सेलांक

सेलांक, possessing the amino acid sequence H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, is a potent and long-lasting anti-anxiety drug.

अपना प्यार बांटें

सेलांक, possessing the amino acid sequence H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, is a potent and long-lasting anti-anxiety drug.

Derived from the retention and subsequent modification of a tuftsin core fragment, this process significantly enhances its ability to cross the रक्त मस्तिष्क अवरोध; unique central nervous system activity is a direct result of said modification.

Since the beginning of this century numerous clinical trials have been performed on Selank; complex pharmacological properties spanning multiple modalities and multiple potential targets have been documented.

A stable mechanism of action is what makes Selank particularly valuable; rebound effects do not occur upon discontinuation.

Neurological diseases benefit from a triple regulatory path: न्यूरोट्रांसमीटर, neuroplasticity and immune system regulation.

अनुक्रम

थ्र-लिस-प्रो-आर्ग-प्रो-ग्लाइ-प्रो

सीएएस संख्या

129954-34-3

आण्विक सूत्र

C33H57N11O9

आणविक वजन

751.887

Research Of Selank

1.क्रिया के तंत्र और चिकित्सीय प्रभाव

Its core function is the regulation of the balance within key neurotransmitter systems in the brain.

Modulating the transmission of γ-aminobutyric acid (गाबा) विशेष रूप से, along with various regulatory effects on serotonin and dopaminergic systems, leads to excellent anti-anxiety and antidepressant effects.

Enhanced hippocampal neuronal plasticity has also been shown; संज्ञानात्मक वृद्धि (learning, memory consolidation, attention being prime examples) is at least partially attributable to this line of regulation.

The retention of the original tuftsin core allows for significant efficacy in regulating the cellular immune status, साइटोकिन्स (interferon being one of the better studied) – an immunomodulatory effect the body can use to cope with various stress.

Clinical studies support the improvement of mood and enhanced psychological resilience that Selank facilitates.

2.Anti-anxiety and antidepressant effects

Unlike traditional anti-anxiety and antidepressant drugs, selank does not act directly on GABA receptors.

बजाय, it works by regulating various key neurotransmitters within the brain.

Experiments have shown that selank enhances the transmission efficiency of this निरोधात्मक न्यूरोट्रांसमीटर, गाबा; inhibiting excessive neuronal activity and subsequently anxiety being the primary outcome of this process.

Further regulation of neurotransmittersdopamine being a prime exampleallows selank to significantly increase the nervous system’s stress resilience.

Mood swings and associated positive/negative feelings of pleasure are at least partially controlled; stable, long term anti-anxiety and antidepressant effects are the result.

Notable side effects (drowsiness, cognitive impairment, addiction being the most well documented) are avoided, making selank a uniquely positioned treatment for certain neurological diseases.

3.Enhancing Cognitive Function and Promoting Neuroplasticity

Selank has demonstrated efficacy in enhancing cognitive function.

Brain Derived Neurotrophic Factor (बीडीएनएफ) is the focus of much of this research; upregulation of its activity is central to neuronal survival, differentiation and all forms of synaptic plasticity.

Hippocampal cells specifically show increased BDNF related activity when treated with selank.

Neural reorganization through new connections has been observedmemory consolidation, learning ability and attention/concentration all improve.

Clearer thinking, faster information processing and positive results in cognitive tests have all been recorded in patients.

4.Neuroimmune System Regulation

Tuftsin is a natural immune peptide.

Selank retains a core fragment of tuftsin, thus possessing a powerful, though subtle, immunomodulatory effect.

Neuromodulation and this neuro-immune interaction are complementary.

Chronic stress studies show Selank to be particularly well suited to psychological and physiological adaptation.

Improved or at least balanced immune responses contribute to the end result of these mechanisms.

Psychological and physical well-being are interdependent.

5.Potential for treating obsessive-compulsive disorder and agitation

Some reports indicate that selank influences the connection between the प्रमस्तिष्कखंड और मस्तिष्काग्र की बाह्य परत; promoting fear extinction being one of the more directly observable effects.

Obsessive-compulsive disorder and various forms of agitation fall under this category as primary targets for treatment.

Animal experiments have shown a significant reduction of agitation-induced fur-puffing behavior, a validated measure of pure agitation.

Scientists have begun to speculate the mechanisms behind thisregulation of at least some aspect of the serotonin system being a leading theory, stress adaptation being enhanced in multiple studies.

Related research is still ongoing, but exploring these potential lines of treatment is important; treating the aforementioned diseases (psychiatric or otherwise) remains a significant and achievable goal.

सीओए

एचपीएलसी

एमएस

(1) हम चाहते हैं, सी. आर।; सफ़ेद, सी. एम. शामक-कृत्रिम निद्रावस्था वाले एजेंट जो गामा-एमिनोब्यूट्रिक एसिड रिसेप्टर्स को प्रभावित करते हैं: फ्लुनिट्राज़ेपम पर ध्यान दें, गामा-हाइड्रॉक्सीब्यूट्रिक एसिड, Phenibut, और सेलांक. जे क्लिन फार्माकोल 2021, 61 आपूर्तिकर्ता 2, S114-S128. डीओआई: 10.1002/jcph.1922 From NLM Medline.

(2) बेकार चीज, एक।; कोलोमिन, टी।; एंड्रिवा, एल; बोंडारेंको, ई.; Myasoedov, एन।; स्लोमिंस्की, पी।; शाद्रिना, एम. पेप्टाइड सेलैंक चूहों में अप्रत्याशित दीर्घकालिक हल्के तनाव की स्थिति में चिंता को कम करने में डायजेपाम के प्रभाव को बढ़ाता है. व्यवहार न्यूरोल 2017, 2017, 5091027. डीओआई: 10.1155/2017/5091027 एनएलएम मेडलाइन से.

(3) नत्थी करना, एल. जी।; नादोरोवा, ए. वी; एंटीपोवा, टी. एक।; क्रूगलोव, एस. वी; कुद्रिन, वी. एस।; डर्नेव, ए. डी. सेलांक, टफ्ट्सिन का पेप्टाइड एनालॉग, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. बुल एक्सप बायोल मेड 2019, 167 (5), 641-644. डीओआई: 10.1007/s10517-019-04588-9 From NLM Medline.

(4) नत्थी करना, एल. जी।; नादोरोवा, ए. वी; सेरेडेनिन, एस. बी. सेलैंक डीबीए/2 चूहों में इथेनॉल-प्रेरित हाइपरलोकोमोशन और व्यवहार संबंधी संवेदनशीलता की अभिव्यक्ति को रोकता है. बुल एक्सप बायोल मेड 2016, 162 (1), 56-59. डीओआई: 10.1007/s10517-016-3544-6 एनएलएम मेडलाइन से.

(5) लागत, एन. वी; सोकोलोव, ओ; गबाएवा, एम. वी; Grivennikov, मैं. एक।; एंड्रिवा, एल. एक।; मियासोएडोव, एन. एफ।; ज़ोज़ुलिया, ए. ए. [सेमैक्स और सेलांक मानव सीरम से एन्केफेलिन-डिग्रेडिंग एंजाइम को रोकते हैं]]. बायोऑर्ग खिम 2001, 27 (3), 180-183. डीओआई: 10.1023/ए:1011373002885 एनएलएम मेडलाइन से.

(6) मुझें नहीं पता, जी. जी।; तेलेशोवा, ई. एस।; बोचकेरेव, वी. के.; कोस्चेलेव, वी. वी; स्यून्याकोव, टी. एस. पी.3.036 उपन्यास चिंताजनक सेलंक: द्वितीय चरण के नैदानिक ​​​​परीक्षणों के परिणाम. यूरोपीय न्यूरोसाइकोफार्माकोलॉजी 2005, 15, S159-S160. डीओआई: 10.1016/s0924-977x(05)80332-3.

(7) स्लोमिंस्की, पी. एक।; शाद्रिना, एम. मैं।; कोलोमिन, टी. एक।; स्टावरोव्स्काया, ए. वी; फिलाटोवा, ई. वी; एंड्रिवा, एल. एक।; इलारियोस्किन, एस. एन।; Myasoedov, एन. एफ. पेप्टाइड्स सेमैक्स और सेलांक 6-ओएचडीए प्रेरित पीडी-जैसे पार्किंसनिज़्म वाले चूहों के व्यवहार को प्रभावित करते हैं. जब तक बायोल विज्ञान 2017, 474 (1), 106-109. डीओआई: 10.1134/S0012496617030048 From NLM Medline.

(8) Sollertinskaja, टी. एन।; Shorokhov, एम. वी; Myasoedov, एन. एफ. विभिन्न प्रकार के न्यूरोसिस पर प्राइमेट्स में सेमैक्स और सेलैंक के मस्तिष्क-सुरक्षात्मक प्रभाव. साइकोफिजियोलॉजी के अंतर्राष्ट्रीय जर्नल 2008, 69 (3). डीओआई: 10.1016/जे.आईजेसाइको.2008.05.356.

(9) Sollertinskaya, टी. एन।; Shorokhov, एम. वी; Kozlovskaya, एम. एम।; Kozlovskii, मैं. मैं।; Sudakov, के. वी. Compensatory and antiamnestic effects of heptapeptide Selank in monkeys. Journal of Evolutionary Biochemistry and Physiology 2008, 44 (3), 332-340. डीओआई: 10.1134/s0022093008030101.

अनुक्रम:

थ्र-लिस-प्रो-आर्ग-प्रो-ग्लाइ-प्रो

कैस:

129954-34-3

M.W:

751.887 जी/मोल

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