Testagen as the name implies, is a bioregulatory peptide that promotes testosterone. Like many short peptides, Testagen crosses cell and nuclear membranes and interacts directly with DNA. Studies have shown that Testagen stimulates the anterior pituitary gland, increasing the release of thyroid stimulating hormones and ultimately T3 and T4 thyroid hormones. The fact that it can do this even in the absence of pituitary support suggests that it directly alters the expression patterns of proteins in the pituitary gland, a function that could explain its effect on testosterone levels. Finally, because Testagen 20mg affects the pituitary gland, it has effects on hemostasis and immunity, although these effects are not as pronounced as its effects on thyrotropin levels and testosterone.
Sequence
H-Lys-Glu-Asp-Gly-OH
CAS Number
/
Molecular Formula
C17H29N5O9
Molecular Weight
447.2
The thyroid gland, a part of the endocrine system, is important to metabolism, growth, and reproductive function. Dysfunction of the thyroid gland can lead to difficulties with memory and concentration, changes in heart rate, difficulty regulating body temperature, weight gain, high cholesterol levels, and trouble with reproductive function.
One of the many reasons that the thyroid gland malfunctions is due to failure of the pituitary gland, the gland that regulates it. In this case, levels of another hormone, TSH, decline and do not stimulate the thyroid gland. There are a number of reasons why this may happen, but research in birds suggests that the pituitary gland can be stimulated, directly, but administration of Testagen 20mg. Testagen appears to alter DNA expression profiles in the pituitary gland to raise TSH secretion. Studies show that this results in near-normal thyroid hormone levels[1], [2].
Testagen and Tesosterone Levels
Research suggests that Testagen 20mg may help to normalize testosterone levels and thus testicular function. This may be especially pertinent to aging men suffering from declines in testosterone levels and related problems like lower bone density, decrease muscle mass, erectile dysfunction, inhibited libido, problems with cognition, and decreased energy levels.
It is important to note that the benefits of Testagen 20mg on the pituitary gland may occur even if the dysfunction is caused by tumors, medications (e.g. steroids, morphine) infection, and or autoimmune conditions. Right now, research is in its early stages so it is difficult to delineate the specific settings in which Tesagen does and does not impact the pituitary gland.
Some or all of the benefit that Testagen has on testosterone levels may be directly linked to its effects on thyroid hormone levels. Research shows that hypothyroidism can lead to low testosterone levels that are subsequently normalized with thyroid hormone replacement therapy. Thyroid hormone replacement has also been shown to normalize free testosterone concentrations[3]. It stands to reason then that Testagen’s benefits on testosterone levels may, in fact, be attributable to its effects on thyroid hormone levels. More research needs to be completed in this area.
Testagen 20 mg and the Immune System
Research by Dr. Vladimir Khavinson has shown that peptides are capable of penetrating both cell and nuclear membranes to interact directly with DNA[4]. This epigenetic regulation of gene expression extends to the genes responsible for cell differentiation. Testagen 20mg has been shown by Dr. Khavinson to help push stem cells to differentiate into cells of the immune system, indicating that the peptide could have potential positive benefits on immune function[5]. This function may be especially useful in elderly individuals experiencing senescence and loss of cell differentiation secondary to chromatin condensation.
By virtue of its effects on the immune system, Testagen may be said to have anti-aging properties. By improving immune function and immune surveillance, Testagen could help to reduce the risk of a number of autoimmune disease as well as cancers that tend to increase in prevalence with age. It is important to note that immune function is often tied to thyroid function and that low thyroid hormone levels are often associated with increased risk of infection and poor immunity. The impact of Testagen 20mg on thyroid hormone levels may be a secondary contributor to its beneficial effects on immune function.
Testagen and Blood Clotting
Dr. Boris Kuznik, who is now retired, did some of the preliminary work with Dr. Khavinson on the role of Testagen and similar peptides in the blood system. His specialty of clotting, which is not a function of the immune system per se but is closely related and is, to some extent, influenced by the thyroid gland, led him to explore the ability of Testagen to improve hemostasis (blood clotting). Early research suggests that Testagen is useful in this setting and may, in fact, be able to normalize hemostasis in certain disease conditions.
Testagen Summary
Testagen is a short, bioregulatory peptide that has primary effects on the pituitary gland and ultimately the thyroid gland. As a result of its action on these two glands, Testagen is capable of normalizing testosterone production as well as thyroid hormone production in certain settings. By normalizing thyroid hormone production, Testagen has a moderate impact on the immune system. In these cases, Testagen can be conveniently thought of as resetting the pituitary gland to a more youthful state and thereby acting as an anti-aging peptide. Testagen is being researched for its ability to boost testosterone levels, improve thyroid hormone function, and stimulate the differentiation of stem cells in the immune system to improve immune function.
COA
HPLC
MS
- B. I. Kuznik, A. V. Pateiuk, N. S. Rusaeva, L. M. Baranchugova, and V. I. Obydenko, “[Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds],” Patol. Fiziol. Eksp. Ter., no. 1, pp. 14–18, Mar. 2010.
- B. I. Kuznik, A. V. Pateiuk, N. S. Rusaeva, L. M. Baranchugova, and V. I. Obydenko, “[Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds],” Adv. Gerontol. Uspekhi Gerontol., vol. 24, no. 1, pp. 93–98, 2011.
- A. W. Meikle, “The interrelationships between thyroid dysfunction and hypogonadism in men and boys,” Thyroid Off. J. Am. Thyroid Assoc., vol. 14 Suppl 1, pp. S17-25, 2004, doi: 10.1089/105072504323024552.
- L. I. Fedoreyeva, I. I. Kireev, V. K. Khavinson, and B. F. Vanyushin, “Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA,” Biochem. Biokhimii͡a, vol. 76, no. 11, Art. no. 11, Nov. 2011, doi: 10.1134/S0006297911110022.
- V. Khavinson, N. Linkova, A. Diatlova, and S. Trofimova, “Peptide Regulation of Cell Differentiation,” Stem Cell Rev. Rep., vol. 16, no. 1, pp. 118–125, Feb. 2020, doi: 10.1007/s12015-019-09938-8.
Article/Literature Citation Notes
The purpose of quoting the scientist and professor's article is to acknowledge, recognise and applaud the exhaustive development work that has been done to undertake this peptide research. The scientist does not in any way support or advocate the purchase, sale or use of this product for any reason, and MOL Changes has no affiliation or relationship, implied or otherwise, with the scientist.
warning
These products are intended for scientific purposes only for in vitro research and are not to be used for human, animal or unethical experiments, in vitro research (Latin: in glass) is conducted in vitro. These products are not drugs and are not approved by the Food and Drug Administration in any country for the prevention, treatment or cure of any medical condition, disease or illness. The introduction of this product into humans or animals in any form is strictly prohibited by law.
