Selank, kukhala ndi mndandanda wa amino acid H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, ndi mankhwala amphamvu komanso okhalitsa oletsa nkhawa.
Kuchokera pakusungidwa ndi kusinthidwa kotsatira kwa a tuftsin core fragment, ndondomeko imeneyi kwambiri timapitiriza luso lake kuwoloka magazi-ubongo chotchinga; wapadera chapakati mantha dongosolo ntchito ndi mwachindunji chifukwa cha anati kusinthidwa.
Kuyambira kumayambiriro kwa zaka za zana lino mayesero ambiri azachipatala achitidwa pa Selank; Zovuta za pharmacological zokhala ndi njira zingapo komanso zolinga zingapo zomwe zingatheke zalembedwa.
Njira yokhazikika yochitira zinthu ndi yomwe imapangitsa Selank kukhala yofunika kwambiri; zotsatira zobwereranso sizichitika pakusiya.
Matenda a mitsempha amapindula ndi njira yoyendetsera katatu: ma neurotransmitters, neuroplasticity ndi dongosolo la chitetezo cha mthupi.
Kutsatizana
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Nambala ya CAS
129954-34-3
Molecular Formula
Chithunzi cha C33H57N11O9
Kulemera kwa Maselo
751.887
Kafukufuku wa Selank
1.Njira Zochita ndi Zochizira
Ntchito yake yayikulu ndikuwongolera kusanja mkati mwa machitidwe ofunikira a neurotransmitter muubongo.
Modulating kufala kwa γ-aminobutyric acid (GABA) makamaka, pamodzi ndi zotsatira zosiyanasiyana zoyendetsera serotonin ndi dopaminergic machitidwe, kumabweretsa zabwino zotsutsana ndi nkhawa komanso antidepressant zotsatira.
Kupangidwanso kwa hippocampal neuronal plasticity kwawonetsedwanso; kuwonjezereka kwachidziwitso (kuphunzira, kuphatikiza kukumbukira, chisamaliro kukhala zitsanzo zazikulu) zimatheka chifukwa cha malamulowa.
Kusungidwa kwapachiyambi cha tuftsin kumapangitsa kuti pakhale mphamvu yoyendetsera chitetezo cha mthupi., cytokines (interferon kukhala m'modzi mwa ophunzitsidwa bwino) – mphamvu ya immunomodulatory yomwe thupi lingagwiritse ntchito kuthana ndi zovuta zosiyanasiyana.
Maphunziro azachipatala amathandizira kuwongolera kwamalingaliro komanso kukhazikika kwamalingaliro komwe Selank amathandizira.
2.Anti-nkhawa ndi antidepressant zotsatira
Mosiyana ndi chikhalidwe odana ndi nkhawa ndi antidepressant mankhwala, selank sichichita mwachindunji pa GABA receptors.
M'malo mwake, imagwira ntchito powongolera ma neurotransmitters osiyanasiyana muubongo.
Kuyesera kwawonetsa kuti selank imathandizira kufalikira kwa izi inhibitory neurotransmitter, GABA; kuletsa kuchitapo kanthu mopitirira muyeso kwa neuronal ndipo kenako nkhawa kukhala zotsatira zoyambirira za njirayi.
Kuwongolera kwina kwa ma neurotransmitters – dopamine ndiye chitsanzo chabwino – zimathandiza kuti selank iwonjezere kwambiri kupsinjika kwa dongosolo lamanjenje.
Kusintha kwamalingaliro ndi malingaliro abwino/oipa okhudzana ndi chisangalalo zimayendetsedwa pang'ono; khola, zotsatira za nthawi yayitali zotsutsana ndi nkhawa ndi antidepressant ndizotsatira.
Zotsatira zodziwika bwino (kugona, kuwonongeka kwachidziwitso, kuledzera kukhala cholembedwa bwino kwambiri) amapewa, kupanga selank kukhala chithandizo chapadera cha matenda ena amisempha.
3.Kupititsa patsogolo Ntchito Yachidziwitso ndi Kulimbikitsa Neuroplasticity
Selank wawonetsa kuchita bwino pakupititsa patsogolo ntchito zamaganizidwe.
Ubongo Wochokera ku Neurotrophic Factor (Mtengo wa BDNF) ndiye cholinga chachikulu cha kafukufukuyu; Kuwongolera ntchito yake ndikofunikira pakupulumuka kwa neuronal, kusiyanitsa ndi mitundu yonse ya synaptic plasticity.
Maselo a Hippocampal amawonetsa makamaka ntchito yokhudzana ndi BDNF ikathandizidwa ndi selank.
Kukonzanso kwa Neural kudzera m'malumikizidwe atsopano kwawonedwa – kuphatikiza kukumbukira, luso la kuphunzira ndi chidwi / kuika maganizo onse patsogolo.
Kuganiza bwino, kukonza chidziwitso chofulumira komanso zotsatira zabwino pakuyezetsa kwachidziwitso zonse zalembedwa mwa odwala.
4.Neuroimmune System Regulation
Tuftsin ndi chitetezo chamthupi peptide.
Selank imasungabe chidutswa cha tuftsin, motero ali ndi mphamvu, ngakhale wochenjera, immunomodulatory zotsatira.
Neuromodulation ndi mgwirizano wa neuro-immune uwu ndiwowonjezera.
Kafukufuku wopitilira muyeso akuwonetsa kuti Selank ndioyenera kwambiri kusinthika kwamaganizidwe ndi thupi.
Mayankho owongolera kapena ocheperako a chitetezo chamthupi amathandizira kuti pakhale zotsatira zomaliza za njirazi.
Umoyo wamaganizo ndi thupi zimadalirana.
5.Kuthekera pochiza vuto la obsessive-compulsive and agitation
Malipoti ena akuwonetsa kuti selank imakhudza kulumikizana pakati pa amygdala ndi prefrontal cortex; kulimbikitsa kutha kwa mantha kukhala chimodzi mwazinthu zomwe zimawoneka bwino kwambiri.
Obsessive-compulsive disorder ndi mitundu yosiyanasiyana yamavuto imagwera m'gulu ili ngati chandamale choyambirira chamankhwala.
Kuyesera kwa zinyama kwawonetsa kuchepa kwakukulu kwa khalidwe lofutukula ubweya wochititsa chidwi, muyeso wovomerezeka wa chipwirikiti chenicheni.
Asayansi ayamba kulingalira njira zomwe zimachititsa izi – Kuwongolera kwa gawo lina la serotonin system kukhala chiphunzitso chotsogolera, kusinthasintha kwa kupsinjika kumakulitsidwa m'maphunziro angapo.
Kafukufuku wokhudzana ndi izi akupitilirabe, koma kufufuza njira zochiritsira zomwe zingatheke ndizofunikira; kuchiza matenda omwe tawatchulawa (misala kapena ayi) ikadali cholinga chachikulu komanso chotheka kutheka.
COA
Mtengo wa HPLC
MS
