Hexapeptide-1 waa peptide silsilad gaaban oo synthetic ah oo loogu talagalay hagaajinta qaab dhismeedka xudunta u ah jajabka endogenous α-melanocyte-kicinta hormoonka (α-MSH).
Waxay ilaalisaa dhaqdhaqaaqa bayooloji ee α-MSH, laakiin waxay kordhisaa xasiloonideeda iyo receptor doorashada oo leh beddelaadyo amino acid (tusaale, ku beddelashada methionine ee Nle iyo soo bandhigida qaabaynta D ee booska Phe).
Isku xigxiga
Nle-Ala-His-DPhe-Arg-Trp-NH2
Lambarka CAS
/
Qaanuunka molecular
C41H57N13O6
Miisaanka Molecular
828.0
Hexapeptide-1 Cilmi-baaris La Xiriira
α-MSH waa peptide sharciyeysan oo muhiim ah gudaha vivo, iyo taxanaha firfircoon ee ugu yar ee "His-Phe-Arg-Trp" ee looga baahan yahay hawlgelinta melanocortin reseptors (MCRs) ayaa la qeexay 1.
Hexapeptide-1 waa kordhinta taxanaha asaasiga ah ee kore kaas oo Nle iyo Ala lagu daro NH(₂)-terminus, taasoo keentay qaab-dhismeedka hexapeptide ee soo socda: Nle-Ala-His-DPhe-Arg-Trp-NH₂.
Naqshadani kaliya kuma hayso taxanaha calaamadaha muhiimka ah laakiin sidoo kale way kordhisaa nacab nacayb oo leh Nle oo ay kor u qaaddo xasilloonida enzymatic by D-Phe, sidaas awgeed waxay muujinaysaa waxqabad la xoojiyay iyo nolol badhkeed oo dheer labadaba gudaha vitro iyo in vivo marka la barbar dhigo jajabka asalka ah.
Natiijo ahaan, Hexapeptide-1 waa molecule aaladda lagama maarmaanka u ah baaritaanka shaqada MCR iyo tilmaamayaasha daweynta ee la xiriira..
Hexapeptide-1 waxay inta badan u shaqeysaa qoyska melanocortin reseptors (MC1R, MC3R, MC4R, MC5R).
Kuwaas oo ka mid ah, MC1R waxaa si aad ah loogu muujiyey melanocytes maqaarka, keratinocytes iyo unugyada difaaca jirka waana soo-dhoweeyaha dhexe ee xakameynaya midabka maqaarka, caabuq iyo caqabad.
(1).xakameynta wax soo saarka Melanin
Sida agonist MC1R, Hexapeptide-1 waxay ku xidhan tahay MC1R si ay u dhaqaajiso wareegga adenylate-cAMP-Jidka calaamadaynta PKA.
Tani waxay iyaduna kordhinaysaa dhaqdhaqaaqa tyrosinase, taaso soo dedejisa isku dhafka iyo gaadiidka melanin.
Habkan laba-geesoodka ah ayaa awood u siinaya codsigiisa laba ujeedo oo qurxiyo oo muuqda oo iska soo horjeeda: Iftiinka maqaarka iyo harag macmal ah.
Goobaha midabaynta midabaynta kaliya, waxaa loo isticmaali karaa in lagu yareeyo khatarta dhibcaha, marka lagu daro walxaha kale ee iftiiminta ee xooga gaarka ah (arbutin iyo vitamin c).
Isticmaal dhexdhexaad ah, dhanka kale, waxay kaa caawinaysaa in aad yeelato muuqaal qurux badan oo qorraxdu dhunkanayso inta lagu guda jiro madaw.
(2)Wax-ka-beddelka ka-hortagga bararka iyo difaaca
Dhaqdhaqaaqa MC1R ayaa sidoo kale xannibaya NF-κB Dariiqyada calaamadaha caabuqa ee la xidhiidha kuwaas oo, markeeda, waxay hoos u dhigtaa wax soo saarka arrimaha caabuqa (tusaale., TNF-a, IL-6) si loo hagaajiyo casaanka iyo xanaaqa ay keento UV ama cuncun kiimikaad ee maqaarka.
Intaa waxaa dheer, Hexapeptide-1 waxay hagaajisaa shaqada unugyada difaaca jirka ee ku nool maqaarka si ay uga caawiso soo celinta caqabadaha maqaarka ee dhaawacan..
Sidaa darteed waxay ku habboon tahay maqaarka xasaasiga ah iyo alaabta dayactirka habraaca dambe.
(3).Soo kabashada iyo Laalaab La-dagaallanka
Hexapeptide-1 ayaa la muujiyay inuu kor u kaco E-cadherin muujinta cilmi-baaristii ugu dambeysay, kaas oo kor u qaada adhesion u dhexeeya keratinocytes, waxayna dadajisaa soo kabashada maqaarka.
Isla markaana, waxa kale oo ay hawlgelisaa fibroblasts si aan toos ahayn iyada oo loo marayo dariiqa calaamadaynta cAMP si loo kiciyo kolajka iyo jiilka elastin.
Tani waxay kor u qaadaysaa barti maqaarka waxayna yaraynaysaa khadadka fiican, sagging si loo gaaro saameyn kale oo ka hortagga gabowga.
Hexapeptide-1 waa isku-dhafka bayoolajiga qaab-dhismeedka iyo maqaarka ee shaqada.
By the rational modification of the core sequence of natural α-MSH, this short peptide with brightening, anti-inflammation repair and anti-aging multifunctions.
Its discovery provides an alternative to the cosmetic ingredients currently available and introduces new strategies for treatment of pigmentary disorders, sawirid, and skin sensitivity.
COA
HPLC
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