LL-37 yog antimicrobial peptide los ntawm cathelicidin tsev neeg. Lub npe nws tus kheej hais txog nws 37 amino acid muaj pes tsawg leeg thiab N-terminal pib ntawm ob leucine cov seem. PAB 18, ib tug tswv cuab ntawm tib neeg cathelicidin tsev neeg, undergoes tshwj xeeb cleavage los ntawm tib neeg proteases tso tawm no biologically nquag nquag LL-37 fragment.
Qhov kev tshawb pom ntawm LL-37 tau cim qhov kev hloov pauv ntawm kev tshawb fawb cathelicidin los ntawm cov qauv tsiaj rau tib neeg.. Raws li ib feem tseem ceeb ntawm lub cev tiv thaiv kab mob, LL-37 plays lub luag haujlwm tseem ceeb hauv tib neeg kev tiv thaiv kab mob.
Lub luag haujlwm tseem ceeb ntawm kev tiv thaiv no yog dav-spectrum ncaj qha kev ua haujlwm ntawm cov kab mob. Lub amphipathic α-helical(Alpha helix) qauv lub luag hauj lwm rau qhov kev ua si no induces electrostatic attraction ntawm cov kab mob uas tsis zoo them cov kab mob. Kev cuam tshuam ncaj qha ntawm membrane kev ncaj ncees ua rau poob ntawm cov as-ham intracellular; ua tiav cov kab mob tuag raws li. Qhov tseem ceeb, no mechanism tsis induce ib hom kev tiv thaiv.
Lwm cov haujlwm hauv lub cev kuj raug ntaus nqi rau nws – kho qhov txhab, kho cov ntaub so ntswg, muaj zog immunomodulation, endotoxin neutralization, thiab ua kom pom kev tiv thaiv kab mob qog noj ntshav thiab tiv thaiv kab mob.
Ib ntus
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Glu-AV-Asn
CAS Nr
154947-66-7
Molecular Formula
C205H340N60O53
Molecular Luj
4493.34
LL-37 Kev tshawb fawb ntsig txog
1.Broad-Spectrum Direct Antibacterial Activity
Ceev ceev thiab ncaj qha bactericidal txiav txim tawm tsam ntau yam kab mob yog LL-37 cov ntaub ntawv zoo tshaj plaws. Gram tsis zoo, zoo, thiab txawm ib co fungal kab mob raug tua tag nrho.
Cov cationic, amphipathic yam ntxwv ntawm peptide yog qhov tseem ceeb rau txoj kev no; cov nqi them ncaj qha mus rau cov kab mob kab mob. Kev nkag mus ntawm cov ntsiab lus ntawm tes thiab kev sib tsoo ntawm daim nyias nyias muaj peev xwm yog qhov kawg ntawm kev tawm tsam.
Cov tshuaj tua kab mob ib txwm ua haujlwm los ntawm kev sib txawv heev (thiab feem ntau lub hom phiaj tshwj xeeb) txoj kev tiv thaiv; LL-37 hom kev tawm tsam yog ob qho tib si ceev thiab, mus rau hnub tim, tsis cuam tshuam nrog kev txhim kho tseem ceeb. Tib neeg cov kev tshawb fawb soj ntsuam txhawb kev nyab xeeb thiab kev ua tau zoo ntawm LL-37 ua tus kws kho mob.
2.Hwj chim Immunomodulatory Function
LL-37 exerts nws cov teebmeem raws li lub zos microenvironment hauv lub cev. Thaum kuaj pom cov ntaub so ntswg raug mob los yog kev hloov pauv pathological, LL-37 qhib ntau yam kev tswj hwm thiab cov hlwb kom sib sau ua ke ntawm cov chaw no.
Kev hloov pauv ntawm inflammatory cytokine tso tawm yog ib qho ntawm nws txoj hauv kev; Cov lus teb pro-inflammatory ntau dhau yog tshwj xeeb txo qis. Txhawb nqa dendritic cell(DC) maturation thiab tom qab T cell kev sib txawv yog lwm qhov tseem ceeb ntawm cov txheej txheem no – sawv cev rau tus choj tseem ceeb ntawm innate thiab adaptive tiv thaiv.
3.Txhawb Kev Kho Hniav thiab Kho daim ntaub so ntswg
LL-37 lub qhov txhab kho thiab kho cov ntaub so ntswg muaj peev xwm txuas ncaj qha rau nws cov haujlwm immunomodulatory., nrog rau kev ua haujlwm ncaj qha tshuaj tiv thaiv kab mob.
Activation ntawm antimicrobial txoj kev induces keratinocytes, fibroblasts, thiab cov hlwb endothelial tsiv mus rau qhov chaw mob; cell proliferation ua raws li kev puas tsuaj raug kho. Angiogenesis muab ob qho tib si lub zog thiab cov zaub mov xa mus rau cov ntaub so ntswg raug mob.
4.Anti-cancer Activity
Cov kab mob qog noj ntshav feem ntau qhia cov yam ntxwv ntawm kev nthuav tawm ntau yam tsis zoo phosphatidylserine nyob rau ntawm lawv daim nyias nyias (ib txwm cell muaj internal localization ntawm cov no phospholipids). Tus nqi zoo ntawm LL-37 yog li nyiam rau lawv.
Apoptosis thiab necrotic txoj kev tuag zoo ib yam li cov siv tiv thaiv kab mob yog pib. Tsis ncaj tshuaj tiv thaiv qog cuam tshuam los ntawm kev tiv thaiv kab mob kuj tseem ua ib feem.
Cov kev tshawb fawb ua ntej tau pom qhov txo qis hauv cov qog nqaij hlav cancer kho nrog LL-37; Kev kho mob qog noj ntshav siv LL-37 yog thaj chaw muaj txiaj ntsig ntawm kev tshawb fawb.
COA
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