva - Glu - With - Asp - Leu - Pro - Val - Lys - Arg - Arg - Ala
Nhamba yeCAS
330936-69-1
Molecular Formula
C119H204N34O32S2
Molecular Weight
2687.27
Humanin Related Research
1.Therapeutic Potential uye Clinical Applications
Mabasa akakosha mukusimudzira glucose metabolism, kuvandudza kanenge imwe mhando ye insulin sensitivity, uye kudzivirira tsinga dzeropa zvose zvakaratidzwa.
Naizvozvo endo native inodzivirira peptide senge Humanin inobata mukana wakakura wekurapa (kana kuti kuvandudza) zvinoenderana nezera degenerative zvirwere; anti-kuchembera uye mamwe chaiwo kurapa kweAlzheimer parizvino kuri kuteverwa zvichibva pane iyi mutsara wekutsvaga.
2.Metabolic uye Vascular Protective Mabasa
Mabasa akakosha mukusimudzira glucose metabolism, kuvandudza kanenge imwe nzira ye insulin senitivity, uye kudzivirira tsinga dzeropa zvose zvakaratidzwa.
Naizvozvo endo native inodzivirira peptide senge Humanin inobata mukana wakakura wekurapa (kana kuti kuvandudza) zera rinosangana nezvirwere zvinopera; anti-kuchembera uye mamwe chaiwo kurapa kweAlzheimer parizvino kuri kuteverwa zvichibva pane iyi mutsara wekutsvaga.
3.Neuroprotective Migumisiro
Iko kupikisa kwakananga kwe-β-amyloid toxicity ndiyo inotsanangura basa reHumanin's neuroprotective. – kuunganidza uye kunotevera kuiswa kweAβ zvinhu zvakakosha mukutanga kwechirwere.
Iyo receptor pachayo inomutsa idzo dzakambotaurwa intracellular nzira dzekupona.
Zviratidzo kubva kuHumanin zvinodzivisa nzira dzambotaurwa dzeapoptosis, mapuroteni ekuuraya ari kudzvinyirirwa; kufa neuronal kwakarongwa kunodzivirirwa zvishoma.
Kupfuura Aβ, degenerative neurological disorders (Parkinson's, Huntington's zvikuru) ratidza zvakafanana, kana zvisina kufanana, neuroprotective inobatsira kubva kuHumanin.
Kudzivirirwa kwemoyo inomiririra chikamu chakakosha cheHumanin's therapeutic value.
Kubudirira kweHumanin semumiririri wekurapa kunomiririra kufambira mberi kwakakosha musainzi yekurapa.
4.Antioxidant uye Anti-Apoptotic Migumisiro
Hunhu musimboti, basa rakakosha kuvharidzira zvakajairika sero apoptosis inokonzereswa nekunyanya kushushikana.
Yakawandisa oxidative kusagadzikana uye nekudaro iyi fomu yeapoptosis ndeimwe yezvikonzero zvakakosha zvezvirwere zvakasiyana uye ese ane hukama nezera..
Humanin inowedzera antioxidant kushushikana basa mukati mematishu maseru; kupikisa kusunungurwa kwemitochondrial cytochrome C kuva chikamu chinokosha chemuitiro uyu. Iyi yakasimba physiological mechanism inodzvinyirira kutangwa kwemukati apoptosis nzira, oxidative kukuvara ndiyo inonyanya kunetseka.
Noently, Humanin's cell-stabilizing mhedzisiro inowedzera kupfuura chaiwo maseru ematishu – yakazara-yakawanda-yakatarisana dziviriro kubva kune yakawandisa oxidative kusagadzikana uye ese marudzi ayo eapoptosis, ndizvo izvo Humanin inopa; kushanda kwakawanda kwekudzivirira uku kunoonekwa.
5.Physiological Regulation
Humanin inoita basa rakakosha mukudzora systemic metabolic homeostasis, kugadzikana kwe cellular kuve imwe yemhedzisiro yayo inotariswa zvakanyanya. Glucose metabolism ndiyo muenzaniso wakanaka.
Ongororo dzakaratidza mazinga akaderera akayerwa ehumanin mumhando 2 vane chirwere cheshuga.
Kuwedzera humanin zvinobudirira glucose kushivirira; kuchengetedza kwe pancreatic β-masero (apoptosis mahara) uye zvinotevera, inoshanda insulin secretion iyo yakabatana zvakanyanya.
A novel therapeutic approach yechirwere cheshuga uye yakabatana metabolic syndromes, humanin inopa nzira dzinovimbisa dzemushonga.
COA
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