DSIP

Delta sleep-inducing peptide (DSIP) is a biologically active neuropeptide composed of nine amino acids. The discovery of DSIP represented a shift in the understanding of sleep regulation—from the previous paradigm of specific central nuclei unilaterally controlling sleep to the recognition of the role played by endogenous sleep regulators.

This peptide exhibits broader physiological functions and a distinct mechanism of action. Its ability to rapidly cross the blood-brain barrier(BBB) is one of its notable properties; its participation in regulating the hypothalamic-pituitary-adrenal (HPA) axis and influence on systemic homeostasis are all well-documented effects.

Beyond its core sleep-regulating functions (deep sleep promotion, improved sleep architecture, and enhanced sleep quality), DSIP displays strong neuroprotective and, to a significant extent, reparative capabilities. Improving neuronal resistance to various forms of overstimulation is a key example of this.

Endocrine regulation and thermoregulation are also established activities of DSIP. More recently, antioxidant and detoxification activities have been observed.

序列

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

化学文摘社编号

62568-57-4

分子式

C35H48N10O15

分子量

848.33

Research Of Delta Sleep Inducing peptide (DSIP)

1.The Sleep-Inducing Effects

Sleep regulation is the primary function most commonly associated with DSIP. A potent and selective promotion of slow-wave sleep is its most consistently reported effect. Traditional exogenous sleep aids work through completely different mechanisms; DSIP, as an endogenous neuroregulatory peptide, physiologically modulates (in a well-tolerated manner) the user’s sleep architecture. Increasing the duration of deep sleep is a direct correlate of improved sleep quality.

A study involving 400 patients suffering from severe insomnia, who received continuous DSIP injections for a week, showed significant improvements in all measured aspects of sleep quality. Patients with neurotic irritability, in particular, showed a marked increase in adaptability to external stimuli post-injection.

These results underscore DSIP’s powerful role in sleep regulation and its potential in treating neurological disorders.

2.Body Temperature and Motor Function Regulation

Certain drugs that enhance brain dopamine activity can alter body temperature. DSIP interacts with these drugs, inducing the aforementioned changes.

Studies in mice showed that small to moderate doses of DSIP reduced motor activity and body temperature under 4°C conditions.

When mice were returned to a 22°C environment, DSIP administration was associated with an increase in body temperature.

3.Endocrine Regulatory Function

The HPA axis is the core neuroendocrine system for the body’s stress response.

Overactivation of this system leads to abnormal, chronically elevated cortisol levels. DSIP counteracts this effect by inhibiting CRH and ACTH release.