Testagen wani nau'in peptide na roba ne mai yawa wanda aka samo shi daga bincike na tsaka-tsaki a cikin peptide therapeutics da tsarin endocrine..
gyare-gyaren biomimetic dangane da peptides na halitta, haɗe tare da kwamfyutan kwamfyutan kwaikwayo, An yi amfani da su don haɓaka kwanciyar hankali da kuma bioavailability; Immunogenicity daga baya an rage.
Nazarin farko ya nuna cewa Testagen yana tasiri hypothalamic-pituitary-gonadal axis, daidaitawa testosterone sirrin musamman.
Kunnawa na AMPK da iri-iri sirtuin siginar hanyoyi ya biyo baya, inganta fatty acid oxidation da kuma ɗaukar glucose – tarin kitse na visceral da cikakken bayanan martabar lipid kamar yadda aka lura da mahimman abubuwan ingantawa.
Gwaji, a takaice, maganin peptide na roba ne na gaskiya da yawa; Cututtukan da ke da alaƙa da rayuwa suna kusa da kai ga cikakken bayanin aikin sa.
Jeri
H-Lys-Glu-Asp-Gly-OH
Lambar CAS
1026993-38-3
Tsarin kwayoyin halitta
Saukewa: C17H29N5O9
Nauyin Kwayoyin Halitta
447.445
Binciken Testagen Peptide
1.Tasirin Metabolic da Neurological
Shaidar gwaji ta ƙasa LDL cholesterol kuma triglycerides yana nan; nau'in 2 maganin ciwon sukari shine aikace-aikacen da zai yuwu.
Nazarin baya-bayan nan sun nuna gagarumin yuwuwar antioxidant (a tsakanin sauran illolin), ingantawa superoxide dismutase kuma glutathione peroxidase aiki, rage kowane nau'i na necrosis cell oxidative a matsayin makasudin wannan layin bincike.
Musamman bincike ya nuna an inganta mitochondrial aiki.
Ketare shingen kwakwalwar jini, Gwaji yana motsa jiki Neurotrophic factor na kwakwalwa da aka samu (BDNF) asiri; Ayyukan fahimi da kuma rayuwar neuronal duka suna da tasiri sosai.
2.Endocrine Enhancement
Modulation na siginar da aka ambata shine babban abin da aka fi mayar da hankali.
Kai tsaye, daidai tsari na tsarin endocrine a matakin sigina shine abin da ya sa Testagen ya zama sananne.
Kwaikwayi sakin hormone mai sakin gonadotropin(GnRH) a cikin hypothalamus, ingantawa na pituitary secretion (na akalla luteinizing hormone / LH) an samu.
Bayyanar m lokaci sunadaran (alaka da steroidogenesis a cikin kwayoyin jini) Hakanan za'a iya daidaita shi, samar da makamashi na mitochondrial a matsayin na biyu amma mahimmancin ƙarshen ƙarshen.
Rage zumunci’ na jima'i hormone-daure globulin (SHBG) don testosterone wata hanya ce ta Testagen don cimma canjin endocrin.
Duk waɗannan sun haɗu, mafi aminci (zuwa ilimin halin yanzu) Jiyya na tushen endocrine ko aƙalla ɓangarorinsa, su ne kuma koyaushe za su kasance wani ɓangare na alkawarin warkewa na Testagen.
3.Dokokin Makamashi
Testagen yana kunna aikin Hanyar kinase protein mai kunna AMP ko AMPK, wani nau'i na salon salula 'maɓallin wutar lantarki'.
Yin kwaikwayon wannan sigina, yana inganta oxidation fatty acid a cikin hanta da kyallen takarda, hana nau'ikan haɗin lipid iri-iri.
Murkushe triglycerides da ƙananan ƙarancin lipoproteins shine sakamakon kai tsaye na wannan aikin.
Haɓaka ji na insulin wani babban tasiri ne; An inganta amfani da makamashi na musamman da nama da gabobin, jurewar insulin kamar yadda aka rage sosai – visceral farin kit tara a matsayin daya daga cikin mafi auna karshen maki na wannan tsari.
Cikakken tsarin makamashi shine abin da ke magance kiba da kyau da duk abubuwan rashin daidaituwa na glucose na jini wanda ke haifar da abinci mai mai yawa.; yuwuwar ƙimar warkewa don nau'in 2 ciwon sukari yana da kyau rubuce.
4.Abubuwan Antioxidant
Nazarin ya nuna Testagen yana haɓaka ayyukan aƙalla wasu enzymes masu alaƙa da antioxidant (catalase, glutathione peroxidase a matsayin wakili), tura iyakar babba na tsarin kariya na antioxidant na jiki.
Ana haɓaka ƙarfin rigakafi na asali, m lalacewa da oxidative ga duka Kwayoyin da (zuwa babba) DNA yana faruwa.
Binciken anti-tsufa ya nuna musamman raguwa a cikin raguwar mitochondrial, telomere attrition da duk ƙananan abubuwan da suka dace na rayuwa ta salula – m ka'idar tushe ga kowane anti-tsufa aikace-aikace.
Tasirin Ƙwarewar Neuroprotective da Fahimtar Haɓaka: Testagen shine peptide da aka ƙera a hankali don ketare shingen kwakwalwar jini.
Modulating NMDA mai karɓa Aikin shine farkon aikin neuroprotective da aka yi niyya.
Kwakwalwar da aka samu neurotrophic factor (BDNF) kira da kuma alaƙa tafiyar matakai – tsira, banbance-banbance da ci gaban neurons sosai – ana kuma kara kuzari.
Neurogenesis a cikin hippocampus, ƙarfafa ƙwaƙwalwar ajiya da duk abubuwan da ke da alaƙa suna inganta.
Ragewa β-amyloid nau'in guba da asarar dopaminergic neurons (kuma duk bayan ‘mutuwa baya’ na kwakwalwa) ya ƙunshi ƙarshen ƙarshen binciken neurodegenerative.
COA
HPLC
MS
