1.Other Names of SYN-AKE：
SYN-AKE is a synthetic peptide that mimics the activity of the snake toxin venom of Waglerin I.Additionally, it is also known as a snake venom peptide or snake-venom-based tripeptide (Glu-Val-Trp) .
2.How SYN-AKE Works:
Specifically, it can interact with the body’s natural processes and selectively bind to muscle-type nicotinic acetylcholine receptors. As a result, this inhibits the transmission of acetylcholine (ACh) signals and blocks the contraction of the neuromuscular junction (NMJ).Consequently, this causes the instant minimization of the generation of wrinkles and smile lines.Moreover, SYN-AKE has been subjected to clinical trials and proven quite safe and bioactive.
Sequence
H-bAla-Pro-Dab-NHBn
CAS Number
823202-98-8
Molecular Formula
C19H29N5O3
Molecular Weight
495.6 g/mol
SYN-AKE Related Research
What Is SYN-AKE
SYN-AKE can act on acetylcholine receptors in muscle cells, effectively interfering with the binding of neurotransmitters and receptor.This local process is safer and more comfortable than botulinum toxin 1 and can significantly improve dynamic wrinkles caused by repeated muscle contraction.
Research Findings On SYN-AKE
1.In vitro studies
According to research,in vitro studies have shown that SYN-AKE’s IC50(half maximal inhibitory concentration) for human nAChRs(Nicotinic acetylcholine receptor) is 0.18 μM, which is notably 70% of the concentration of the natural Waglerin-1.Furthermore, in vitro, low concentrations of SYN-AKE were found to reduce the skin’s response to electrical muscle stimulation by 62%, which directly proves its ability to inhibit muscle contraction.
2.Clinical Study on Crow’s Feet
Researchers conducted a double-blind study by recruiting 33 women who with moderate to severe crow ‘s feet.Participants applied a skincare product containing 0.01% SYN-AKE.After one month, measurements using high-resolution optical profilometry showed a significant 32% reduction in wrinkle depth and a 27% decrease in wrinkle volume (P=0.007) compared to the placebo group
Additionally,researchers evaluated that 82% of the participants had visible improvements in their skin wrinkles, and there were no adverse reactions such as redness, peeling, or itching. This further proves the safety and effectiveness of SYN-AKE.
3.Synergistic Anti-Aging Effects
In another study, researchers proved that SYN-AKE can combine with MYMD-1 to achieve a dual anti-aging effect.
This study shows that SYN-AKE-MYMD can ：
- reduce wrinkles
- promote skin whitening in vitro
- inhibit inflammation
Moreover, it prevents cells from releasing reactive oxygen species that damage DNA, thereby protecting telomerase and achieving a comprehensive anti-aging effect.
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Article/Literature Citation Notes
The purpose of quoting the scientist and professor's article is to acknowledge, recognise and applaud the exhaustive development work that has been done to undertake this peptide research. The scientist does not in any way support or advocate the purchase, sale or use of this product for any reason, and MOL Changes has no affiliation or relationship, implied or otherwise, with the scientist.
Warning
These products are intended for scientific purposes only for in vitro research and are not to be used for human, animal or unethical experiments, in vitro research (Latin: in glass) is conducted in vitro. These products are not drugs and are not approved by the Food and Drug Administration in any country for the prevention, treatment or cure of any medical condition, disease or illness. The introduction of this product into humans or animals in any form is strictly prohibited by law.
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