Πεπτίδιο CRO

Provide peptide technology exploration for pharmaceutical and biotechnology companies or research institutions; process development services.

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Peptide CRO Advantage

Τάξη 100 sterile laboratory

Organic Chemistry Specialist

Available in mg-kg grade

Purity from crude to 99%

Multi-modal study routes

Peptide CRO Core Services

Technology development; process mapping.

Design and Synthesis

Customized peptide synthesis

Synthesize peptides of specific sequences (π.χ. γραμμικά πεπτίδια, κυκλικά πεπτίδια, modified peptides, και τα λοιπά.) according to customer requirements.

Τύποι τροποποίησης

φωσφορυλίωση, ακετυλίωση, biotin labeling, φθορίζουσα επισήμανση (FITC, Cy series), ΡΕΓυλίωση, και τα λοιπά.

Special structural peptides

disulfide-bonded cyclic peptides, multimeric peptides, membrane-penetrating peptides (CPP), glycosylated peptides, και τα λοιπά.

Peptide library construction

Provide combinatorial peptide libraries (π.χ. phage display libraries, solid phase synthesis libraries) for high throughput screening.

Process Development

Route design

Chemical synthesis method (solid phase synthesis SPPS, liquid phase synthesis): for short peptides (usually ≤50 αμινοξέα), need to select protection group strategy, αντιδραστήρια σύζευξης, και τα λοιπά.

Biosynthesis (recombinant DNA technology): expression of long peptides or complex modified peptides by microorganisms or cells, requires optimization of host selection (π.χ. μι. coli, yeast) and culture conditions..

Process optimization

Synthesis/expression optimization: increase yield (π.χ. θερμοκρασία, pH, catalyst concentration).

Purification process: chromatography (reversed-phase HPLC, ion exchange) is key, need to optimize elution conditions.

Impurity control: remove missing peptides, mismatched sequences, προϊόντα οξείδωσης, και τα λοιπά. to ensure purity (usually >98%).

Προϊόντα

Νέα