Myristoyl pentapeptide-17 is a bioactive peptide specifically designed and synthesized to address the insufficient growth of natural eyelashes/hair.
Derived from a 14-18 アミノ酸 fragment of human keratin-associated protein KAP5-1, it undergoes N-terminal myristoylation and C-terminal アミド化; this enhances its half-life, allowing for direct penetration of human epidermal 細胞膜.
Myristoyl pentapeptide-17 is currently one of the more potent cosmetic peptides used to stimulate eyelash growth, widely incorporated into numerous beauty products.
順序
ミル-リス-ロイ-アラ-リス-リス-NH2
CAS番号
959610-30-1
分子式
C41H81N9O6
分子量
796.16
Myristoyl Pentapeptide-17 Related Research
1.Primary Biological Mechanisms
Improved delivery efficiency of KGF(Keratinocyte Growth Factor), VEGF(Vascular Endothelial Growth Factor) そして lysophosphatidic acid (LPA) is facilitated within these cells, prolonging the hair growth cycle.
Anti-inflammatory properties are also exhibited, making it suitable for sparse eyebrows, and as an adjunct treatment of 男性型脱毛症; 光老化 around the eyes being a primary concern.
推進する follicular blood circulation is another key effect – enhanced blood flow to the hair follicles means increased nutrient and oxygen delivery, creating an ideal nutritional environment for eyelash growth.
2.のアップレギュレーション ケラチン 遺伝子発現
The active fragment mentioned above retains the core function of the original KAP proteins(Keratin Associated Proteins).
Binding to cationic amino acid transporters, transcription and subsequent synthesis of KAP5-1 and Type I keratins (31 being the most well documented) is upregulated.
Thickening of the hair shaft cortex is the physical manifestation of this process, eyelash resilience being significantly increased.
3.推進する microcirculation/nutrient supply
Myristoyl pentapeptide-17 stimulates ケラチノサイト to release VEGF-A そして basic fibroblast growth factors(bFGF or FGF2).
Rapid membrane penetration leads to dermal microvessel vasodilation, improved blood flow, 強化された intercellular nutrient exchange and increased nutrient supply to the follicle.
Anti-inflammatory effects are all part of a larger, self-sustaining process of skin barrier repair.
Shortening the resting phase of the hair follicle and promoting eyelash health, is the end result of Myristoyl Pentapeptide-17’s actions.
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