Sabbin Hazaka a cikin Zane na Bioactive Peptides da Chelating Agents don Hoto da Farfaji a cikin Oncology

Yawancin peptides na roba an ƙera su don ganewar asali da kuma maganin cututtukan daji na ɗan adam dangane da ikon su na kai hari kan takamaiman masu karɓa akan farfajiyar tantanin halitta ko don shiga cikin tantanin halitta.. gyare-gyaren sinadarai na sarƙoƙin amino acid sun inganta aikin nazarin halittu sosai, kwanciyar hankali da ingancin analogues peptide a halin yanzu ana aiki azaman magungunan anticancer ko azaman masu gano hoto na ƙwayoyin cuta.. Zaman lafiyar somatostatin, Integrins da analogues na bombesin a cikin jikin ɗan adam sun ƙaru sosai ta hanyar hawan keke da/ko shigar da amino acid waɗanda ba na halitta ba a cikin jerin peptide.. Haka kuma, Gabaɗaya pharmacokinetic Properties na irin wannan analogues da sauransu (ciki har da cholecystokinin, peptide na intestinal vasoactive da neurotensin analogues) An inganta su ta hanyar PEGylation da glycosylation. Bugu da kari, haɗuwa da waɗannan analogues na peptide zuwa sabbin masu haɗin gwiwa da chelators bifunctional (kamar AAZTA, AUNT, TARKO, NUMBER da dai sauransu.), samar da radiyo mai lakabin radiyo tare da ƙãra rabin rayuwa da kuma ɗaure mafi girma ga masu karɓa na cognate. Wannan bita ya bayyana mafi mahimmancin gyare-gyaren sinadarai na kwanan nan da aka gabatar a cikin jerin amino acid da kuma masu haɗin gwiwa da kuma sababbin masu binciken bifunctional waɗanda suka inganta ƙayyadaddun ƙayyadaddun bayanai da ji na peptides da aka yi amfani da su a cikin cututtukan oncologic da jiyya..