I-Oligopeptide-41 iyi-peptide esebenza kakhulu esetshenziswa ngaphakathi kwezimonyo nemikhiqizo ehlukahlukene yokunakekelwa kwezinwele..
Kususelwa ekulingiseni nasekusetshenzisweni kahle kwe- β-hairpin isakhiwo esiqondene ne- I-keratinocyte ukukhula factor(I-KGF), ihlose i-follicle yezinwele ama-stem cell.
Ukugcinwa kokuhambisana okuphezulu maqondana ne- I-FGFR2-IIIb i-subunit iyagcinwa, ngokuncishiswa okubalulekile kokubopha okuphambene ku I-FGFR1; ukunciphisa imitotic okukhulunywe ngayo ngenhla “i-follicle engeyona yezinwele” imiphumela emibi kanye nokwelula isigamu sempilo.
Okuqhamuka uma udla imishanguzo (ukulunywa, umbala wejwabu leso ngokuba izibonelo eziyinhloko) zigwenywa kakhulu.
Ukulandelana
Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe
Inombolo ye-CAS
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I-Molecular Formula
I-C63H90N18O19S
Isisindo samangqamuzana
1435.58
Ucwaningo Oluhlobene Ne-Oligopeptide-41
1.Izindlela Zokwenza kanye Nempumelelo
Ukuhlola kubonise le peptide eyenza izindlela ezimbili zisebenze – β-catenin/Wnt futhi KANJANI-STAT5 – kumaseli we-ORSc stem; ukulawulwa kwenkulumo yamaprotheni ehlobene kanye nezici eziphikisana ne-apoptotic ziyalandela.
Ukwandisa isigaba sokukhula kwe-follicle yezinwele kuwumphumela oqondile, Ukuhlukaniswa kwe-melanocyte stem cell kuyakhuthazwa, ukukhula kwezinwele ezimpunga kuncishiswe kakhulu.
I-microcirculation yendawo iyathuthukiswa, umthamo we-antioxidant ama-melanocyte ukhulisiwe futhi amazinga e-hydrogen peroxide ehlisiwe.
2.Ukusebenza ngempumelelo kathathu kufinyelelwa
ukuvimbela ukulahlekelwa izinwele, ukukhuthazwa kokukhula kwezinwele okusebenzayo, ukubambezeleka noma ukuyeka ngokuphelele ukumpunga.
3.Ukunweba Isigaba se-Anagen
Ukubophezela kuma-FGFR2-IIIb ama-receptors endaweni yeseli ye-follicular kubangela ukuncipha kwe-receptor futhi okulandelayo i-phosphorylation.
Indlela ye-Wnt/β-catenin iyasebenza, ama-keratinocyte precursors ahlala esesimweni se-stem, ukuhlukaniswa kwetheminali kubambezelekile.
Ex vivo amamodeli amasiko ezinwele zezinwele zomuntu abonise ukwanda okucacile nokulinganisekayo kukho kokubili ubude nobuningi besigaba se-anagen..
4.Ukwenza kusebenze amaseli we-melanocyte futhi kuvimbele izinwele ezimpunga
Isiqephu3 futhi I-MITF-M ukubonakaliswa kofuzo kulawulwa.
Ukwehlukana kuma-melanocyte avuthiwe kuyakhuthazwa.
Izivivinyo zokwelashwa zisekela zonke izinzuzo ezishiwo ngaphambili ze-Oligopeptide-41.
Imisebenzi eyengeziwe ye-peptide iyacwaningwa, kodwa zonke zixhumene nezindlela ezichazwe ngaphambilini.
Imiphumela emisha ye-microcirculatory kanye ne-anti-inflammatory ithakazelisa ngokukhethekile ikusasa lezinwele nempilo yesikhumba.
I-COA
I-HPLC
MS
