Cardiogen yog ib qho hluavtaws bioactive peptide nrog kev ua kom pom kev tiv thaiv kab mob plawv thiab rov qab muaj peev xwm.. Muab los ntawm kev tshawb fawb tib neeg mus rau hauv lub kab mob ntawm cov kab mob plawv, nws yog ib qho tshuaj peptide tag nrho.
Kev tiv thaiv kab mob plawv, los yog ntau dua cardioprotection nyob rau hauv cov tsiaj muaj sia, koom nrog kev sib kis ntawm cov kev taw qhia tshwj xeeb; Cov tshuaj hormones thiab neurotransmitters yog thawj tus neeg nruab nrab.
Cardiogen tau tsim los ntawm qhov pib mus rau kev ua raws li txoj hauv kev no lossis ncaj qha qhib qhov tseem ceeb hauv qab cov cim qhia protein(s) kom ua tiav hais tias kev tiv thaiv.
Tsis yog ib tug naturally extracted tshuaj, tag nrho cov kev txwv tsis pub muaj cuam tshuam nrog ntuj peptides (ceev degradation, luv ib nrab neej, qis bioavailability) tau dhau mus rau qhov tseem ceeb.
Cov kev tshawb fawb preclinical tau pom tias muaj kev txo qis hauv qhov tseem ceeb myocardial infarct qhov loj, txhim kho sab laug ventricular muaj nuj nqi, tiv thaiv tsis zoo ventricular remodeling, thiab tiv thaiv ob qho tib si apoptosis thiab necrosis ntawm cardiomyocytes.
Ib lub peev xwm antioxidant muaj zog kuj tau nthuav tawm, mitigating txhua hom kev puas tsuaj oxidative tshwj xeeb rau ob qho tib si cardiomyocytes los yog nrog vascular endothelial hlwb.
Cov kev tshawb fawb tsis ntev los no taw qhia txog kev txhim kho myocardial zog metabolism – optimization ntawm mitochondrial muaj nuj nqi thiab lub zog ntau lawm yog tshwj xeeb txaus siab.
Anti-fibrotic teebmeem tam sim no raug tshawb xyuas.
Multidimensional, synergistic cardioprotective thiab kho muaj peev xwm yog dab tsi Cardiogen sawv cev.
Ib ntus
Ala-Glu-Asp-Arg
CAS Nr
/
Molecular Formula
C18H31N7O9
Molecular Luj
489.486
Kev tshawb fawb ntawm Cardiogen Peptide
1.Kho cov kab mob plawv thiab tom qab reperfusion raug mob
Reperfusion raug mob nws tus kheej yog qhov kawg point ntau tam sim no nrhiav kev kho.
Blockages nyob rau hauv cov hlab plawv system ua rau ischemia/hypoxia ntawm myocardium; ncaj qha rov kho cov ntshav khiav (phais lossis lwm yam) ua rau qhov kev puas tsuaj loj heev.
cardiogenic, los ntawm kev ua kom cov txheej txheem yav dhau los tau hais los ntawm intracellular (PIB 3K-Akt ua thawj ntawm lawv), mimics lub cev tus kheej endogenous tiv thaiv teb.
Qhib ntawm lub mitochondrial permeability hloov pore(mPTP) ua ib tug kawg, irreversibly puas cov kauj ruam hauv cardiomyocyte tuag, yog ntse inhibited.
Rescuing tus neeg mob los ntawm tag nrho los yog ze rau tag nrho infarction yog qhov kawg kawg nkaus – me me, mas 'normal’ qhov loj ntawm myocardium thiab txhua yam hauv qab no, yog lub hom phiaj tseeb ntawm kev kho mob cardiogenic.
2.Inhibiting apoptosis
Nyob rau hauv cov qauv ntawm mob plawv kev nyuaj siab thiab reperfusion raug mob, cardiogen tau pom zoo kom txo qis apoptosis.
Lawv ncaj qha qhib tus yuam sij kinases zoo li Akt, inhibit pro-apoptotic protein kev ua ntawm phosphorylation, thiab hauv qee kis txhim kho kev ua haujlwm ntawm cov protein apoptotic.
Ib daim ntawv ntawm ncaj qha hormonal-theem suppression ntawm apoptosis yog ua tiav los ntawm cov txheej txheem no.
Qhov kev tshawb fawb no qhia tias muaj peev xwm tseem ceeb rau cardiogen – rescuing cov neeg mob mob plawv yog ib daim ntawv thov, tswj ntau yam ntawm cov kab mob plawv, qeeb (yog tsis nres) poob ntawm myocardial hlwb, thiab los ntawm kev ncua ncua txhua hom kev mob plawv tsis ua haujlwm.
3.Txhim kho plawv zog metabolism
Cardiogens txhim kho lub zog metabolism hauv cov hlwb; front-end inhibition ntawm mPTP qhib yog thawj txoj kev siv rau lub hom phiaj no.
Txo oxidative kev puas tsuaj rau lub mitochondrial electron thauj saw tso cai rau lub mitochondria kom muaj peev xwm ntawm daim nyias nyias thiab mus rau ib tug loj degree ntawm kev ncaj ncees..
Muaj txiaj ntsig adenosine triphosphate (ATP) ntau lawm ces ua tau, ib daim ntawv ruaj khov ntawm lub zog tau muab rau lub plawv tsis ua haujlwm.
Stable cardiac contractility thiab tag nrho cov ntaub ntawv muaj feem xyuam rau lub sij hawm luv / ntev lub plawv muaj nuj nqi nyob ntawm qhov ruaj khov zog mov..
4.Antioxidant thiab Anti-inflammatory teebmeem
Indirect antioxidant teebmeem kuj tshwm sim los ntawm cardiogen.
Kev ua kom ncaj qha ntawm qee qhov kev taw qhia (Akt yog tus piv txwv tseem ceeb) ua rau upregulation ntawm lub cev endogenous antioxidant systems.
Glutathione peroxidase thiab lwm yam enzymes zoo sib xws pom kev nthuav qhia ntxiv, tsim kom muaj ntau 'favorable’ ib puag ncig rau cov kab mob plawv.
Inhibition ntawm Myocardial Fibrosis thiab Ventricular Remodeling: Cardiac fibrosis nws tus kheej yog thawj qhov ua rau mob plawv lossis lub cev tsis ua haujlwm.
Kev ntxhov siab ntev ua rau mob fibrosis thiab kev hloov kho ventricular tom ntej yog tsawg kawg yog ib feem ntawm lub luag haujlwm rau theem kawg ntawm kab mob plawv.
Cardiogen kev txiav txim ntawm cov lus hais saum toj no (anti-apoptotic yog qhov tseem ceeb) thiab ncaj qha inhibition ntawm pro-fibrotic signals, yog ib qho tseem ceeb heev thiab muaj ntaub ntawv zoo ntawm kev tshawb fawb.
Cardiogen lub peev xwm los ncua lossis tiv thaiv myocardial fibrosis yog ib feem ntawm nws txoj kev cog lus kho mob tag nrho.
COA
HPLC
MS
