Selank

瑟兰克

瑟兰克

瑟兰克, possessing the amino acid sequence H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, is a potent and long-lasting anti-anxiety drug.

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瑟兰克, possessing the amino acid sequence H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, is a potent and long-lasting anti-anxiety drug.

Derived from the retention and subsequent modification of a tuftsin core fragment, this process significantly enhances its ability to cross the 血脑屏障; unique central nervous system activity is a direct result of said modification.

Since the beginning of this century numerous clinical trials have been performed on Selank; complex pharmacological properties spanning multiple modalities and multiple potential targets have been documented.

A stable mechanism of action is what makes Selank particularly valuable; rebound effects do not occur upon discontinuation.

Neurological diseases benefit from a triple regulatory path: 神经递质, neuroplasticity and immune system regulation.

顺序

Thr-Lys-Pro-Arg-Pro-Gly-Pro

CAS 号

129954-34-3

分子式

C33H57N11O9

分子量

751.887

Research Of Selank

1.作用机制和治疗效果

Its core function is the regulation of the balance within key neurotransmitter systems in the brain.

Modulating the transmission of γ-aminobutyric acid (氨基丁酸) 具体来说, along with various regulatory effects on serotonin and dopaminergic systems, leads to excellent anti-anxiety and antidepressant effects.

Enhanced hippocampal neuronal plasticity has also been shown; cognitive enhancement (learning, memory consolidation, attention being prime examples) is at least partially attributable to this line of regulation.

The retention of the original tuftsin core allows for significant efficacy in regulating the cellular immune status, 细胞因子 (interferon being one of the better studied) – an immunomodulatory effect the body can use to cope with various stress.

Clinical studies support the improvement of mood and enhanced psychological resilience that Selank facilitates.

2.Anti-anxiety and antidepressant effects

Unlike traditional anti-anxiety and antidepressant drugs, selank does not act directly on GABA receptors.

反而, it works by regulating various key neurotransmitters within the brain.

Experiments have shown that selank enhances the transmission efficiency of this inhibitory neurotransmitter, 氨基丁酸; inhibiting excessive neuronal activity and subsequently anxiety being the primary outcome of this process.

Further regulation of neurotransmitters – dopamine being a prime example – allows selank to significantly increase the nervous system’s stress resilience.

Mood swings and associated positive/negative feelings of pleasure are at least partially controlled; 稳定的, long term anti-anxiety and antidepressant effects are the result.

Notable side effects (drowsiness, cognitive impairment, addiction being the most well documented) are avoided, making selank a uniquely positioned treatment for certain neurological diseases.

3.Enhancing Cognitive Function and Promoting Neuroplasticity

Selank has demonstrated efficacy in enhancing cognitive function.

Brain Derived Neurotrophic Factor (脑源性神经营养因子) is the focus of much of this research; upregulation of its activity is central to neuronal survival, differentiation and all forms of synaptic plasticity.

Hippocampal cells specifically show increased BDNF related activity when treated with selank.

Neural reorganization through new connections has been observed – memory consolidation, learning ability and attention/concentration all improve.

Clearer thinking, faster information processing and positive results in cognitive tests have all been recorded in patients.

4.Neuroimmune System Regulation

Tuftsin is a natural immune peptide.

Selank retains a core fragment of tuftsin, thus possessing a powerful, though subtle, immunomodulatory effect.

Neuromodulation and this neuro-immune interaction are complementary.

Chronic stress studies show Selank to be particularly well suited to psychological and physiological adaptation.

Improved or at least balanced immune responses contribute to the end result of these mechanisms.

Psychological and physical well-being are interdependent.

5.Potential for treating obsessive-compulsive disorder and agitation

Some reports indicate that selank influences the connection between the amygdala 和 prefrontal cortex; promoting fear extinction being one of the more directly observable effects.

Obsessive-compulsive disorder and various forms of agitation fall under this category as primary targets for treatment.

Animal experiments have shown a significant reduction of agitation-induced fur-puffing behavior, a validated measure of pure agitation.

Scientists have begun to speculate the mechanisms behind this – regulation of at least some aspect of the serotonin system being a leading theory, stress adaptation being enhanced in multiple studies.

Related research is still ongoing, but exploring these potential lines of treatment is important; treating the aforementioned diseases (psychiatric or otherwise) remains a significant and achievable goal.

COA

高效液相色谱法

多发性硬化症

(1) 我们想要, C. R。; 白色的, C. 中号. 影响γ-氨基丁酸受体的镇静催眠药: 关注氟硝西泮, γ-羟基丁酸, 苯丁酸, 和塞兰克. 临床药理学杂志 2021, 61 补充 2, S114-S128. DOI: 10.1002/jcph.1922 From NLM Medline.

(2) 可怜的东西, 一个。; 科洛明, T。; 安德烈耶娃, L。; 邦达连科, E.; 米亚索耶多夫, N。; 斯洛明斯基, P。; 沙德里娜, 中号. 肽 Selank 增强地西泮减轻大鼠不可预测的慢性轻度应激状态焦虑的作用. 行为神经学 2017, 2017, 5091027. DOI: 10.1155/2017/5091027 来自 NLM Medline.

(3) 别针, L. G。; 纳多罗娃, 一个. 五、; 安蒂波娃, 时间. 一个。; 克鲁格洛夫, S. 五、; 库德林, V. S。; 杜尔内夫, 一个. D. 瑟兰克, Tuftsin 肽类似物, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. 公牛实验生物医学 2019, 167 (5), 641-644. DOI: 10.1007/s10517-019-04588-9 From NLM Medline.

(4) 别针, L. G。; 纳多罗娃, 一个. 五、; 塞瑞德宁, S. 乙. Selank 抑制 DBA/2 小鼠乙醇诱导的过度运动和行为敏感化表现. 公牛实验生物医学 2016, 162 (1), 56-59. DOI: 10.1007/s10517-016-3544-6 来自 NLM Medline.

(5) 成本, 氮. 五、; 索科洛夫, 奥。; 加巴耶娃, 中号. 五、; 格里文尼科夫, 我. 一个。; 安德烈耶娃, L. 一个。; 米亚索耶多夫, 氮. F。; 佐祖利亚, 一个. 一个. [Semax 和 selank 抑制人血清中的脑啡肽降解酶]]. 比奥·金 2001, 27 (3), 180-183. DOI: 10.1023/一个:1011373002885 来自 NLM Medline.

(6) 我不知道, G. G。; 泰莱绍娃, 乙. S。; 博奇卡列夫, V. K.; 科舍列夫, V. 五、; 休尼亚科夫, 时间. S. P.3.036 新型抗焦虑药物 Selank: II期临床试验结果. 欧洲神经精神药理学 2005, 15, S159-S160. DOI: 10.1016/S0924-977x(05)80332-3.

(7) 斯洛明斯基, 磷. 一个。; 沙德里娜, 中号. 我。; 科洛明, 时间. 一个。; 斯塔夫罗夫斯卡娅, 一个. 五、; 菲拉托娃, 乙. 五、; 安德烈耶娃, L. 一个。; 伊拉里奥什金, S. N。; 米亚索耶多夫, 氮. F. 肽semax和selank影响6-OHDA诱导的PD样帕金森病大鼠的行为. Dokl Biol Sci 2017, 474 (1), 106-109. DOI: 10.1134/S0012496617030048 From NLM Medline.

(8) 索勒廷斯卡娅, 时间. N。; 肖罗霍夫, 中号. 五、; 米亚索耶多夫, 氮. F. Semax和Selank对灵长类动物不同类型神经症的脑保护作用. 国际心理生理学杂志 2008, 69 (3). DOI: 10.1016/j.ijpsycho.2008.05.356.

(9) Sollertinskaya, 时间. N。; Shorokhov, 中号. 五、; Kozlovskaya, 中号. M。; Kozlovskii, 我. 我。; Sudakov, K. V. Compensatory and antiamnestic effects of heptapeptide Selank in monkeys. Journal of Evolutionary Biochemistry and Physiology 2008, 44 (3), 332-340. DOI: 10.1134/s0022093008030101.

顺序:

Thr-Lys-Pro-Arg-Pro-Gly-Pro

中科院:

129954-34-3

分子量:

751.887 克/摩尔

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