KPV peptide yog dab tsi：KPV yog ib qho hluavtaws bioactive peptide muab los ntawm C-terminal ultra-luv tripeptide fragment ntawm ib txwm tshwm sim. α-Melanocyte-Stimulating Hormone (α-MSH). Kev tshawb fawb rau ntau yam α-MSH fragments coj cov kws tshawb fawb los tshawb pom tias qhov tshwj xeeb C-terminal sequence KPV – suav nrog peb cov amino acids kawg – poob nws cov melanogenesis txhawb cov nyhuv; Nws muaj txiaj ntsig zoo rau kev tiv thaiv kab mob thiab immunomodulatory zog, txawm li cas los xij, khaws cia.
KPV nws tus kheej ua los ntawm cov txheej txheem tsis-ergoline; inhibition ntawm kev ua kom thiab kev hloov pauv tom qab ntawm qhov tseem ceeb inflammatory yam tseem ceeb yog thawj hom kev ua. Ntau yam pro-inflammatory cytokines yog li no zoo suppressed nyob rau hauv ob qho tib si ntau lawm thiab tso tawm.
Kev hloov pauv ntawm cov kab mob tiv thaiv kab mob tshwj xeeb (lymphocytes, macrophages ntawm lwm tus) yog lwm qhov tseem ceeb ntawm nws cov nyhuv, reshaping lub cev sab hauv los tiv thaiv ib puag ncig. Inflammatory kho yog stimulated thiab tag nrho cov anti-inflammatory kev ua yog nce.
Cov kev sim tshuaj ntsuam xyuas tau pom tias muaj kev txhim kho meej hauv sim colitis; txo mucosal edema, kev tiv thaiv ntawm plab hnyuv barrier muaj nuj nqi, thiab ntau hom kev kho cov ntaub so ntswg / cell theem yog txhua yam ntsuas tau.
Qhov qis molecular hnyav ntawm KPV yog lwm qhov zoo dua, conferring zoo heev ntawm qhov ncauj bioavailability thiab tseem ceeb transdermal absorption muaj peev xwm. Kev tswj qhov ncauj tso cai rau nws tiv thaiv kev degradation los ntawm txoj hnyuv cov enzymes thiab ncav cuag txoj hnyuv mucosal tiv thaiv kab mob ncaj qha.
Ib ntus
H-Lys-Pro-Val-OH
CAS Nr
67727-97-3
Molecular Formula
C16H30N4O4
Molecular Luj
342.44
Kev tshawb fawb ntawm KPV Peptide
1.Anti-inflammatory Function
Qhov no yog lub hauv paus, Lub luag haujlwm tseem ceeb ntawm KPV. Targeting qhov tseem ceeb NF- IB nyob rau hauv cellular inflammatory signaling pathways, thaiv cov txheej txheem ua kom / hloov chaw yog qhov txhais tau tias nws ua.
Kev nthuav qhia thiab kev sau ntawv ntawm cov kws kho mob pro-inflammatory yog cuam tshuam ntawm qhov chaw. Anti-inflammatory yam tseem ceeb kuj txhawb.
Hloov cov cellular inflammatory ib puag ncig yog ib qho tseem ceeb kawg-point ntawm KPV ob txoj cai tswj kev ua.
2.Immunomodulatory teebmeem
KPV's immunoregulatory muaj nuj nqi yog los ntawm nws lub zog tiv thaiv kab mob. Tshem tawm cov kev qhia ntawm pro-inflammatory M1 noob, Qhov kev ua haujlwm no ua rau muaj kev nrawm nrawm rau kev kho M2 phenotype polarization – ib tug tseem ceeb tswj mechanism nyob rau hauv lub cev tiv thaiv kab mob.
Kev tswj hwm tas li ntawm KPV rau cov nas uas pom cov kab mob inflammatory tshwm sim hauv pab pawg sim uas qhia tias txo qhov mob., los yog ua kom tiav kev daws teeb meem ntawm no; physiological functions aligning ze nrog kev noj qab haus huv tswj.
3.Kev tiv thaiv tshwj xeeb rau kab mob plab hnyuv (IBD)
Exceptional daim ntawv thov nqi yog tso tawm los ntawm KPV nyob rau hauv txoj hnyuv.
Nas qauv ntawm o qhia meej kev txhim kho ntawm IBD(Kab mob plab hnyuv) cov tsos mob los ntawm kev tswj qhov ncauj. Cov kab mob plab hnyuv puas, edema, kev yaig, thiab inflammatory cell infiltration yog tag nrho cov ho txo.
Kev kho thiab ntxiv dag zog rau kev ncaj ncees ntawm cov mucosal barrier yog ib qho ntawm KPV cov haujlwm tseem ceeb; txo plab hnyuv permeability raws li nram no. Cov kab mob thiab lawv cov antigens raug tiv thaiv los ntawm translocating hla txoj hnyuv, yog li tiv thaiv overactivation ntawm lub cev tsis muaj zog ntawm nws cov hauv paus hauv paus.
Kho ntawm mucosa nws tus kheej yog ib qho kev tshwm sim ncaj qha ntawm cov kev tiv thaiv no.
4.Txhawb nqa cov ntaub so ntswg kho thiab rov tsim dua tshiab
Los ntawm suppressing o, KPV tsim kev txhim kho cellular microenvironment rau kev kho kom zoo li no.
Anti-inflammatory thiab cellular kho yam yog qhib. Cov kev tshawb fawb tau pom tias kev kho kom nrawm dua thiab rov tsim dua tshiab ntawm cov kab mob hauv plab hnyuv epithelial thiab daim tawv nqaij epidermal hlwb hauv KPV-kho kev kawm.
Kev kho mob, thiab txhua yam ua raws li, yog ib feem ntawm qhov KPV muaj peev xwm ua tiav.
COA
HPLC
MS
