LL-37

LL-37 yi i-antimicrobial peptide isuka e cathelicidin usapho. Igama ngokwalo libhekisa kuyo 37 ukwakheka kwe-amino acid kunye nokuqaliswa kwe-N-terminal ezimbini leucine iintsalela. HCAP18, ekuphela kwelungu losapho lwe-cathelicidin yomntu, Icandeke ngokukodwa ziiproteases zabantu ukukhulula eliqhekeza lebhayoloji leLL-37.

Ukufunyanwa kwe-LL-37 kuphawule utshintsho olusesikweni lophando lwe-cathelicidin ukusuka kwimodeli yezilwanyana ukuya ebantwini.. Njengenxalenye ebalulekileyo yesistim somzimba sokuzalwa, I-LL-37 idlala indima ebalulekileyo ekukhuseleni komntu kwii-pathogens.

Umsebenzi ophambili wolu khuselo ngumsebenzi othe ngqo we-antibacterial spectrum. I-amphipathic α-helical(Alpha helix) Ulwakhiwo olunoxanduva lwalo msebenzi lubangela umtsalane we-electrostatic ukuya kwiinwebu zebhaktiriya ezihlawuliswa kakubi. Ukuphazamiseka ngokuthe ngqo kwengqibelelo ye-membrane kukhokelela ekulahlekelweni kwezondlo ze-intracellular; Ukufa okupheleleyo kwebhaktheriya kulandela. Ngokucacileyo, lo matshini awubangeli naluphi na uhlobo lokuchasa.

Eminye imisebenzi ngaphakathi emzimbeni ikwabalelwa kuyo – ukuphiliswa kwenxeba, ukulungiswa kwezicubu, i-immunomodulation enamandla, endotoxin ukungathathi hlangothi, kwaye ibonise i-anti-cancer kunye ne-anti-viral effects.

Ulandelelwano

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Glu-AV-Asn

Inombolo yeCAS

154947-66-7

Ifomula yeemolekyuli

C205H340N60O53

Ubunzima beMolekyuli

4493.34

LL-37 Uphando olunxulumeneyo

1.I-Broad-Spectrum Direct Antibacterial Activity

Isenzo esikhawulezayo nesithe ngqo se-bactericidal ngokuchasene neendidi ezininzi microorganisms ngowona msebenzi ubhalwe kakuhle weLL-37. I-Gram negative, elungileyo, kunye nokungunda iintsholongwane bonke babulawa ngempumelelo.

I-cationic, Iimpawu ze-amphipathic zepeptide zingundoqo kule nkqubo; amacandelo ahlawuliweyo abopha ngokuthe ngqo kwiinwebu zebhaktheriya. Ukuvuza komxholo weselula kunye nokuwa kwe-membrane enokubakho ziziphumo zokugqibela zohlaselo.

Amayeza okubulala iintsholongwane esintu asebenza ngeendlela ezahlukeneyo (kwaye rhoqo kujoliswe ngokuthe ngqo) iindlela zokuxhathisa; Indlela yokuhlaselwa kwe-LL-37 ikhawuleza kwaye, ukuya kumhla, ayidityaniswanga nophuhliso olubonakalayo lokuchasa. Izifundo zeklinikhi zabantu zixhasa ukhuseleko kunye nokusebenza kakuhle kwe-LL-37 njenge-arhente yonyango.

2.Umsebenzi onamandla we-Immunomodulatory

I-LL-37 yenza iziphumo zayo ngokusekelwe kwi-microenvironment yendawo ngaphakathi komzimba. Ekubonweni kokulimala kwezicubu okanye utshintsho lwe-pathological, I-LL-37 ivula izinto ezahlukeneyo zolawulo kunye neeseli ukuba zihlangane kwezi ndawo.

Ukumodareyithwa kokukhutshwa kwe-cytokine evuthayo yenye yeendlela zayo eziphambili; iimpendulo ezigqithisileyo ezixhasa ukudumba zithotywa ngokukodwa. Ukunyusa iseli dendritic(DC) ukuvuthwa kunye nokulandelayo T iseli Umahluko ngomnye umba ophambili wale nkqubo – emele ibhulorho ebalulekileyo phakathi kokhuselo oluzalwa kunye noluguquguqukayo.

3.Ukukhuthaza ukuPhiliswa kwenxeba kunye nokulungiswa kweTissue

I-LL-37 yokuphulukisa isilonda kunye namandla okulungisa izicubu zidibene ngokuthe ngqo kwimisebenzi yayo ye-immunomodulatory, kunye nomsebenzi othe ngqo we-antimicrobial.

Ukusetyenziswa kweendlela zokulwa ne-antimicrobial kubangela iikeratinocytes, iifibroblasts, kunye neeseli ze-endothelial ukuba zifudukele kwindawo yenxeba; ukwanda kweeseli kulandela njengoko umonakalo ulungiswa. I-Angiogenesis ibonelela ngamandla kunye nokuhanjiswa kwezondlo kwizicubu ezonzakeleyo.

4.Anti-umhlaza Umsebenzi

Iiseli zomhlaza ngokubanzi zabelana ngophawu oluqhelekileyo lokubhentsisa icala elibi phosphatidylserine kwiinwebu zabo zangaphandle (iiseli eziqhelekileyo ezinendawo yangaphakathi kwezi phospholipids). Intlawulo elungileyo ye-LL-37 iyatsalwa kubo.

I-apoptosis kunye ne-necrotic iindlela zokufa ezifanayo nezo zisetyenziswa ngokuchasene neebhaktheriya ziyaqaliswa. Ngokungathanga ngqo anti-ithumba iziphumo ngokumodareyitha amajoni omzimba nazo zidlala indima.

Uphononongo lwangaphambi kweklinikhi lubonise ukuncipha okucacileyo kwiiseli zomhlaza eziphathwe nge-LL-37; unyango lwe-anticancer usebenzisa i-LL-37 yindawo ethembisayo yophando.

I-COA

HPLC

NKSK

(1) Chromek, M.; Slamova, Z.; Bergman, P.; Umkhandi weentsimbi, L.; IPodracka, L. u.; Ehrén, I.; Hökfelt, T.; Gudmundsson, G. H.; Gallo, R. L.; Agerberth, B.; okqhubekayo. I-antimicrobial peptide cathelicidin ikhusela umjelo womchamo kusulelo lwebhaktiriya ehlaselayo.. Unyango Lwendalo 2006, 12 (6), 636-641. DOI: 10.1038/nm1407.

(2) Umlandeli, D.; Coughlin, L. A.; Neubauer, M. M.; UKim, J.; UKim, M. S.; Zhan, X.; Simms-Waldrip, T. R.; Xie, Y.; Hooper, L. V.; Koh, A. Y. Ukusebenza kwe-HIF-1α kunye ne-LL-37 yi-bacteria ye-commensal inqanda i-Candida albicans colonization. Unyango Lwendalo 2015, 21 (7), 808-814. DOI: 10.1038/nm.3871.

(3) Chen, X.; Deng, S.; Wang, W.; Castiglione, S.; Duan, Z.; IsiLuo, L.; Cianci, F.; Zhang, X.; Xu, J.; Li, H.; okqhubekayo. I-peptide ye-antimicrobial yabantu i-LL-37 inegalelo ekuqhubekeni kwesifo se-Alzheimer. I-Molecular Psychiatry 2022, 27 (11), 4790-4799. DOI: 10.1038/s41380-022-01790-6.

(4) Yiyiphi, X.; Guo, J.-L.; Yena, J.; Kwaye, R.-J.; Liu, P.-P.; Zhang, Z.-R.; Wang, A.-M.; Zhang, J. I-Chitosan hydrogel efakwe kwi-LL-37 peptide ikhuthaza ukuphiliswa kokulimala kwezicubu kwimodeli yempuku.. Uphando lwezoNyango lomkhosi 2020, 7 (1). DOI: 10.1186/s40779-020-00249-5.

(5) Zhou, Q.; Ipani, L.-L.; Xue, R.; Kwi, G.; Duan, Y.; Bhayi, Y.; Shi, C.; Ren, Z.; Wu, C.; Li, G.; okqhubekayo. Amanqanaba e-anti-microbial peptide LL-37/CRAMP anxulunyaniswa nokungaphumeleli kwentliziyo kwaye anokunciphisa ukungasebenzi kakuhle kwentliziyo kwiimodeli ezininzi zangaphambili zokungaphumeleli kwentliziyo.. ITheranostics 2020, 10 (14), 6167-6181. DOI: 10.7150/Hayi. 46225.

(6) Ren, S. X.; Cheng, A. S. L.; Ukuya, K. F.; Tong, J. H. M.; Li, M. S.; Shen, J.; Wong, C. C. M.; Zhang, L.; Chan, R. L. Y.; Wang, X. J.; okqhubekayo. I-Peptide yoKhuseleko lwe-Immune ye-L-37 yenza i-Caspase-Independent Apoptosis kwaye icinezela uMhlaza weColon. Uphando lomhlaza 2012, 72 (24), 6512-6523. DOI: 10.1158/0008-5472.Ngaba-12-2359.

iinkcukacha	10mg, 2mg

Iimveliso

Iindaba

LL-37