I-Acetyl Hexapeptide-38 (igama lohwebo Adifyline®) iyi-peptide yokwenziwa esetshenziswa kakhulu ngaphakathi kwemithi yobuhle nokulungisa isikhumba. Ukuqondisa i-dermal fibroblasts, ikhuthaza ukuhlanganiswa kwe-collagen kanye nokuqina kwamafutha angaphansi kwesikhumba; ukuthuthukiswa kwesakhiwo sesikhumba kanye nezinhlobo ezihlukahlukene zokulungisa izicubu kuyimiphumela eqondile yalo msebenzi.
Ukulandelana
I-Ac-Ser-Val-Val-Val-Arg-Thr-NH₂
Inombolo ye-CAS
1400634-44-7
I-Molecular Formula
I-C30H56N10O9
Isisindo samangqamuzana
700.83 g/mol
Iyini i-Acetyl Hexapeptide-38
I-Acetyl Hexapeptide-38 ngokwayo iyi-peptide eguquliwe e-acetylated – ama-amino acid ayisithupha ubude. Idizayini yamangqamuzana e-peptide ilingisa ama-peptide emvelo e-bioactive, ngezinzuzo ezengeziwe zokukhula kokuqina kanye nokunwebeka kwesikhumba.
Ekuqaleni yasungulwa izinkampani zezimonyo kanye ne-biomaterial, izinkinga zokuguga kwesikhumba (imibimbi, ukuxega, ukukhubazeka kwezicubu ezithambile okuyizibonelo eziyinhloko) yilokho le peptide eyadalelwa ukubhekana nayo. Ucwaningo lubonise ukungena okuphumelelayo kudlule umgoqo wesikhumba wokuqala; ukusebenza ngaphakathi kwe-dermis, Ukulawulwa kwe-extracellular matrix metabolism kuyinqubo eyinhloko eholela kuzo zonke izinhlobo zokulungiswa kabusha kwesakhiwo kanye nokulungiswa okulandelayo..
Umsebenzi oyinhloko we-Acetyl Hexapeptide-38 ngakho-ke ungumgqugquzeli wokulungisa izicubu ezibanzi. Isikhumba fibroblasts kanye ama-adipocytes yizona okuhloswe ngazo, ngezinqubo ezithile zebhayoloji ezilawulwayo yonke indawo.
Njengamanje indlela okuxoxwa ngayo kabanzi ihlanganisa ukugqugquzela ukuvezwa kwe I-Peroxisome Proliferator Yasebenza Isamukeli I-Gamma Coactivator 1-alpha (I-PGC-1a). I-PGC-1α iyisilawuli esiyinhloko se i-mitochondrial biogenesis kanye nakho konke okuhlobene ne-energy metabolism. Ukulawulwa okuphezulu kwaleli phrotheni kuholela (okungenani kancane) ukwanda kwe-lipid synthesis kanye nokuqoqwa kwama-adipocyte – ukwanda kwevolumu yezicubu ze-adipose kuwumphumela wokugcina. Ukugcwala kwesikhumba kanye nemibimbi encishisiwe ye-atrophic kokubili kuyizinkomba zomtholampilo ezinhle zalo mphumela.
Lesi sakhiwo sinika amandla uhlobo olungokwemvelo lokwandisa umthamo wamafutha (izihlathi zobuso, amabele njll.) okumele kuzuzwe; 'i-peptide yokuthuthukisa ibele’ incazelo evamile okungenani okunye ukusetshenziswa kwayo.
I-Acetyl Hexapeptide-38 ithuthukisa ukuminyana nokuzinza kwe i-collagen fibers ku-dermis, njengoba kushiwo ngaphambili, ngayo yonke le miphumela ehlanganisiwe engenhla.
Ngokusekelwe kuzo zonke izindlela ezichaziwe, I-Acetyl Hexapeptide-38 inekusasa langempela nelithembisayo kwezokwelapha zobuhle. Ukulungiswa kwezindlela ezimbili kanye nokujiya kwezicubu ezithambile kuyindawo yokugcina efiselekayo.
I-Acetyl Hexapeptide-38 ingumgqugquzeli othembisayo wokulungisa isikhumba.
I-COA
I-HPLC
MS
(2) DELGADO GONZÁLEZ, R.; I-SOLEY ASTALS, A.; I-COURTOIS, A.; UTHOLAS, B. I-EXOPOLYSACCARIDE YOKWELAPHA KANYE/NOMA UKUNAKEKELA ISIKHUMBA, AMAKHUMBULU KANYE/NOMA IZINZIPHO. EP2827837B8.
(3) Wu, Y.; Yebo, H.; ULyu, Y. Inqubekelaphambili yocwaningo lwama-collagen peptide emvelo kanye nempumelelo yayo yokunakekelwa kwesikhumba. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2022, 39 (6), 1254-1262. I-DOI: 10.7507/1001-5515.202207009 Kusuka ku-NLM.
