Adamax [Ac-MEHFPG-AG-Nh2] is an analog of Semax. It has an adamantane part similar to P21.
In short, it is a more powerful version of Semax. The developers at Ceretric developed Adamax because it has more potential than the basic signaling protein.
Adamax helps humans by increasing endurance, speeding recovery from strenuous physical activity, and stimulating brain activity over time.
Studies have shown that Adamax improves athletes’ endurance 2-3 times more than other Semax analogs due to its unique adamantane fraction and increased bioactive stability after crossing the blood-brain barrier (BBB).
Adamax is technically an N-acetyl Semax base with a C-terminal portion restricted by the P21 adamantyl group.
It increases brain-derived neurotrophic factor (BDNF) levels and enhances hippocampal TrkB receptor sensitivity
Sequence
Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-OH
CAS Number
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Molecular Formula
C22H52N16O6
Molecular Weight
1032.24
Adamax research area
Adamax works by mimicking the effects of the activity-dependent neuroprotective protein (ADNP), a key regulator of brain development and function. ADNP is essential for neurite outgrowth, synapse formation, and neuroprotection. Adamax, a synthetic peptide derived from ADNP, binds to microtubule end-binding proteins and promotes microtubule assembly, stability, and transport. This action enhances neuronal survival, plasticity, and connectivity, leading to improved cognitive function and memory.
Adamax also stimulates the release of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which support the growth, maintenance, and survival of neurons. Additionally, Adamax exhibits potent antioxidant and anti-inflammatory properties, protecting neurons from oxidative stress and inflammation-induced damage. By reducing the accumulation of beta-amyloid plaques and tau phosphorylation, Adamax may help prevent or slow the progression of neurodegenerative diseases like Alzheimer’s.
- Enhances cognitive function and memory: Adamax improves learning, memory retention, and recall by promoting synaptic plasticity and neurogenesis in the hippocampus and cortex.
- Neuroprotective properties: Adamax protects neurons from oxidative stress, inflammation, and toxicity, reducing the risk of age-related cognitive decline and neurodegenerative diseases.
- Promotes neuronal survival and regeneration: By stimulating the release of neurotrophic factors, Adamax supports the survival, growth, and regeneration of neurons, maintaining brain health and function.
- Reduces beta-amyloid and tau pathology: Adamax may help prevent or slow the progression of Alzheimer’s disease by reducing the accumulation of beta-amyloid plaques and tau phosphorylation, two hallmarks of the disease.
- Improves mood and reduces anxiety: Adamax has been shown to have anxiolytic and antidepressant effects, potentially by modulating the levels of neurotransmitters such as serotonin and dopamine.
- Enhances sleep quality: Adamax may improve sleep quality and duration by regulating the sleep-wake cycle and promoting the expression of sleep-related genes.
- Potential treatment for neurodevelopmental disorders: Adamax may be beneficial in treating neurodevelopmental disorders such as autism and fragile X syndrome, which are characterized by cognitive deficits and impaired social interaction.
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Article/Literature Citation Notes
The purpose of quoting the scientist and professor's article is to acknowledge, recognise and applaud the exhaustive development work that has been done to undertake this peptide research. The scientist does not in any way support or advocate the purchase, sale or use of this product for any reason, and MOL Changes has no affiliation or relationship, implied or otherwise, with the scientist.
warning
These products are intended for scientific purposes only for in vitro research and are not to be used for human, animal or unethical experiments, in vitro research (Latin: in glass) is conducted in vitro. These products are not drugs and are not approved by the Food and Drug Administration in any country for the prevention, treatment or cure of any medical condition, disease or illness. The introduction of this product into humans or animals in any form is strictly prohibited by law.
