Acetyl hexapeptide 1 (ingoa hokohoko Melitane) he peptide koiora waihanga.
He nui nga rangahau kua mahia mo tenei whakauru, me tana tono i roto i te mara whakapaipai kua tino tuhia.
Tona multifunctional anti-wrinkle, whakatikatika, me nga taonga tiaki kiri e tino mohiotia ana.
Raupapa
Ac-{Ka taea}-Ala-Tana-{d-Phe}-Arg-Trp-NH2
Tau CAS
448944-47-6
Tātai rāpoi
C43H59N13O7
Taumaha rāpoi
870.01 g/mol
Rangahau o Acetyl Hexapeptide 1
Acetyl hexapeptide 1 he maha nga mahi koiora maha; ko nga paanga e tino mohiohia ana ka tutuki ma roto i nga huarahi ngota e rua.
Ko te whawhai i nga kita me nga ture whakangao he tauira nui o enei kaha.
Ko te tino whai huatanga e mohiotia ana – anti-wrinkle te mea tuatahi – ka whai i nga rarangi korero (korikori hihiri motuhake).
He rite ki te Acetyl Hexapeptide-8 (Argireline), ko tenei tikanga mahi te mea e whakaatu ana i tana whakamahinga.
The core anti-wrinkle process involves interfering with signal transmission at a neuromuscular junction.
Studies show simultaneous presynaptic and postsynaptic interactions.
Presynaptically, competitive binding to Munc-18 protein prevents full Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor (SNARE) complex assembly, reduced acetylcholine release being the direct outcome.
Weakening the contraction signal received by the muscle itself leads to muscle relaxation.
Postsynaptically, Acetylcholine (ACh) receptor activation is inhibited, calcium influx is curtailed, muscle contraction lessened and thus dynamic wrinkles diminished.
Inhibitory efficiencies of up to 37% (SNARE related) a 29% acetylcholine release point to a clear potency advantage over Argireline.
A second, but equally important, key role of Acetyl Hexapeptide 1 is its agonist activity toward α-MSH.
Ko te α-MSH taiao he homoni mutunga; here ki Melanocortin 1 kaiwhakawhiwhi (MC1R) Ko nga kaiwhakawhiwhi melanocyte ka timata i te riipene tohu tohu e pa ana ki te pigment.
Acetyl hexapeptide 1 ka peehia tenei mahi.
Te tiaki i te tae o nga makawe me te whakaroa o te hina, na roto i te whakaongaonga o nga melanocytes, Ko tetahi o nga tono nui ake mo te hokohoko o tenei rarangi rangahau.
A 2023 I arotakehia e te rangahau te kaha o te serum kei roto te retinol supramolecular me te Acetyl hexapeptide. 1 i roto i te whakapai ake i te kiri kanohi whakaahua ngawari.
E toru tekau ma rua nga wahine Hainamana waenga-pakeke i uru ki te ako; ko te waahi maimoatanga 8-wiki te kaupapa o te rangahau.
Te whakapai ake i nga ahuatanga rereke o nga kaupapa’ i kitea te ahua o te kiri.
I tenei wa, Acetyl hexapeptide 1 kua whakauruhia ki roto i nga hua anti-pakeke utu nui – Ko nga serum te ahua tino noa, me nga kirimini me nga hua kanohi motuhake e whai ake nei.
Nga kai neuromodulatory tuku iho (Ko te paitini botulinum te tauira nui) kua whakatakotohia te paerewa mo te ahua o te mahi whakakeke; tono kore-kino, haumaru teitei, me te tolerability pai hanga Acetyl hexapeptide 1 he pai mo te whakamahi i ia ra mo te wa roa mo te tiaki kiri.
COA
HPLC
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