O le Cardiogen o se peptide bioactive synthetic ma faʻaalia aafiaga puipuia cardiovascular ma toe faʻaleleia. Mafua mai su'esu'ega fa'aauau a tagata i le pathogenesis o ma'i cardiovascular, o se vailaʻau peptide faʻapipiʻi atoatoa.
Puipuiga cardiovascular, pe sili atu le lautele cardioprotection i mea ola, e aofia ai le fa'asalalauina o ala fa'ailoga fa'apitoa; hormones ma neurotransmitters o le puluvaga muamua.
O le Cardiogen na mamanuina mai le amataga e faʻataʻitaʻi i nei auala pe faʻagaoioi saʻo le ki lalo ole porotini faʻailoga(s) ia ausia lea puipuiga.
E le o se fualaau fa'alenatura, o tapulaʻa faʻapitoa uma e fesoʻotaʻi ma peptides faʻanatura (vave fa'aleagaina, puupuu afa ola, maualalo bioavailability) ua faatoilaloina i se tulaga taua.
O suʻesuʻega faʻapitoa na faʻaalia ai le faʻaitiitia tele o myocardial infarct tele, fa'aleleia le galuega agava'a ventricular, puipuia o le leaga toe fa'aleleia o ventricular, ma puipuiga mai apoptosis ma necrosis o cardiomyocytes.
O lo'o fa'aalia fo'i se malosi malosi o le antioxidant, faaitiitia ituaiga uma o oxidative faaleagaina faapitoa i le lua cardiomyocytes po'o sela endothelial vascular o lo'o i ai.
O suʻesuʻega talu ai nei o loʻo faʻaalia i le faʻaleleia o le metabolism o le myocardial energy – optimization o galuega mitochondrial ma le gaosiga o le malosi o se mea e sili ona fiafia i ai.
O lo'o su'esu'eina nei a'afiaga o le anti-fibrotic.
Tu'ufa'atasi, synergistic cardioprotective ma therapeutic gafatia o le Cardiogen suitulaga.
Fa'asologa
Ala-Glu-Asp-Arg
Numera CAS
/
Fuafua mole
C18H31N7O9
Molecular Weight
489.486
Suʻesuʻega ole Cardiogen Peptide
1.Togafitiga o faʻamaʻi cardiovascular ma mulimuli ane manu'a reperfusion
Reperfusion manua lava ia o le mea mulimuli lea o loʻo taumafai nei le toʻatele e togafitia.
O poloka i totonu o le cardiovascular system e tau atu i ischemia/hypoxia o le myocardium; toe faʻaleleia saʻo o le tafe toto (taotoga po'o se isi mea) mafua ai lenei fa'aleagaina tele.
cardiogenic, e ala i le faʻagaoioia o auala intracellular na taʻua muamua (PI3K-Akt le avea ma tulaga sili ia i latou), fa'ata'ita'i i tali puipui a le tino.
Tatalaina o le mitochondrial permeability transition pore(mPTP) o se tasi o mulimuli, la'asaga fa'aleagaina e le mafai ona fa'afoliga i le oti cardiomyocyte, ua taofia manuia.
Fa'asaoina o le ma'i mai le tumu po'o le latalata atoa infarction o le taunuuga sili lea ona lelei – laiti, sili ‘ona masani ai’ myocardium lapoa ma mea uma e mulimuli mai, o le sini moni o togafitiga cardiogenic.
2.Taofi apoptosis
I faʻataʻitaʻiga o le faʻamaʻi faʻamaʻi masani o le fatu ma le faʻaleagaina o manuʻa, cardiogen ua faʻaalia e matua taofiofia le apoptosis.
Latou te fa'agaoioia sa'o ki kinase pei o Akt, fa'alavelave le gaioioiga porotini pro-apoptotic e ala i phosphorylation, ma i nisi tulaga e faʻaleleia ai le gaioiga anti-apoptotic protein.
O se ituaiga o tuusa'o o le hormonal-level suppression of apoptosis e maua e ala i nei faiga.
O lenei suʻesuʻega o loʻo faʻaalia ai le taua tele mo le cardiogen – laveai tagata mama'i tigaina fatu e tasi le talosaga, fa'atonutonu vaega 'ese'ese o fa'ama'i fatu tumau, fa'agesegese (a le taofi) le leiloa o sela myocardial, ma e ala i le faʻalauteleina o le faʻatuai o ituaiga uma o le faʻasolosolo ole fatu.
3.Faʻaleleia le metabolism malosi o le loto
Cardiogens e faʻaleleia le metabolism malosi i totonu o sela fatu; fa'amata'u pito i luma o le tatalaina o le mPTP o se auala muamua e fa'aaogaina mo lenei fa'amoemoe.
O le faʻaitiitia o le faʻaleagaina o le oxidative i le mitochondrial electron transport chain e mafai ai e le mitochondria ona faʻatumauina uma le gafatia o le membrane ma i se tulaga maualuga le faʻatulagaina faʻamaoni..
Lelei adenosine triphosphate (ATP) ona mafai lea ona gaosia, ose ituaiga gafataulimaina o le malosi o loʻo tuʻuina atu i le fatu vaivai.
E fa'alagolago le malosi ole fatu fa'amautu ma ituaiga uma e feso'otai i ai ole gaogao pu'upu'u/umi ole fatu i lenei sapalai malosi..
4.Antioxidant ma Anti-inflammatory Aafiaga
E fa'aalia fo'i e le cardiogen a'afiaga fa'a'a'ai fa'ala'au.
Fa'agaoioia sa'o o nisi ala fa'ailoga (Akt o le faʻataʻitaʻiga sili) e taʻitaʻia ai le faʻaleleia o le tino o le tino.
Glutathione peroxidase ma isi enzymes tutusa e va'aia le fa'atuputeleina o fa'aaliga, fatuina o se sili atu 'lelei’ siosiomaga mo sela cardiovascular.
Taofi ole Myocardial Fibrosis ma Ventricular Remodeling: O le fatu fibrosis lava ia ose mafua'aga autu o le ma'i fatu tuga po'o le fa'aletonu o totoga.
Fa'aumiumi fa'aoso fa'aoso fibrosis ma toe fa'afouga ventricular mulimuli ane e nafa ma le fa'ai'uga o fa'ama'i fatu..
Gaioiga cardiogen i luga o mea taua ua taua i luga (anti-apoptotic o le mea autu) ma fa'alavelave fa'asagatonu o fa'ailoga pro-fibrotic, ose vaega taua tele ma fa'amaumau lelei o su'esu'ega.
Ole malosi ole Cardiogen e fa'atuai pe puipuia ai le myocardial fibrosis ose vaega o lana folafolaga fa'afoma'i atoa.
COA
HPLC
MS
