Delta peptide yochititsa kugona (DSIP) ndi biologically yogwira neuropeptide wopangidwa ndi ma amino acid asanu ndi anayi. Kupezeka kwa DSIP kunayimira kusintha kwa kamvedwe kakuwongolera kugona —kuchokera pamalingaliro am'mbuyomu apakati enieni apakati omwe amawongolera tulo mpaka kuzindikira gawo lomwe owongolera amagonedwe amkati..
Peptide iyi imawonetsa magwiridwe antchito ochulukirapo komanso njira ina yochitira zinthu. Kutha kwake kudutsa mwachangu magazi-ubongo chotchinga(BBB) ndi chimodzi mwazinthu zake zodziwika bwino; kutenga nawo gawo pakuwongolera hypothalamic-pituitary-adrenal (HPA) olamulira ndi chikoka pa systemic homeostasis zonse zolembedwa bwino.
Kupitilira ntchito zake zazikulu zowongolera kugona (kukwezedwa kwa tulo tozama, kamangidwe kabwino ka kugona, komanso kugona bwino), DSIP imawonetsa ma neuroprotective amphamvu komanso, kwambiri, kukonzanso luso. Kupititsa patsogolo kukana kwa neuronal ku mitundu yosiyanasiyana ya kukondoweza ndi chitsanzo chachikulu cha izi.
Endocrine regulation ndi thermoregulation ndi ntchito zokhazikitsidwa za DSIP. Posachedwapa, antioxidant ndi kuchotsa poizoni ntchito zawonedwa.
Kutsatizana
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Nambala ya CAS
62568-57-4
Molecular Formula
Chithunzi cha C35H48N10O15
Kulemera kwa Maselo
848.33
Research Of Delta Sleep Inducing peptide (DSIP)
1.Zotsatira Zoyambitsa Tulo
Kuwongolera tulo ndiye ntchito yayikulu yomwe imalumikizidwa kwambiri ndi DSIP. Kutsatsa kwamphamvu komanso kosankha kwa kugona pang'onopang'ono ndiye zotsatira zake zomwe zimanenedwa mosasintha. Zothandizira zachikhalidwe zakugona zimagwira ntchito mosiyanasiyana; DSIP, monga endogenous neuroregulatory peptide, physiologically modulates (m'njira yabwino) kamangidwe ka kugona kwa wogwiritsa ntchito. Kuchulukitsa nthawi yakugona mozama ndikulumikizana mwachindunji kwa kugona bwino.
Kafukufuku wokhudza 400 odwala omwe akuvutika kwambiri kusowa tulo, amene adalandira jakisoni wa DSIP mosalekeza kwa sabata, adawonetsa kusintha kwakukulu pazigawo zonse zoyesedwa za khalidwe la kugona. Odwala ndi neurotic irritability, makamaka, adawonetsa kuwonjezeka kwakukulu kwa kusinthika kwa zokopa zakunja pambuyo jekeseni.
Zotsatira izi zikugogomezera gawo lamphamvu la DSIP pakuwongolera kugona komanso kuthekera kwake pochiza matenda amisempha..
2.Kutentha kwa Thupi ndi Kuwongolera Ntchito Yagalimoto
Mankhwala ena omwe amachititsa kuti ubongo ukhale ndi dopamine amatha kusintha kutentha kwa thupi. DSIP imalumikizana ndi mankhwalawa, kuyambitsa zosintha zomwe tazitchulazi.
Kafukufuku wa mbewa adawonetsa kuti milingo yaying'ono mpaka yocheperako ya DSIP imachepetsa zochitika zamagalimoto ndi kutentha kwa thupi pansi pa 4 ° C..
Pamene mbewa zinabwezeretsedwa ku malo a 22 ° C, Ulamuliro wa DSIP unagwirizanitsidwa ndi kuwonjezeka kwa kutentha kwa thupi.
3.Endocrine Regulatory Function
Mzere wa HPA ndiye maziko neuroendocrine system chifukwa cha kupsinjika kwa thupi.
Kuchuluka kwa dongosolo lino kumabweretsa zachilendo, kuchuluka kwa cortisol nthawi zonse. DSIP imalimbana ndi izi poletsa kutulutsidwa kwa CRH ndi ACTH.
4.Ntchito za Neuroprotective ndi Reparative
DSIP yawonetsa ma neuroprotective ndi reparative properties zomwe zimayimira mbali yofunika kwambiri pakuchiritsa kwake.
Zimasonyeza lonjezo la chithandizo cha matenda a neurodegenerative , mwa zina.
COA
Mtengo wa HPLC
MS
