IHumanin yipeptide efakwe kwimitochondrial equka 24 iiamino acids; ekuqaleni ifunyenwe ngaphakathi kwimeko yophando lwesifo se-Alzheimer.
Kwizigulane ze-Alzheimer, Ukuvakalisa i-Humanin ngaphakathi kweeseli okanye ukuyongeza njenge-peptide engapheliyo ikhusela ezi neurons kwiindlela ezahlukeneyo zomonakalo ezinxulumene ne-Alzheimer. – Iziphumo ezibalulekileyo ze-neuroprotective ziluqwalaselo oluphambili olwenziweyo.
I-Humanin ivula iindlela eziphambili zokusinda kweeseli, i JAK2/STAT3/ACT ukuba yimizekelo ephambili, ngokufanelekileyo ukuthintela iindlela ze-aptotic ezixhomekeke kwi-mitochondrial; Aβ, ischemia-hypoxia, kunye neentlobo ezininzi zoxinzelelo lwe-oxidative ukuba zezona zibangela zikhankanyiweyo.
Ukuphucula i-antioxidant yeselula kunye nobukhulu bezakhono zokuchasa ukudumba sesinye isiphumo esibhalwe kakuhle.
Ulandelelwano
Wadibana - Ewe - UPro - Arg - Gly - Phe - Ukuba - Cys - Leu - Leu - Leu - Leu - Thr - Ukuba - Glu - Nge - Asp - Leu - UPro - Val - Lys - Arg - Arg - Ewe
Inombolo yeCAS
330936-69-1
Ifomula yeemolekyuli
I-C119H204N34O32S2
Ubunzima beMolekyuli
2687.27
UPhando oluNxulumene noBuntu
1.Unyango olunokubakho kunye nezicelo zeklinikhi
Imisebenzi ebalulekileyo ekukhuthazeni i-glucose metabolism, ukuphucula ubuncinci uhlobo oluthile lwe uvakalelo lwe-insulin, kunye nokukhusela imithambo yegazi zonke zibonisiwe.
Ke ngoko i-peptide ekhuselayo engapheliyo njengeHumanin ibambe amandla amakhulu okunyanga (okanye ubuncinane ukuphucula) ezinxulumene nobudala izifo eziwohlokayo; Ukuchasana nokuguga kunye nonyango oluthile lwe-Alzheimer's okwangoku lulandelwa ngokusekelwe kulo mgca wophando.
2.Imisebenzi yoKhuseleko lweMetabolic kunye neVascular
Imisebenzi ebalulekileyo ekukhuthazeni i-glucose metabolism, ukuphucula ubuncinci uhlobo oluthile lwe-insulin sensitivity, kunye nokukhusela imithambo yegazi zonke zibonisiwe.
Ke ngoko i-peptide ekhuselayo engapheliyo njengeHumanin ibambe amandla amakhulu okunyanga (okanye ubuncinane ukuphucula) izifo ezinxulumene nobudala; Ukuchasana nokuguga kunye nonyango oluthile lwe-Alzheimer's okwangoku lulandelwa ngokusekelwe kulo mgca wophando.
3.Iimpembelelo zeNeuroprotective
Ukuchasana ngokuthe ngqo kwe-β-amyloid toxicity yinto echaza umsebenzi we-neuroprotective ye-Humanin – ukuhlanganiswa kunye nokubekwa okulandelayo kwe-Aβ zizinto eziphambili ekuqaliseni kwesi sifo.
I-receptor ngokwayo isebenze ezo ndlela zikhankanywe ngaphambili ze-intracellular zokusinda.
Iimpawu ezivela kwi-Humanin zithintela iindlela ze-apoptosis ezikhankanywe ngasentla, iiproteni zokubulawa zicinezelwe; Ukufa kwe-neuronal okucwangcisiweyo kuthintelwe kancinane.
Ngaphaya kwe-Aβ, ukuphazamiseka kwe-neurological degenerative (Parkinson's, eHuntington ngokukodwa) bonisa okufanayo, ukuba ayifani, izibonelelo ze-neuroprotective ezivela kwi-Humanin.
Ukukhuselwa kwentliziyo kubonisa inkalo ebalulekileyo yexabiso le-Humanin lonyango.
Uphuhliso lwe-Humanin njenge-arhente yonyango lubonisa ukuqhubela phambili okubalulekileyo kwisayensi yezonyango.
4.I-Antioxidant kunye ne-Anti-Apoptotic Effects
Undoqo wobuntu, Umsebenzi osisiseko kukuthintela i-apoptosis yeeseli eqhelekileyo ebangelwa luxinzelelo olugqithisileyo.
Uxinzelelo olugqithisileyo lwe-oxidative kwaye emva koko olu hlobo lwe-apoptosis luphakathi kwezizathu ezisisiseko zezifo ezahlukeneyo kunye nazo zonke iimeko ezinxulumene nobudala..
I-Humanin iphucula umsebenzi woxinzelelo lwe-antioxidant ngaphakathi kweeseli zezicubu; ukumelana nokukhululwa kwe-mitochondrial icytochrome C ukuba yinxalenye ephambili yale nkqubo. Le ndlela inamandla ye-physiological icinezela ukuqaliswa kweendlela ze-apoptosis zangaphakathi, umonakalo oxidative yeyona nto ixhalabisayo.
Ngokucacileyo, Iziphumo zokuzinzisa iiseli ze-Humanin zidlulela ngaphaya kweeseli zethishu ezithile – Ukhuseleko olubanzi olunamacala amaninzi ngokuchasene noxinzelelo olugqithisileyo lwe-oxidative kunye nazo zonke iintlobo zazo ze-apoptosis, yinto eyenziwa nguHumanin; Ukusetyenziswa okubanzi kolu khuseleko kuyabonwa.
5.Physiological Regulation
I-Humanin idlala indima ebalulekileyo ekulawuleni i-homeostasis ye-systemic metabolic, uzinzo lweselula sesinye seziphumo zayo eziqaphelekayo ngokuthe ngqo. I-glucose metabolism ngumzekelo obalaseleyo.
Iimvavanyo zibonise amanqanaba aphantsi alinganisiweyo e-humanin ngokohlobo 2 izigulane zeswekile.
Ukongezwa kwe-humanin kuphucula ngokufanelekileyo ukunyamezela kweglucose; ukhuseleko lwe iiseli zepancreatic (i-apoptosis yasimahla) kunye nokulandelayo, imfihlo esebenzayo ye-insulin edityaniswe ngokusondeleyo.
Indlela entsha yonyango yesifo seswekile kunye nezinto ezinxulumene nazo iimpawu ze-metabolic syndromes, I-humanin icebisa imiyalelo ethembisayo yeyeza.
I-COA
HPLC
NKSK
