Delta tsaug zog-inducing peptide (DSIP) yog ib tug active lom neuropeptide muaj cuaj amino acids. Qhov kev tshawb pom ntawm DSIP sawv cev rau kev hloov pauv hauv kev nkag siab ntawm kev tswj kev pw tsaug zog - los ntawm cov qauv qub dhau los ntawm lub hauv nruab nrab nuclei unilaterally tswj kev pw tsaug zog kom paub txog lub luag haujlwm ua los ntawm cov tswj kev pw tsaug zog endogenous..
Cov peptide no nthuav tawm dav physiological functions thiab ib tug txawv mechanism ntawm kev txiav txim. Nws muaj peev xwm hla tau sai heev ntshav-hlwb barrier(BBB) yog ib qho ntawm nws cov khoom tseem ceeb; nws kev koom tes nyob rau hauv regulating lub hypothalamic-pituitary-adrenal (HPA) axis thiab muaj kev cuam tshuam rau systemic homeostasis yog tag nrho cov ntaub ntawv zoo.
Tshaj nws cov tseem ceeb pw tsaug zog-regulating functions (pw tsaug zog txhawb nqa, txhim kho kev pw tsaug zog architecture, thiab txhim khu kev pw tsaug zog zoo), DSIP qhia muaj zog neuroprotective thiab, mus rau qhov tseem ceeb, muaj peev xwm kho tau. Txhim kho neuronal tsis kam mus rau ntau hom kev overstimulation yog ib qho piv txwv tseem ceeb ntawm qhov no.
Kev tswj hwm endocrine thiab thermoregulation kuj tau tsim cov haujlwm ntawm DSIP. Tsis ntev los no, antioxidant thiab detoxification kev ua ub ua no tau pom.
Ib ntus
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
CAS Nr
62568-57-4
Molecular Formula
C35H48N10O15
Molecular Luj
848.33
Kev tshawb fawb ntawm Delta tsaug zog Inducing peptide (DSIP)
1.Pw tsaug zog-Inducing Effects
Kev tswj kev pw tsaug zog yog qhov tseem ceeb tshaj plaws uas feem ntau cuam tshuam nrog DSIP. Muaj zog thiab xaiv kev txhawb nqa ntawm pw tsaug zog qeeb yog nws qhov kev tshaj tawm zoo tshaj plaws. Ib txwm exogenous pw tsaug zog pab ua haujlwm los ntawm kev sib txawv kiag li; DSIP, raws li endogenous neuroregulatory peptide, physiologically modulates (nyob rau hauv ib tug zoo zam) tus neeg siv pw tsaug zog architecture. Ua kom lub sijhawm pw tsaug zog ntau dua yog qhov sib txuas ncaj qha ntawm kev txhim kho kev pw tsaug zog zoo.
Ib qho kev kawm uas muaj 400 cov neeg mob mob hnyav insomnia, uas tau txais kev txhaj tshuaj DSIP tas li rau ib lub lis piam, pom kev txhim kho tseem ceeb hauv txhua qhov ntsuas ntawm kev pw tsaug zog zoo. Cov neeg mob nrog neurotic irritability, tshwj xeeb, pom tau tias muaj kev nce ntxiv hauv kev hloov pauv mus rau sab nraud stimuli tom qab txhaj tshuaj.
Cov txiaj ntsig no qhia txog DSIP lub luag haujlwm tseem ceeb hauv kev tswj kev pw tsaug zog thiab nws lub peev xwm los kho cov kab mob hauv lub paj hlwb.
2.Lub cev kub thiab lub cev muaj zog txoj cai
Qee cov tshuaj uas txhim kho lub hlwb dopamine tuaj yeem hloov lub cev kub. DSIP cuam tshuam nrog cov tshuaj no, inducing cov kev hloov uas tau hais los saum no.
Cov kev tshawb fawb hauv nas tau pom tias qhov koob tshuaj me me mus rau nruab nrab ntawm DSIP txo qis kev ua haujlwm ntawm lub cev thiab lub cev kub hauv qab 4 ° C..
Thaum cov nas raug xa rov qab mus rau ib puag ncig 22 ° C, Kev tswj hwm DSIP tau cuam tshuam nrog kev nce hauv lub cev kub.
3.Endocrine Regulatory Function
HPA axis yog qhov tseem ceeb neuroendocrine system rau kev ntxhov siab ntawm lub cev.
Overactivation ntawm qhov system no ua rau txawv txav, mob ntev nce qib cortisol. DSIP tiv thaiv cov nyhuv no los ntawm inhibiting CRH thiab ACTH tso tawm.
4.Neuroprotective thiab Reparative Functions
DSIP tau pom tias muaj kev tiv thaiv neuroprotective thiab reparative zog uas sawv cev rau ib qho tseem ceeb ntawm nws cov peev xwm kho mob..
Nws qhia tau hais tias cog lus rau kev kho mob ntawm Cov kab mob neurodegenerative , ntawm lwm yam mob.
COA
HPLC
MS
