ICartalax yi peptide yokwenziwa yetsheyini emfutshane ene-amino acid elandelelanayo iAla-Glu-Asp. Ithathwe kwiqhekeza leprotheyini yendalo ekhoyo ngaphakathi kwe-cartilage ephilileyo, yimolekyuli eyenziwe ngobuchule.
Ulandelelwano oluthile lwee-amino acids lulinganisa ezo ze endogenous iimolekyuli zomqondiso; Ukubophelela kwii-receptors ezithile zeselula, i-cascade elandelayo yeempendulo zeselula iyaqhutywa.
Uyilo oluqiqiweyo lokwenziwa lunika iCartalax umsebenzi ophezulu webhayoloji, iinkcukacha ezithile, i-immunogenicity ephantsi, kunye nokufunxwa kakuhle kwe-transdermal okanye ngomlomo.
Uphando oluqhubekayo lunika iinkcukacha ekujoliswe kuzo ezininzi, Ukhuseleko olubanzi olunamanqanaba amaninzi kunye namandla okubuyisela.
Ukunyanzeliswa okusebenzayo kokuvuvukala sesinye seziphumo ezinjalo – ukuthotywa kwe pro-ukudumba cytokine enziwe Matrix metalloproteinases (Ii-MMPs) kwaye UADAMTS ukuba ziindlela eziphambili; ukukhukuliseka ngokuthe ngqo kunye nokuthotywa kohlobo lwe-collagen ye-II kunye neentlobo ezahlukeneyo iiproteoglycans ziyancitshiswa, i-articular cartilage imfezeko yolwakhiwo iyagcinwa.
Ukuphucula amandla okuhlaziya i-matrix engaphandle ngomnye umgca wesenzo ocetyiswe luphononongo lwamva nje; chondrocyte iimpawu ezithile zilawulwa kwaye ukuhlanganiswa kwazo kukhuthazwa.
Umonakalo omncinci we-cartilage unokulungiswa ngezi ndlela, esempilweni i-homeostasis zigcinwe.
Ukuchasana nokudumba, I-immunomodulatory kunye ne-anti-aging properties zonke ziyinxalenye yeprofayili yeCartalax; ulingo lwezonyango ngoku luphonononga zonke ezi zinto zingasentla.
I-Synthesis kunye nokusetyenziswa kweCartalax imele isikhokelo esithembisayo sonyango lwe-peptide ye-bioactive.
Ulandelelwano
Ala-Glu-Asp
Inombolo yeCAS
/
Ifomula yeemolekyuli
I-C12H19N3O8
Ubunzima beMolekyuli
333.297
Uphando lweCartalax Peptide
1.Ukuthintelwa kweCartilage I-Catabolism
Njengoko kuchaziwe, ukuthintela ukuthotywa okugqithisileyo kungundoqo walo lonke uphando olusekwe kwiCartalax.
Ayiqhelekanga into ebangela ukudumba umqondiso kufuneka uphazamiseke, kunye nee-enzymes ezijongene nokuthotywa kwe-matrix (kwakhona, kuqala IiMMPs/Matrix Metalloproteinases) ithintelwe ngokuthe ngqo okanye ngokungathanga ngqo.
Ukunyaniseka komatshini wezicubu ze-cartilage yindawo yokugqibela yawo wonke lo msebenzi.
2.Ukunyusa Intlala Ukudibanisa
ICartalax ikwabonisa amandla akhethekileyo okuphucula i-tissue anabolic metabolism.
Ukulawula chondrocyte umsebenzi osebenzayo, inyusa ngokukhawuleza i-synthesis kunye nokukhuselwa okulandelayo kwezinto ezahlukeneyo ze-matrix ze-extracellular; ukubunjwa kwe-cartilage ngokuthe ngqo sisiphumo sokuqala sale nkqubo.
Izifundo ze-in vitro ziqinisekisile le mpembelelo – i-chondrocytes ephathwayo okanye iiseli ze-stem zibonisa amanqanaba aphezulu e-gene expression of type II collagen kunye aggrecan, ngokunyuka okuhambelanayo kwimveliso eyiyo yeeproteni ezixeliweyo.
Uphuculo olongezelelweyo olungathanga ngqo lwemetabolism yeselula kunye neprotein synthesis ifezekiswa ngeendlela ezithile zokubonisa i-intracellular. (TGF-β/Smad ukuba ngumzekelo obalaseleyo); ukuvuselelwa kwezicubu sisiphumo esifunwayo.
Ukulungisa i-microdamage esele ikhona kunye nokwakha i-matrix esebenzayo ziindlela ezimbini ezixabisekileyo ezenziwe ngulo mgca wesenzo..
3.I-Anti-inflammatory kunye ne-Immunomodulatory Effects
NF-kB isebenza njengophawu oluphambili lokuvula izinto ezininzi ezivuthayo.
ICartalax icinezela ngokusebenzayo, okanye ubuncinane kunciphisa, NF-κB intetho – ukubetha umthombo weempendulo ezininzi ezivuthayo.
Iintlungu, ukudumba kunye nokuqina okusisigxina okuhambelana nokudumba konke kuncitshiswe ngempumelelo.
Imiphumo yokukhusela i-cartilage echazwe ngasentla iyingxenye yangaphakathi yale nkqubo yokuchasana nokuvuvukala; ukunciphisa ukuvuvukala ngumba osisiseko weCartalax yendlela yokusebenza.
I-COA
HPLC
NKSK
