Cartalax waa peptide synthetic silsilad gaaban oo leh taxanaha amino acid Ala-Glu-Asp. Ka soo jeeda jajab borotiin dabiici ah oo ku dhex jira carjawda caafimaadka qabta, waa unugyo synthetic ah oo si taxadar leh loo qaabeeyey.
Taxanaha gaarka ah ee asiidhyada amino-ku waxay shabahaan kuwa endogenous molecules calaamadaha; ku xidhan qaar ka mid ah receptors-ka gacanta, jawaabaha gacanta ee soo socda ayaa kiciyay.
Naqshadaynta synthetic ee macquulka ah waxay siisay Cartalax dhaqdhaqaaqa bayoolojiga sare, gaar ahaaneed, difaaca jirka oo hooseeya, iyo nuugista afka ama transdermal wanaagsan.
Cilmi-baadhista socota waxay tafaasiilaysaa bartilmaameedyada badan, awood difaac iyo dib u habeyn heerar badan ah.
Xakamaynta waxtarka leh ee bararka waa mid ka mid ah natiijadaas – hoos u dhigista cytokine pro-bararka soo jiidan Matrix metalloproteinase (MMPs) iyo ADAMTS isagoo ah hababka aasaasiga ah; nabaad-guurka tooska ah iyo hoos u dhaca nooca II collagen iyo kala duwan proteoglycans waa la dhimay, carjawda articular sharafta dhismaha oo la ilaalinayo.
Kobcinta awooda dib u soo kabashada ee matrix ka baxsan unugyada waa qayb kale oo ficil ah oo ay soo jeediyeen daraasado dhowaanahan; chondrocyte calaamado gaar ah ayaa la hagaajiyay oo isku-duubnaantooda ayaa kor loo qaaday.
Burburka carjawda yar waxaa lagu hagaajin karaa hababkan, caafimaad qaba homeostasis lagu hayo.
Anti-bararka, Qalabka difaaca jirka iyo gabowga ka-hortagga ayaa dhammaantood ah qayb ka mid ah astaanta Cartalax; Tijaabooyin caafimaad ayaa hadda sahaminaya dhammaan kuwa kor ku xusan.
Qalabaynta iyo codsiga Cartalax waxay ka dhigan tahay jihada rajo-gelinta leh ee daaweynta peptide-ka bioactive.
Isku xigxiga
Ala-Glu-Asp
Lambarka CAS
/
Qaanuunka molecular
C12H19N3O8
Miisaanka Molecular
333.297
Cilmi-baarista Cartalax Peptide
1.Joojinta carjawda Catabolism
Sida la sheegay, Ka-hortagga nabaad-guurka xad-dhaafka ah waa udub dhexaadka dhammaan cilmi-baarista ku saleysan Cartalax.
Aan caadi ahayn cunsur pro-bararka calaamadaynta waa in la joojiyo, iyo enzymes ka masuulka ah hoos u dhigista matrixka (mar kale, ugu horrayn MMPs/Matrix Metalloproteinase) si toos ah ama si dadban ha loo joojiyo.
Daacadnimada makaanikada ee unugyada carjawda ayaa ah meesha ugu dambeysa ee shaqadan oo dhan.
2.Horumarinta Carjawda Synthesis
Cartalax waxay sidoo kale muujisaa awood gaar ah si kor loogu qaado dheef-shiid kiimikaadka unugyada.
Kor u qaadida chondrocyte hawlkarnimo, waxay si degdeg ah u kordhisaa isku-dhafka iyo dheecaanka xiga ee qaybaha kala duwan ee matrixka ka baxsan; samaynta carjawda tooska ah waa natiijada ugu dambaysa ee habkan.
Daraasadaha in vitro ayaa xaqiijiyay saameyntan – chondrocytes-ka la daweeyay ama unugyada asliga ah waxay muujinayaan heerar muujinta hidde-sidaha oo aad u sarreeya ee nooca II kolajka iyo aggrecan, iyadoo korodhka u dhiganta ee wax soo saarka dhabta ah ee borotiinada la sheegay.
Kordhinta aan tooska ahayn ee dheeraadka ah ee dheef-shiid kiimikaadka gacanta iyo isku-darka borotiinka waxaa lagu gaaraa iyada oo loo marayo dariiqooyin calaamadineed oo gaar ah (TGF-β/Smad oo ah tusaalaha ugu muhiimsan); cusboonaysiinta unuggu waa natiijada la rabo.
Dayactirka yar-yar ee horay u jiray iyo dhisidda matrix shaqaynaysa waa laba dariiqo oo qiimo leh oo ay suurtagelisay xariiqan ficil.
3.Ka-hortagga-bararka iyo Saamaynta Immunomodulatory
NF-κB waxay u adeegtaa sidii calaamad fure u ah kicinta arrimo badan oo barar ah.
Cartalax si firfircoon ayuu u xakameeyaa, ama ugu yaraan ay yareyso, NF-κB muujinta – garaacida isha jawaabaha bararka badankooda.
Xanuun, bararka iyo qallafsanaanta joogtada ah ee la xidhiidha caabuqa dhamaantood si wax ku ool ah ayaa loo yareeyey.
Saamaynta ilaalinta carjawda ee kor lagu sharaxay waa qayb ka mid ah habkan ka hortagga bararka; dhimista bararka waa qayb aasaasi ah oo ka mid ah habka guud ee waxqabadka Cartalax.
COA
HPLC
MS
