Tripeptide-29 shine peptide na kwaskwarima wanda ake amfani dashi sosai a cikin serums na rana, kayayyakin kula da bayan rana, da gyare-gyaren shingen bin hanyoyin kwalliya na likita iri-iri.
An samo shi daga ɓarkewar Gly-Pro-Hyp, wannan ƙaramin guntu yana wakiltar mafi girman maimaitawa da aka samu a cikin sarkar α1 na Nau'in I collagen; kula da Sau uku-helix conformation Na ce collagen shine babban aikin sa na farko.
Nazarin thermodynamic ya nuna wannan gutsuttsura na tripeptide don zama karko, an intramolecular hydrogen bond hanyar sadarwa (pyrrolidine zobe zuwa rukunin hydroxyl shine mabuɗin) muhimmanci mika ta in-vivo rabin rayuwa.
Mafi ƙarancin ƙira da kanta yana guje wa illolin da ke tattare da dogon sarƙoƙi na peptide, a fiye tsarin hydrophobic inganta fata permeability.
Jeri
Gly-Pro-Hyp
Lambar CAS
2239-67-0
Tsarin kwayoyin halitta
Saukewa: C12H19N3O5
Nauyin Kwayoyin Halitta
285.30
Tripeptide-29 Bincike mai alaƙa
1.Mabuɗin Ayyukan Halittu
Ana kiyaye cikakken ingancin sarkar mahaifa collagen α1; ana kwaikwayi sigina mara inganci, kunna fibroblast takamaiman hanyoyi zuwa haɗin haɗin collagen – samar da sabon collagen shine sakamakon ƙarshe, raguwar wrinkle kasancewa ɗaya daga cikin mafi yawan sakamako masu aunawa.
Hana wuce gona da iri na matrix metalloproteinase wani tasiri ne mai kyau, Ana dakatar da kirar enzyme mai lalata don tsirar collagen lafiya.
An katse halayen oxidation na sarkar, sinadarai matakin matakin farko na kariya na lalata ana isar da su (ana ƙarfafa shinge da ayyukan hydration).
Tsarin aiki mai ƙarfi na duk waɗannan abubuwan matakin matakin ƙwayoyin cuta suna gina ingantacciyar hanyar gyara fata da kuma hanyar rigakafin tsufa..
2.Collagen Regeneration
Babban kusanci da TβR-III (Mai canza girma factor beta receptor III) shine abin da ke saita Tripeptide-29 baya; Ana kwaikwayar siginar lalata da kyau.
Sabo, Tsarin sauti Nau'in I da III collagen an haɗa su azaman sakamako kai tsaye.
Mai ƙarfi, mafi ƙuruciyar dermis shine sakamakon da aka lura.
3.Hana Lalacewar Collagen
Tripeptide-29 yana hana yawan samar da matrix metalloproteinases (MMPs) cikin kwayoyin fata.
Ƙaddamar da ƙayyadaddun hanyoyin siginar intracellular da kuma bayyanar da abubuwa masu kumburi daban-daban sune mahimman hanyoyi a cikin wannan tsari..
Maganar halitta, MMP magana an danne; asarar cibiyoyin sadarwar collagen da aka kafa a baya yana raguwa.
An samar da ingantaccen yanayi don haɗawa da kiyaye sabon collagen.
Tsawaita bayyanar ƙuruciyar fata shine babban sakamako na wannan aikin; Ana kiyaye ƙarfin fata ta wannan ci gaba da tsari.
4.Kariyar Photoprotection da Haskakawa
Bincike ya nuna Tripeptide-29 yana samar da mai yawa Sau uku-helix conformation a kan m membrane na melanosomes.
Tyrosinase an kiyaye shi daga shiga cikin tantanin halitta, kai tsaye melanin don haka ana hana samarwa.
Lalacewar UV ga fata yana raguwa, koda sautin fata bayan tsawaita bayyanarwa yana faruwa.
Jajayen kunar rana mai tsanani, kumburi da kona majiyai suna da muhimmanci rage.
Na kullum daukar hoto Alamun ba sa kara muni a sakamakon haka.
Mai jituwa tare da kowane nau'i na fuskar rana ta kasuwanci, m photoprotection ne mai yiwuwa.
COA
HPLC
MS
