ʻO Cartalax kahi peptide synthetic kaulahao pōkole me ke kaʻina amino acid Ala-Glu-Asp.. Lawe ʻia mai kahi ʻāpana protein maoli i loko o ka cartilage olakino, he mole synthetic i hoʻolālā maikaʻi ʻia.
ʻO ke kaʻina kikoʻī o nā ʻakika amino e like me nā mea o endogenous nā molekala hōʻailona; ka hoʻopaʻa ʻana i kekahi mau mea lawe kelepona, Hoʻomaka ʻia kahi cascade hope o nā pane kelepona.
Hāʻawi ka hoʻolālā synthetic kūpono iā Cartalax i ka hana olaola kiʻekiʻe, kikoʻī, haʻahaʻa immunogenicity, a maikaʻi ka transdermal a i ʻole ka lawe waha.
Ke hoʻomau nei ka noiʻi ʻana i nā kikoʻī i kāna mau pahuhopu nui, hiki ke pale a me ka reparative nui-level.
ʻO ka hoʻopau maikaʻi ʻana i ka mumū kekahi o ia hopena – hoʻohaʻahaʻa iho o cytokine pro-inflammatory hoʻokomo ʻia Matrix metalloproteinases (MMPs) a ADAMTS ʻo ia nā mea hana mua; ka hoʻoneʻe pololei a me ka hoʻohaʻahaʻa ʻana o ke ʻano II collagen a me nā ʻano like ʻole proteoglycans hoemiia, cartilage articular mālama ʻia ka paʻa o ka hale.
Hoʻonui i ka hiki ke hoʻoponopono hou i ka matrix extracellular ʻo ia kekahi laina o ka hana i manaʻo ʻia e nā haʻawina hou; chondrocyte Hoʻoponopono ʻia nā māka kikoʻī a hāpai ʻia kā lākou synthesis.
Hiki ke hoʻoponopono ʻia nā pōʻino liʻiliʻi ma o kēia mau ala, olakino homeostasis mālama ʻia.
Anti-inflammatory, ʻO nā waiwai immunomodulatory a me nā mea kūʻē i ka wā kahiko he ʻāpana āpau o ka ʻaoʻao o Cartalax; Ke ʻimi nei nā hoʻokolohua lapaʻau i nā mea a pau i luna.
ʻO ka Synthesis a me ka hoʻohana ʻana o Cartalax kahi kuhikuhi hoʻohiki o ka bioactive peptide therapy.
Kaʻina
Ala-Glu-Asp
Helu CAS
/
ʻĀpana Molekala
C12H19N3O8
Kaumaha Molecular
333.297
Noi'i o Cartalax Peptide
1.Kāohi ʻana i ka Cartilage Ka hoʻopāpā
E like me ka olelo, ʻo ka pale ʻana i ka hoʻohaʻahaʻa nui ʻana ma ke kumu o nā noiʻi āpau ma Cartalax.
Kūʻē mea pro-inflammatory pono ke hookiia ka hoailona, a me nā enzymes kuleana no ka hoʻohaʻahaʻa ʻana i ka matrix (hou, mua MMPs/Matrix Metalloproteinases) i kaohi pololei a i ole ia.
ʻO ka paʻa mīkini o ka ʻiʻo cartilage ka hopena o kēia hana a pau.
2.Hoʻolaha cartilage Hoʻohuihui
Hōʻike pū ʻo Cartalax i kahi mana kūʻokoʻa e hoʻomaikaʻi i ka metabolism anabolic tissue.
Hoʻoponopono chondrocyte hana hana, hoʻonui wikiwiki ia i ka synthesis a me ka huna ʻana o nā ʻāpana matrix extracellular; ʻO ka hoʻokumu ʻana o ka cartilage pololei ka hopena hope loa o kēia kaʻina hana.
Ua hōʻoia nā haʻawina in vitro i kēia hopena – ʻO nā chondrocytes i mālama ʻia a i ʻole nā pūnaewele stem e hōʻike ana i nā pae hōʻike gene i hoʻokiʻekiʻe ʻia o ke ʻano II collagen a aggrecan, me ka piʻi like ʻana o ka hana maoli o ia mau protein.
Loaʻa ka hoʻomaikaʻi ʻole ʻana o ka metabolism cellular a me ka synthesis protein ma o nā ala hōʻailona intracellular kikoʻī (TGF-β/ʻO Smad kahi kumu hoʻohālike); ʻo ka hoʻoulu hou ʻana o ka ʻiʻo ka hopena i makemake ʻia.
ʻO ka hoʻoponopono ʻana i ka microdamage mua a me ke kūkulu ʻana i kahi matrix hana ʻelua mau ala waiwai i hiki i kēia laina hana..
3.Nā hopena anti-inflammatory a me Immunomodulatory
NF-κB lawelawe ʻo ia i hōʻailona koʻikoʻi no ka hoʻoulu ʻana i nā mea inflammatory lehulehu.
Kāohi ikaika ʻo Cartalax, a i ʻole e hōʻemi iki, Hōʻike NF-κB – paʻi i ke kumu o ka hapa nui o nā pane inflammatory.
ʻeha, ʻO ka pehu a me ka ʻoʻoleʻa mau loa e pili ana me ka mumū e hoʻopau maikaʻi ʻia.
ʻO nā hopena pale cartilage i hōʻike ʻia ma luna nei he ʻāpana o kēia kaʻina anti-inflammatory; ʻO ka hoʻohaʻahaʻa ʻana i ka mumū he ʻano kumu o ka hana holoʻokoʻa o Cartalax.
COA
HPLC
MS
