Hōʻike ʻo NA Selank Amidate i ka hoʻomaikaʻi ʻana i ke kūpaʻa molecular a me ka vivo pharmacokinetic profile ma o ka hoʻolālā hoʻololi pālua o N-terminal acetylation a me C-terminal amidation e pili ana i ka hana kumu o Selank.
Hoʻonui kēia i ka hapalua o ke ola, hoʻonui ʻia pale koko-lolo pono komo, a me ka bioactivity lōʻihi ma nā ʻano molekala a me nā holoholona.
Eia kekahi, Hōʻike ikaika ʻo NA Selank Amidate immunomodulation a me ka hana anti-stress.
Kaʻina
ac-thr-lys-pro-arg-pro-gly-pro-nh2
Helu CAS
/
ʻĀpana Molekala
C35H60N12O9
Kaumaha Molecular
792.94
Noiʻi o NA Selank Amidate
1.Paʻa a hoʻonui i ka pono
ʻO ka pono-naʻauao,Mālama ʻo NA Selank Amidate i nā ʻano āpau o Selank, hooponopono ana ʻakika gamma-aminobutyric (GABA) neurotransmission i loko o ka lolo me ka hoʻololi ʻana i ka dopaminergic a serotonergic nā ʻōnaehana e hāʻawi maikaʻi anxiolytic a antidepressant hopena.
Hōʻike pū ia i ka maikaʻi ʻoi aku ka maikaʻi ma mua o Selank i ka hoʻonui ʻana i nā hana cognitive a me neuroprotective, e hoʻopuka ana i nā hopena maikaʻi i ke aʻo ʻana, hoʻomanaʻo, a me ka noonoo.
2.Nā hopena anxiolytic a me ka hoʻopaʻa ʻana i ka naʻau
Ma kahi ʻano hilinaʻi a me subtype-koho, NA Selank Amidate allosterically modulates ka GABA-A mea hoʻokipa ma ka hoʻoikaika ʻana i ka pono paʻa o GABA i kāna mea loaʻa a hoʻonui paha chloride ion channel pono wehe.
Hoʻonui nui kēia i ka leo inhibitory i nā kaapuni lolo kī, ka hana ʻana i nā hopena anxiolytic.
Eia kekahi, ʻoi aku ka maʻalahi o nā hopena o kēia hana anxiolytic ma mua o nā lāʻau anxiolytic maʻamau, e hana ana iā NA Selank Amidate i mea hoʻohuihui hoʻopaʻa naʻau.
3.Hoʻonui i ka naʻau a me ka Neuroprotection
Hoʻōla pololei ʻo NA Selank Amidate BDNF gene transcription ma ka hooulu ana phosphorylation o ka mea hoʻolaha i loaʻa CREB mea unuhi a me ka acetylation o ka histone H3, hoʻonui i ka BDNF mRNA pae 3.2-fold i loko o ka hippocampal dentate gyrus granule cell a prefrontal cortical pyramidal neurons a me ka protein huna 2.8-fold i loko 24 hola.
Hoʻoikaika kēia i ka TrkB alaloa hōʻailona hōʻailona i lalo, hoʻokomo i ka Ras-MAPK a PI3K-Kanawai cascade e hoʻonui iwi kuamoʻo dendritic mānoanoa e 39%, upregulate synaptophysin olelo e 45%, a hoʻihoʻi hou i ka amplitude LTP i ka papa kuhikuhi.
Mālama maikaʻi kēia i ka hōʻeha hippocampal neuronal a me ka emi ʻana o ka cognitive, e hōʻike ana i nā waiwai neuroprotective ʻokoʻa.
4.Ka Immunomodulatory a me ka Anti-Stress Effects
ʻO NA Selank Amidate kahi mea hoʻokūkū hoʻokūkū o ka enkephalin-degrading enzyme, pale ʻana i ka endogenous nā peptide opioid mai hydrolysis a ma laila e hoʻokiʻekiʻe ai i ko lākou pae, oiai e keakea ana LPS (lipopolysaccharide)-hōʻike hoʻoulu ʻia o ka pro-inflammatory cytokines komo IL-6 a TNF-α e 40–60% in astrocytes.
Hoʻopiʻi pū ʻo NA Selank Amidate i ka unuhi nuklea NF-κB ma o ka hoʻopili ʻana i ka loaʻa ʻana o ka protein adapter MyD88., ka hāʻawi ʻana i ka hoʻoponopono palekana i ka microenvironment neuroinflammatory.
COA
HPLC
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