Te whakarite me te arotake koiora tuatahi o n-Gluc-Lys([Al18 F]WHAKAMAHI)-TOCA

Ka taea e te Octreotide me o raatau hua te herea ki te kaiawhina somatostatin (SSTR) i te nuinga o te wa ka nui te whakahua i runga i te maha o nga pūtau puku. Na ko te 18F kua tapaina he octreotide me o raatau huanga ka taea te whakamahi mo te tātari me te arotake i te whaihua rongoa o nga pukupuku pai SSTR. Hei tirotiro i tetahi rangahau PET hou mo te mate pukupuku SSTR pai, te n-Gluc-Lys([Al18F]WHAKAMAHI)-Ko te TOCA i whakahiatohia i runga i te reo irirangi tere me te whai hua ma te whakamahi i te tauhohenga chelation o n-Gluc-Lys(WHAKAMAHI)-TOCA me Al18F moiety, n-Gluc-Lys([Al18F]WHAKAMAHI)-Ko TOCA he pärönaki octreotide glycosylated i honoa ki 1, 4, 7-triazacyclononane-1, 4, 7-waikawa triacetic(WHAKAMAHI). Ko te pai o te tapanga o n-Gluc-Lys([Al18F]WHAKAMAHI)-Ko TOCA 69% me te tapeke wa whakahiato he 25-30 min. Kua mutu te purema irirangi 95% i muri i te purenga pou HLB. He pai te pumau i roto i te vitro, a he tiketike te hydrophilicity (lg P = -4.20 ± 0.09(n = 3)). Ko nga rangahau tohatoha koiora i nga kiore noa i 2 h i muri i te werohanga e whakaatu ana ko te tangohanga o n-Gluc-Lys([Al18F]WHAKAMAHI)-He tiketike te TOCA i roto i nga whatukuhu ((13.83 ± 3.52)% ID/g(n = 5)) a ka iti te horonga i roto i te ate me te wheua. He nui te whakauru o te samatostatin pancreas receptor express, a he iti te papamuri o te toto me te uaua. Ko enei hua tuatahi e whakarato ana i etahi kaupapa whakamatautau mo te rangahau ano mo te Al18F matatini kua tapaina he octreotide me o raatau taapiri hei tirotiro puku mo te tirotiro i nga pukupuku SSTR-positire.. (kaituhi)