Selank, possessing the amino acid sequence H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, is a potent and long-lasting anti-anxiety drug.
Derived from the retention and subsequent modification of a tuftsin core fragment, this process significantly enhances its ability to cross the pale koko-lolo; unique central nervous system activity is a direct result of said modification.
Since the beginning of this century numerous clinical trials have been performed on Selank; complex pharmacological properties spanning multiple modalities and multiple potential targets have been documented.
A stable mechanism of action is what makes Selank particularly valuable; rebound effects do not occur upon discontinuation.
Neurological diseases benefit from a triple regulatory path: neurotransmitters, neuroplasticity and immune system regulation.
Kaʻina
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Helu CAS
129954-34-3
ʻĀpana Molekala
C33H57N11O9
Kaumaha Molecular
751.887
Research Of Selank
1.Mechanisms of Action and Therapeutic Effects
ʻO kāna hana koʻikoʻi ka hoʻoponopono ʻana i ke koena i loko o nā ʻōnaehana neurotransmitter kī i ka lolo.
Hoʻololi i ka hoʻoili ʻana o ʻakika γ-aminobutyric (GABA) kikoʻī, me nā hopena hoʻoponopono like ʻole ma serotonin a nā ʻōnaehana dopaminergic, alakaʻi i nā hopena anti-anxiety a me nā hopena antidepressant.
Ua hōʻike pū ʻia ka hoʻonui ʻia ʻana o ka hippocampal neuronal plasticity; hoonui noonoo (ao ana, hoʻohui hoʻomanaʻo, ʻo ka nānā ʻana he kumu hoʻohālike) pili i kēia laina hoʻoponopono.
ʻO ka paʻa ʻana o ke kumu tuftsin kumu e hiki ai i ka hana nui i ka hoʻoponopono ʻana i ke kūlana immune cellular, cytokines (interferon ʻo ia kekahi o nā mea i aʻo maikaʻi ʻia) – he hopena immunomodulatory hiki i ke kino ke hoʻohana i ke koʻikoʻi.
Kākoʻo nā haʻawina hoʻomaʻamaʻa i ka hoʻomaikaʻi ʻana i ke ʻano a me ka hoʻonui ʻana i ka noʻonoʻo noʻonoʻo e hoʻomaʻamaʻa ʻia e Selank.
2.Nā hopena anti-anxiety a me nā hopena antidepressant
ʻAʻole like me nā lāʻau anti-anxiety a me nā lāʻau antidepressant, ʻAʻole hana pololei ʻo selank i nā mea loaʻa GABA.
aka, hana ia ma ka hooponopono ana i na neurotransmitters nui i loko o ka lolo.
Ua hōʻike ʻia nā hoʻokolohua e hoʻomaikaʻi ʻo selank i ka pono o ka hoʻouna ʻana o kēia neurotransmitter hoʻopale, GABA; ke kāohi nei i ka hana neuronal nui a ma hope o ka hopohopo ka hopena mua o kēia kaʻina hana.
Hoʻoponopono hou aku i nā neurotransmitters – ʻO dopamine ke kumu hoʻohālike – hiki i ka selank ke hoʻonui nui i ke koʻikoʻi o ka ʻōnaehana nerve.
ʻO ke ʻano o ka naʻau a me nā manaʻo maikaʻi/ʻino o ka leʻaleʻa e hoʻomalu ʻia; hale paʻa, ʻO nā hopena anti-anxiety lōʻihi a me nā hopena antidepressant ka hopena.
Nā hopena ʻaoʻao kaulana (ka hiamoe, pilikia o ka naʻau, ʻO ka addiction ka mea i kākau maikaʻi ʻia) pale ʻia, ka hana ʻana i ka selank kahi lāʻau kū hoʻokahi no kekahi mau maʻi neurological.
3.Hoʻonui i ka hana Cognitive a me ka hoʻoikaika ʻana i ka Neuroplasticity
Ua hōʻike ʻo Selank i ka pono i ka hoʻonui ʻana i ka hana cognitive.
ʻO ke kumu neurotrophic no ka lolo (BDNF) ʻo ia ka manaʻo nui o kēia noiʻi; ʻO ka upregulation o kāna hana ke kikowaena o ke ola neuronal, ʻokoʻa a me nā ʻano like ʻole o ka synaptic plasticity.
Hōʻike kikoʻī nā pūnae Hippocampal i ka hoʻonui ʻana i ka hana pili BDNF ke mālama ʻia me ka selank.
Ua ʻike ʻia ka hoʻonohonoho hou ʻana o nā neural ma o nā pilina hou – hoʻohui hoʻomanaʻo, ʻoi aku ka maikaʻi o ke aʻo ʻana a me ka nānā ʻana.
Maikaʻi ka noʻonoʻo, ʻoi aku ka wikiwiki o ka ʻike a me nā hopena maikaʻi i nā hoʻokolohua cognitive ua hoʻopaʻa ʻia i nā maʻi.
4.Hoʻoponopono Pūnaehana Neuroimmune
ʻO Tuftsin kahi peptide kūlohelohe kūlohelohe.
Mālama ʻo Selank i kahi ʻāpana kumu o ka tuftsin, pela ka loaa ana o ka mana, ʻoiai maʻalahi, hopena immunomodulatory.
ʻO ka Neuromodulation a me kēia pilina neuro-immune he hoʻohui.
Hōʻike nā haʻawina koʻikoʻi koʻikoʻi iā Selank i kūpono loa i ka hoʻololi ʻana i ka noʻonoʻo a me ka physiological.
ʻO nā pane palekana i hoʻomaikaʻi ʻia a i ʻole ka liʻiliʻi loa e kōkua i ka hopena hopena o kēia mau mīkini.
ʻO ka maikaʻi o ka noʻonoʻo a me ke kino e pili pū ana.
5.Hiki ke mālama i ka maʻi obsessive-compulsive a me ka hoʻonāukiuki
Hōʻike kekahi mau hōʻike e pili ana ka selank i ka pilina ma waena o ka amygdala a poʻo mua; ʻO ka hoʻolaha ʻana i ka pau ʻana o ka makaʻu kekahi o nā hopena i ʻike pono ʻia.
ʻO ka maʻi obsessive-compulsive a me nā ʻano like ʻole o ka hoʻonāukiuki e hāʻule ma lalo o kēia ʻāpana ma ke ʻano he pahuhopu mua no ka mālama ʻana.
Ua hōʻike ʻia nā hoʻokolohua holoholona i ka hoʻohaʻahaʻa nui ʻana o ka hana hoʻoulu ʻana i ka huluhulu, he ana i hooiaioia o ka hoouluhua maemae.
Ua hoʻomaka ka poʻe ʻepekema e noʻonoʻo i nā hana ma hope o kēia – ʻO ka hoʻoponopono ʻana i kekahi ʻano o ka ʻōnaehana serotonin he kumu alakaʻi, Hoʻonui ʻia ka hoʻololi ʻana i ke kaumaha ma nā haʻawina he nui.
Ke hoʻomau nei ka noiʻi pili, akā he mea nui ka ʻimi ʻana i kēia mau lāʻau lapaʻau; ka mālama ʻana i nā maʻi i ʻōlelo ʻia aʻe nei (psychiatric a i ʻole) he pahuhopu nui a hiki ke hoʻokō.
COA
HPLC
MS
