I-Acetyl Dipeptide-1 cetyl ester

1.Iyini i-Acetyl Dipeptide-1 cetyl ester

I-Acetyl Dipeptide-1 Cetyl Ester iyi-peptide yokwenziwa eklanyelwe ngokukhethekile imikhiqizo yokunakekelwa kwesikhumba.; umsebenzi oyinhloko oyinhloko wuhlobo oluthile lokupholisa isikhumba, ukucasuka futhi eduze kwazo zonke izinhlobo zokunciphisa ukuvuvukala.

Ukukhuthazwa kwe proopiomelanocortin (I-POMC) i-gene expression yisenzo sayo esicwaningiwe esibalulekile. Ukucutshungulwa kwangemva kokuhumusha kwe-POMC kuholela kuma-peptide amaningi e-bioactive; ama-MSH ahlobene ne-melanin synthesis kanye i-hormone ye-adrenocorticotropic (ACTH) njengezibonelo ezimbili eziyinhloko, nge β-endorphin (i-opoid esebenzayo) futhi kukhiqizwa.

I-α-MSH ibophezela ku-melanocyte I-melanocortin receptors, ukunxenxa okungenani ingxenye ye-melanin synthesis, kodwa ukulawulwa okushiwo ngaphambili komsebenzi we-NF-κB kuvumela umphumela oqondile wokulwa nokuvuvukala. Ukunciphisa I-peptide ehlobene ne-Calcitonin (I-CGRP) ukukhululwa kungokugcina, nokho kubalulekile, isixhumanisi se-neuro-soothing – I-CGRP ngokwayo iyasebenza I-TRPV1 ama-receptors.

Yonke le miphumela engenhla yezinto eziphilayo yiyo eyenza i-acetyl dipeptide-1 cetyl ester ibaluleke kangaka embonini yesimanje yezimonyo.. I-Neuro-soothing, Isithiyo kanye nemiphumela yokulwa nokuguga konke kufinyelelwa ngokuhlobene ngokusebenzisa izindlela zokusebenza zalesi sithako..

2.Imiphumela Yocwaningo Ku-Acetyl Dipeptide-1 cetyl ester

1)I-Neuro-soothing kanye ne-Anti-inflammatory Effects

Ocwaningweni olulodwa lomtholampilo, 21 amavolontiya abona izinga lokushisa elinciphe kakhulu ngemva kokufaka ukhilimu oqukethe 3% i-acetyl dipeptide-1 cetyl ester. Isaha elihlukile le-double blind 18 kulawa mavolontiya abika amazinga aphezulu wokunethezeka jikelele ezandleni ezithinteka ekuhutsheni kwe-sandpaper; ukhilimu ofanayo kwaba ukungenelela.

Lokhu kuphakamisa ukuthi i-acetyl dipeptide-1 cetearyl ester inciphisa okungenani ukungaphatheki kahle okuthile esikhumbeni esizwela kakhulu., isimiso sezinzwa sezinzwa ukusebenza ngokweqile kuwukukhathazeka okuyinhloko.

Izifundo ze-in vitro ziqinisekisa ukuthi isithako ngokwaso sinciphisa I-prostaglandin E2 (PGE2) imfihlo – ukuvuvukala kwe-neurogenic kufakwe ngqo esikhumbeni esibucayi. Kanyekanye, ukuvinjwa kwe-nuclear factor κB (I-NF-kB) ukusayina indlela iyabonwa.

I-NF-κB iyisici esibalulekile sokuloba; ama-cytokines amaningi ane-pro-inflammatory (I-Interleukin-1 beta /IL-1β, I-Tumor necrosis factor/TNF,I-Interleukin 6 (I-IL-6) phakathi kwabanye) kulawulwa ngayo, futhi ukucindezelwa kwayo kunqanda ngempumelelo izimpendulo zokuvuvukala.

2)Ukuqinisa Isithiyo Sesikhumba

Ucwaningo lubonisa ukwenyuswa kwezakhi zofuzo ezihlobene nesithiyo ngalokhu okusebenzayo, i-aquaporin 3 (I-AQP3), i-filaggrin (I-FLG), i-caspase 14 kanye ne-keratin 10 ukuba phakathi kwentuthuko ebonakala kakhudlwana.

3)Izakhiwo Zokuguga

Ngaphandle kokulungiswa okupholile nokulula, anti-ukuguga okuhloswe ngakho okuningi kuwumphumela wesithathu futhi mhlawumbe ofiseleka kakhulu.

I-in vitro okungenani, Izakhiwo ze-antioxidant kanye ne-anti-glycation ziye zaboniswa; ama-radical amahhala kanye nokulimala kwe-AGE kumaseli esikhumba kunomthelela njalo ekugugeni.

Ukuthwebula izithombe kwe-UV ngokuqondile kungancishiswa yi-autophagy eshiwo ngaphambilini (ukuhlanza amaselula) izindlela, ngaleyo ndlela kusiza ukugcina impilo yesikhumba jikelele kanye nokwakheka.

3.Isiphetho

I-Acetyl Dipeptide-1 Cetearyl Ester icatshangwe kahle, I-skincare yesimanje isebenza ngezindlela eziningi ezichaziwe nezisafufusa zokuxazulula okuvamile, nokho eduze-njalo, izinkathazo zesikhumba zanamuhla.