Myristoyl pentapeptide-17 is a bioactive peptide specifically designed and synthesized to address the insufficient growth of natural eyelashes/hair.
Derived from a 14-18 amino acid fragment of human keratin-associated protein KAP5-1, it undergoes N-terminal მირისტოილაცია and C-terminal amidation; this enhances its half-life, allowing for direct penetration of human epidermal cell membranes.
Myristoyl pentapeptide-17 is currently one of the more potent cosmetic peptides used to stimulate eyelash growth, widely incorporated into numerous beauty products.
თანმიმდევრობა
Myr-Lys-Leu-Ala-Lys-Lys-NH2
CAS ნომერი
959610-30-1
მოლეკულური ფორმულა
C41H81N9O6
მოლეკულური წონა
796.16
Myristoyl Pentapeptide-17 Related Research
1.Primary Biological Mechanisms
Improved delivery efficiency of KGF(Keratinocyte Growth Factor), VEGF(Vascular Endothelial Growth Factor) და lysophosphatidic acid (LPA) is facilitated within these cells, prolonging the hair growth cycle.
Anti-inflammatory properties are also exhibited, making it suitable for sparse eyebrows, and as an adjunct treatment of ანდროგენული ალოპეცია; ფოტოდაბერება around the eyes being a primary concern.
ხელშეწყობა follicular blood circulation is another key effect – enhanced blood flow to the hair follicles means increased nutrient and oxygen delivery, creating an ideal nutritional environment for eyelash growth.
2.ზერეგულაცია კერატინი გენის გამოხატულება
The active fragment mentioned above retains the core function of the original KAP proteins(Keratin Associated Proteins).
Binding to cationic amino acid transporters, transcription and subsequent synthesis of KAP5-1 and Type I keratins (31 being the most well documented) is upregulated.
Thickening of the hair shaft cortex is the physical manifestation of this process, eyelash resilience being significantly increased.
3.ხელშეწყობა microcirculation/nutrient supply
Myristoyl pentapeptide-17 stimulates კერატინოციტები to release VEGF-A და basic fibroblast growth factors(bFGF or FGF2).
Rapid membrane penetration leads to dermal microvessel vasodilation, improved blood flow, გაძლიერებული intercellular nutrient exchange and increased nutrient supply to the follicle.
Anti-inflammatory effects are all part of a larger, self-sustaining process of skin barrier repair.
Shortening the resting phase of the hair follicle and promoting eyelash health, is the end result of Myristoyl Pentapeptide-17’s actions.
COA
HPLC
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