Tetrapeptide-4 shine peptide na roba wanda aka yi amfani dashi azaman sashi mai aiki a cikin ƙirar fata..
An yadu amfani a anti-tsufa kayan shafawa, da farko don tada hankali collagen samuwar da extracellular matrix kira, rage zurfin wrinkle da kuma ƙara ƙarfin sautin fata.
Tare da yanayin kwanciyar hankali da fa'idodin rigakafin tsufa na ban mamaki, Tetrapeptide-4 ya zama ɗaya daga cikin sinadarai masu mahimmanci a cikin samfuran kula da fata na zamani.
Jeri
Gly-Glu-Pro-Gly
Lambar CAS
960608-16-6
Tsarin kwayoyin halitta
Saukewa: C14H22N4O7
Nauyin Kwayoyin Halitta
358.35
Tetrapeptide-4 Bincike mai alaƙa
An rarraba Tetrapeptide-4 azaman "peptide mai siginar", wanda ke nuna cewa yana aika sigina zuwa sel maimakon zama ainihin ɓangaren tsarin salula.
Babban aikinsa na rigakafin tsufa ya dogara ne akan sake ginawa da kiyaye matrix na fata na fata (ECM).
1.Gudanar da Collagen da Elastin Synthesis
Tsarin tsufa na fata shine farkon rugujewa a cikin ECM tare da asarar musamman da rashin aiki na collagen, elastin, kuma fibronectin.
Babban aikin Tetrapeptide-4 shine komawa ko rage jinkirin wannan tsarin tsufa.
Shaidu da yawa sun goyi bayan cewa Tetrapeptide-4 yana haɓaka haɓakar waɗannan mahimman sunadaran tsarin guda uku yadda yakamata..
Ta hanyar ƙarfafa haɓakar haɗin gwiwa na matakan su, Tetrapeptide-4 na iya inganta ingantaccen tsarin fata, rage wrinkles da kuma sa fata ta zama m da kuma na roba.
2.Yana ƙarfafawa Canji Factor-β (TGF-β) Saki
Yawancin karatu sun nuna a fili cewa Tetrapeptide-4 yana ɗaure ga takamaiman masu karɓa waɗanda ke kan membranes na fata., musamman a kan fibroblasts.
Wannan ɗaurin yana kunna ɓangarorin siginar intracellular.
Sakamakon ƙarshe na waɗannan cascades shine haɓaka abubuwan haɓaka haɓaka-β (TGF-β) samarwa.
TGF-β yana daya daga cikin mafi mahimmanci cytokines yana da hannu wajen daidaita haɗin matrix na extracellular.
Ana kiransa "Master sauya" mai sarrafa samar da collagen, elastin da fibronectin.
3.Ƙara yawan fibronectin da glycosaminoglycan samarwa
Hakanan yana ƙara samar da duka fibronectin da glycosaminoglycans (kamar hyaluronic acid), wanda ke taimaka wa fata samun ruwa sosai, yana haɓaka aikin shinge, kuma yana rage zurfin wrinkle.
Bayanan inganci game da Tetrapeptide-4 galibi sun dogara ne akan in-vitro ko ƙananan nazarin ɗan adam wanda masu ba da kaya suka bayar..
Daga cikin wadannan, nazari daya akai-akai ta hanyar tushe da yawa yana ba da shaidar ingantaccen inganci na farko.
A cikin binciken asibiti, 28 mata masu aikin sa kai shekaru 44-66 shafa wani kirim mai hana kumburin ciki 60 ppm Tetrapeptide-4.
Abubuwan da ake amfani da su sun yi amfani da samfurin sau ɗaya kowace rana don 8 makonni.
An ƙididdige zurfin wrinkles ta kayan aiki na musamman da nazarin hoton fuska.
Sakamakon ya nuna mahimmanci (p<0.05) raguwa a cikin zurfin wrinkle na periorbital da ƙafar hankaka bayan aikace-aikacen tetrapeptide-4 cream idan aka kwatanta da tushe.
Ƙarfafawa da kwandon fatar fuska an inganta su da kyau ba tare da rahotannin tasirin da ba a so.
Wannan binciken yana ba da shaida mai goyan bayan gyaran fata da tasirin tsufa na tetrapeptide-4.
Ana amfani da Tetrapeptide-4 galibi a cikin kowane nau'ikan samfuran rigakafin tsufa na fata waɗanda suka kama daga serums da creams na fuska zuwa creams na ido da kirim na wuya..
Yana rage zurfin da girma na a tsaye da tsauri wrinkles, musamman nasolabial folds da kafafun hankaka.
A lokaci guda, yana taimaka ma'anar jawline, adreshi ya zube, da kuma kara lalurar fata saboda asarar collagen bayan tsufa.
COA
HPLC
MS
