ʻO Cardiogen kahi peptide bioactive synthetic me ka hōʻike ʻana i nā hopena pale cardiovascular a me ka hiki ke hoʻihoʻi. Loaʻa mai ka noiʻi hoʻomau kanaka i ka pathogenesis nā maʻi cardiovascular, he lāʻau peptide synthetic piha.
Ka pale ʻana i ka maʻi cardiovascular, a ʻoi aku ka laulā pale ʻana i ka naʻau i nā mea ola, pili i ka lawe ʻana i nā ala hōʻailona kikoʻī; ʻO nā hormones a me nā neurotransmitters nā mea hoʻolaha mua.
Ua hoʻolālā ʻia ʻo Cardiogen mai ka hoʻomaka ʻana e hoʻohālike i kēia mau alahele a i ʻole e hoʻāla pono i ka protein hōʻailona hōʻailona(s) e hoʻokō i ia palekana.
ʻAʻole ia he lāʻau lapaʻau maoli, nā palena āpau e pili ana i nā peptides kūlohelohe (hoʻohaʻahaʻa wikiwiki, pōkole hapalua ola, haahaa bioavailability) ua lanakila ʻia i kahi pae koʻikoʻi.
Ua hōʻike nā haʻawina preclinical i nā hōʻemi nui o ka ʻehaʻeha o ka myocardial nui, hoʻomaikaʻi i ka hana ventricular hema, ka pale ʻana i nā mea ʻino hoʻoponopono hou ʻana o ka ventricular, a me ka pale ʻana i nā apoptosis a me necrosis o ka cardiomyocytes.
Hōʻike ʻia ka mana antioxidant ikaika, ka hoʻēmi ʻana i nā ʻano pōʻino oxidative a pau cardiomyocytes aiʻole nā pūnaewele endothelial vascular e pili pū ana.
Hōʻike nā haʻawina hou i ka hoʻonui ʻana i ka ikehu myocardial metabolism – ʻO ka maikaʻi o ka hana mitochondrial a me ka hoʻoulu ʻana o ka ikehu he mea hoihoi.
Ke noiʻi ʻia nei nā hopena anti-fibrotic i kēia manawa.
ʻano nui, ʻO ka synergistic cardioprotective a me ka therapeutic hiki ke hōʻike ʻia e Cardiogen.
Kaʻina
Ala-Glu-Asp-Arg
Helu CAS
/
ʻĀpana Molekala
C18H31N7O9
Kaumaha Molecular
489.486
Noi'i o Cardiogen Peptide
1.Ka mālama ʻana i nā maʻi cardiovascular a ma hope ʻeha reperfusion
ʻO ka hōʻeha Reperfusion ponoʻī ka hopena o ka poʻe e ʻimi nei e mālama.
ʻO nā poloka i loko o ka ʻōnaehana cardiovascular alakaʻi i ischemia/hypoxia o ka myocardium; hoʻihoʻi pololei i ke kahe koko (ʻokiʻoki a i ʻole) ke kumu o keia poino nui.
cardiogenic, ma o ka ho'āla 'ana i nā ala intracellular i ha'i mua 'ia (PI3K-Akt lilo i pookela iwaena o lakou), hoʻohālike i nā pane palekana endogenous o ke kino.
Wehe ana o ka mitochondrial permeability transition pore(mPTP) ʻo ia kekahi o nā mea hope loa, hiki ʻole ke hoʻololi i nā ʻanuʻu i ka make cardiomyocyte, ua hoʻopaʻa pono ʻia.
Hoʻopakele i ka mea maʻi mai ka piha a kokoke i ka piha hōʻeha ʻana ʻo ia ka hopena hopena maikaʻi loa – liʻiliʻi, ʻoi aku ka maʻamau’ ka nui o ka myocardium a me nā mea a pau, ʻO ia ka pahuhopu maoli o ka lāʻau cardiogenic.
2.Kāohi i ka apoptosis
I nā hiʻohiʻona o ke koʻikoʻi o ka naʻau a me ka hōʻeha reperfusion, Ua hōʻike ʻia ka cardiogen e kāohi nui i ka apoptosis.
Ho'ā pono lākou i ke kī kinase e like me Akt, keʻakeʻa i ka hana protein pro-apoptotic ma o phosphorylation, a i kekahi mau mea e hoʻonui i ka hana protein anti-apoptotic.
Loaʻa ke ʻano o ka hoʻopaʻa ʻana i ka pae hormonal o ka apoptosis ma o kēia mau hana.
Hōʻike kēia noiʻi i ka mana nui no ka cardiogen – hoʻopakele i nā maʻi maʻi maʻi maʻi puʻuwai hoʻokahi noi, hoʻoponopono i nā ʻano like ʻole o ka maʻi puʻuwai mau, lohi ana (inā ʻaʻole kū) ka nalo ʻana o nā cell myocardial, a ma ka hoʻopaneʻe ʻana i nā ʻano a pau o ka holomua o ka naʻau.
3.Hoʻomaikaʻi i ka metabolism ikehu cardiac
Hoʻonui ka Cardiogens i ka ikehu metabolism i loko o nā pūnaʻi cardiac; ʻO ka pale mua o ka wehe ʻana o ka mPTP kahi ala mua i hoʻohana ʻia no kēia kumu.
ʻO ka hoʻohaʻahaʻa ʻana i ka pōʻino oxidative i ke kaulahao transport electron mitochondrial e hiki ai i ka mitochondria ke mālama i ka hiki ke membrane a i kahi kūlana kiʻekiʻe..
Pono adenosine triphosphate (ATP) hiki ke hana, he ʻano ikehu hoʻomau mau e hoʻolako ʻia ana i ka puʻuwai nawaliwali.
ʻO ka hoʻopaʻa ʻana o ka puʻuwai kūpaʻa a me nā ʻano pili āpau o ka hana puʻuwai pōkole / lōʻihi e pili ana i kēia lako ikehu paʻa..
4.ʻO nā hopena antioxidant a me nā hopena anti-inflammatory
Hōʻike ʻia nā hopena antioxidant indirect e ka cardiogen.
Hoʻola pololei i kekahi mau ala hōʻailona (ʻO Akt ka laʻana nui) alakaʻi i ka upregulation o nā ʻōnaehana antioxidant endogenous o ke kino.
Glutathione peroxidase a me nā enzymes like ʻole e ʻike i ka hoʻonui ʻana i ka ʻōlelo, hana 'ana i ka 'olu'olu’ kaiapuni no nā pūnaeau cardiovascular.
Kāohi i ka Myocardial Fibrosis a me Ventricular Remodeling: ʻO ka fibrosis cardiac ponoʻī ke kumu nui o ka maʻi puʻuwai a i ʻole ka pau ʻole o ke kino.
ʻO ka fibrosis i hoʻoulu ʻia i ke koʻikoʻi lōʻihi a me ka hoʻoponopono hou ʻana o ka ventricular ma hope o ke kumu o ka hopena o ka maʻi puʻuwai..
ʻO ka hana Cardiogen ma nā mea i ʻōlelo ʻia ma luna (ʻO ka anti-apoptotic ka mea nui) a me ka pale pololei i nā hōʻailona pro-fibrotic, he wahi noiʻi koʻikoʻi a kākau maikaʻi ʻia.
ʻO ka hiki o Cardiogen ke hoʻopaneʻe a pale i ka myocardial fibrosis he ʻāpana o kāna ʻōlelo hoʻohiki holoʻokoʻa.
COA
HPLC
MS
