Glycyl-L-Histidyl-L-Lysine, okanye GHK, yi tripeptide eyenziwe iglycine, histidine, kwaye ilysine. Le peptide yenzeka ngokwemvelo emzimbeni womntu; iplasma yegazi, amathe, kwaye umchamo uqulethe yonke into, kunye namanqanaba ehla njengenxalenye yenkqubo yokuguga. I-GHK ibophelela kwiiyoni zethusi (Cu²⁺) ukwenza i-GHK-Cu eyinkimbinkimbi. I-complex ngokwayo ivula iindlela ezahlukeneyo zokubonisa iiselula; Uluhlu olubanzi lweziphumo zebhayoloji ziphuma kolu lwenziwa.
Ulandelelwano
Gly-His-Lys
Inombolo yeCAS
49557-75-7
Ifomula yeemolekyuli
I-C14H24N6O4
Ubunzima beMolekyuli
340.38
Uphando lweGHK/Tripeptide-1
1.Imisebenzi yebhayoloji eNxulutywayo
I-GHK isebenza kuzo zombini umqondiso kunye nomthamo we-peptide yomthwali. Njengomqondiso wepeptide, iiseli zesikhumba zikhuthazwa ukuba zivelise izixa ezandisiweyo ze elastin, iiproteoglycans, glycosaminoglycans, kwaye ekugqibeleni i-collagen. Umba womthwali unikezela ngezinto ezibalulekileyo umkhondo element ubhedu ngqo kwezi seli.
Ezi ndima zimbini zinoxanduva loluhlu olubanzi lwemisebenzi yebhayoloji yemiboniso yeGHK – ukulungiswa kwezicubu kungumzekelo obalaseleyo, ihamba ne anti-ukudumba kwaye iphawuleka antioxidant iipropati, imiphumo enokubakho ye-anticancer, kwaye eyahlukileyo Ukulawulwa kwembonakalo yemfuza.
2.Ulusu Ukuzalwa ngokutsha Kwaye Lungisa
Ukuxhasa ukuvuselelwa kwesikhumba ngenye yeempembelelo ezibhalwe ngokucokisekileyo zeGHK. Izifundo ziqinisekisa i-collagen (kunye nokuba ngqo glycosaminoglycans/ukuhombisa) ukudibanisa kuyavuselelwa. Ukulawulwa kwesitshixo metalloproteinases (Ukuqhekeka kwe i-matrix engaphandle ngumsebenzi wabo ophambili) kunye ne-anti-proteases nayo ibonakalisiwe.
Isenzo esiphindwe kabini esikhankanywe ngaphambili sinika i-GHK impembelelo ebanzi yokulawula kuyo yonke imiba yokuqhekeka kweprotheyini yesikhumba.; ukuthintela zombini ukuqokelela okugqithisileyo kweeprotheni ezonakalisiweyo kunye nokuthotywa ngokupheleleyo.
3.I-Antioxidant / Ukuchasana nokudumba Iipropati
I-antioxidant enamandla kunye ne-wide-spectrum anti-inflammatory capabilities i-GHK. Inobungozi mahala radicals ukusuka i-lipid peroxidation zingathathi hlangothi, iikeratinocytes ngokukodwa ukukhuselwa kumonakalo owenziwe yi-UV. Ukuvala ngokupheleleyo ubhedu oluxhomekeke kwi-oxidation ye LDL(I-Low-Density Lipoprotein) ngomnye umzekelo ocacileyo wale ndlela yokukhusela.
4.Gene Expression Regulation
I-GHK ixhasa ukulungiswa kwezicubu ezidibeneyo kunye nokulungiswa ngokutsha ngokusebenzisa i-gene expression. Ukuguqulwa kotyikityo lwemfuzo ye COPD(Isifo semiphunga esingapheliyo) ngumgca obalulekileyo wophando; 127 izakhi zofuzo zibandakanyeka kwisifo kwaye i-GHK ibonakaliswe ukuba ibabuyisele kwimeko ephilileyo.
5.Izifundo zeMolekyuli zokuSebenza
Uphando olukhulayo lubonisa ukuba i-GHK inokusetha kwakhona i-gene ephosakeleyo kunye neprotheyini yokubonakalisa, kwaye IUPS(Inkqubo ye-Ubiquitin-Proteasome) umsebenzi, ukuya kwimeko esempilweni.
Ukuchasana nokuguga kunye nokukhuthaza impilo, ngenxa yazo zonke ezi zinto zingasentla, yinjongo enqweneleka kakhulu yosetyenziso lweGHK.
Amandla ayo onyango ke ngoko aninzi.
I-COA
HPLC
NKSK
