Vesugen shine tripeptide na roba wanda ya ƙunshi amino acid guda uku (lysine-glutamic acid-aspartic acid, KED). Tsarinsa ya samo asali ne daga hadaddun peptide wanda ke ware daga jijiyar jijiyoyin jikin dabbobin matasa, wanda ke goyan bayan gyaran gyare-gyare da tsarin aiki na tsarin jijiyoyin jini, tare da mayar da hankali na farko akan lafiyar cibiyar sadarwar microvascular. Bincike da haɓaka irin wannan nau'in bioregulator na peptide sun dogara ne akan aikin da aka gudanar a St. Petersburg Cibiyar Bioregulation da Gerontology, da nufin inganta jijiyoyin jini homeostasis ta hanyar kwaikwayi gutsutsun peptide na halitta.
Jeri
Lys-Glu-Asp
Lambar CAS
/
Tsarin kwayoyin halitta
C₁₆H₂₇N₅O₈
Nauyin Kwayoyin Halitta
390.38
Binciken Vesugen
1.Ci gaba da Tushen Vesugen
Ci gaban Vesugen ya sami wahayi ne ta hanyar nazarin hadadden peptide mai suna "Ventfort®", samu daga magudanar jinin matasa dabbobi. Masu bincike sun gano Vesugen tripeptide a cikin wannan hadaddiyar giyar kuma sun dauki shi wani muhimmin sashi mai aiki da ke da alhakin ayyukan sarrafa jijiyoyin jini.. Daga baya an haɗa Vesugen ta hanyar sinadarai cikin tsafta. A matsayin ɗan gajeren peptide bioregulator, ana zaton don gyara microvessels, inganta jini, da kuma tallafawa elasticity na jijiyoyin jini, ta haka mai yiwuwa magance farkon alamun tsufa na jijiyoyin jini.
2.Tsarin aikin Vesugen ya ƙunshi matakan salon salula da tsarin kwayoyin halitta
(1).Ƙaddamar da Yaɗuwar Kwayoyin Halitta da Bambance-bambance
Babban tsarin da aka tsara na Vesugen shine gyare-gyaren haɓakar ƙwayoyin jijiyoyi na endothelial. Kwayoyin endothelial suna samar da Layer guda ɗaya mai rufin tasoshin jini, kuma yaduwar su da ƙaura suna da mahimmanci don gyaran jijiyoyi (angiogenesis) da kiyaye mutuncin jijiyoyin jini. The Ki-67 protein shi ne ingantaccen alamar haɓakar tantanin halitta, tare da matakin furcin sa yana da alaƙa da aikin mitotic.
Ƙarin zurfafan simintin docking na ƙwayoyin cuta suna ba da shawarar cewa Vesugen na iya ɗaure zuwa yankin mai tallata kwayoyin halitta. (MKI67) shigar da furotin Ki-67, ta haka epigenetically daidaita magana da kuma inganta yaduwar tantanin halitta. Wannan binciken yana ba da takamaiman bayanin ilimin halitta don abin da Vesugen ya faɗi “gyaran jijiyoyi” aiki-wato, gyare-gyaren tasoshin da suka lalace ta hanyar inganta haɓakar sel endothelial jijiyoyi¹.
(2).Dokokin Maganar Gene da Chromatin State
Vesugen na iya ɗaure musamman ga DNA, daidaita yanayin chromatin da ayyukan kwafin kwayoyin halitta, wanda ke shafar haɗakar sunadarai daban-daban masu alaƙa da aikin jijiyoyin jini.
Misali, yana iya rage bayyanar cututtuka masu kumburi (kamar CXCL12) da jinkirtawa salon salula².
(3).Inganta Angiogenesis da Gyara
Gwaje-gwajen in vitro sun nuna cewa Vesugen yana yin tasirin kariya akan ƙwayoyin jijiyoyin jini, inganta microcirculation da inganta elasticity na jijiyoyin bugun gini. Waɗannan abubuwan haɗin gwiwar suna ba da gudummawa ga yuwuwar sa don gyara ƙananan jiragen ruwa, inganta jini kwarara, da kuma mayar da farkon tsufa na jijiyoyin jini.
Yana iya shiga tsakiya ta hanyar jigilar peptide (misali, Pept1 da Lat1), hulɗa tare da DNA ko tarihin tarihi, kunna cascades siginar salula, kuma ta haka yana haɓaka haɓakar elastin na jijiyoyin jini da haɓaka microcirculation³.
(4).Haɓaka Juriya na Damuwa da Ƙarfin Antioxidant
Vesugen na iya inganta juriyar kwayoyin halitta zuwa yanayin damuwa kamar hypoxia da rage lalacewar oxidative ga jijiyoyi da jijiyoyi., mai yuwuwa ta hanyar daidaita hanyoyin siginar intracellular (misali, PI3K/ACT).
3.Tasirin Neuroprotective da Faɗin Aikace-aikace
Bincike ya nuna cewa Vesugen yana ƙara yawan dendritic spines-haɗe da filastik synaptic-a cikin ƙananan ƙwayoyin hippocampal, a kaikaice yana goyan bayan lafiyar microvascular na cerebral da kwararar jini.
Nazarin dabbobi ya nuna cewa Vesugen na iya kare jijiyoyin kwakwalwa daga lalacewar hypoxic.
4.Aikace-aikace na Clinical da Amfani
Aikace-aikacen Vesugen sun fi mayar da hankali kan kula da lafiyar zuciya da cututtukan zuciya. Ana ba da shawarar don yanayi daban-daban masu alaƙa da jijiyoyin jini, ciki har da jijiya hauhawar jini, jijiyoyin jini atherosclerosis, varicose veins, thrombophlebitis, da cututtuka na microcirculation na gida (misali, trophic ulcers)⁴.
Bugu da kari, ana amfani da shi don tallafawa yanayin da ke tattare da al'amurran da suka shafi zagayawan jini na cerebral (kamar atherosclerosis na cerebral da sequelae na cututtuka na cerebrovascular) kuma don rigakafin raguwar shekaru masu alaƙa da aikin jijiyoyin jini.
A wasu aikace-aikace, Ana kuma bincika Vesugen don rage tasirin damuwa-nauyin tunani da matsanancin yanayin muhalli akan tsarin jijiyoyin jini¹.
5.Takaitawa da Matsayin Yanzu
Vesugen, a matsayin wakili na tushen peptide wanda ke nufin lafiyar jijiyoyin jini, yana aiki ta hanyar ka'idojin matakin tsarin halitta da inganta aikin salula. A halin yanzu ana amfani da shi da farko a cikin magungunan bioregulator a Rasha da sassan Turai.
COA
HPLC
MS
