Pentide mai jawo bacci Delta (DSIP) aiki ne na ilimin halitta neuropeptide wanda ya ƙunshi amino acid tara. Gano DSIP yana wakiltar canji a cikin fahimtar tsarin barci - daga yanayin da ya gabata na takamaiman tsakiya na tsakiya wanda ke sarrafa barci gaba ɗaya zuwa gane rawar da masu kula da barci suka taka..
Wannan peptide yana nuna faɗuwar ayyuka na ilimin lissafin jiki da takamaiman tsarin aiki. Ƙarfinsa don ketare cikin sauri shingen jini-kwakwalwa(BBB) yana daya daga cikin fitattun kaddarorinsa; sa hannu wajen tsara tsarin hypothalamic-pituitary-adrenal (HPA) axis da kuma tasiri akan tsarin tsarin homeostasis duk tasiri ne da aka rubuta sosai.
Bayan ainihin ayyukan sarrafa bacci (inganta barci mai zurfi, ingantattun gine-ginen barci, da ingantaccen ingancin bacci), DSIP yana nuna ƙarfi neuroprotective da, zuwa wani gagarumin matsayi, iya gyarawa. Inganta juriya na neuronal zuwa nau'i-nau'i daban-daban na wuce gona da iri shine babban misali na wannan.
Endocrine tsarin kuma thermoregulation Hakanan an kafa ayyukan DSIP. Kwanan nan, antioxidant da kuma detoxification an lura da ayyuka.
Jeri
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Lambar CAS
62568-57-4
Tsarin kwayoyin halitta
Saukewa: C35H48N10O15
Nauyin Kwayoyin Halitta
848.33
Bincike Na Delta Barci Inducing peptide (DSIP)
1.Illolin Barci Da Ke Kawowa
Tsarin bacci shine aikin farko da aka fi dangantawa da DSIP. A m da zaɓin gabatarwa na barci a hankali shine mafi yawan rahotannin tasirin sa. Taimakon barci na waje na gargajiya yana aiki ta hanyoyi daban-daban; DSIP, a matsayin endogenous neuroregulatory peptide, physiologically modulates (a cikin tsari mai kyau) gine-ginen barci na mai amfani. Ƙara tsawon lokacin barci mai zurfi shine haɗin kai tsaye na ingantaccen ingancin barci.
Nazarin da ya shafi 400 marasa lafiya fama da tsanani rashin barci, wanda ya sami ci gaba da allurar DSIP har tsawon mako guda, ya nuna gagarumin ci gaba a duk abubuwan da aka auna na ingancin barci. Marasa lafiya da neurotic irritability, musamman, ya nuna alamar haɓakawa na daidaitawa ga abubuwan motsa jiki na waje bayan allura.
Waɗannan sakamakon sun nuna ƙarfin rawar da DSIP ke takawa a cikin tsarin bacci da yuwuwar sa wajen magance cututtukan jijiya.
2.Tsarin Zazzaɓin Jiki da Tsarin Aiki na Motoci
Wasu magungunan da ke haɓaka aikin dopamine na kwakwalwa na iya canza yanayin jiki. DSIP yana hulɗa tare da waɗannan magunguna, haifar da sauye-sauyen da aka ambata.
Nazarin a cikin beraye ya nuna cewa ƙananan zuwa matsakaicin allurai na DSIP sun rage yawan motsa jiki da zafin jiki a ƙarƙashin yanayin 4°C..
Lokacin da aka mayar da beraye zuwa yanayin 22°C, Gudanar da DSIP yana da alaƙa da haɓakar zafin jiki.
3.Endocrine Regulatory Aiki
Axis HPA shine ainihin neuroendocrine tsarin don amsa damuwa na jiki.
Overactivation na wannan tsarin yana haifar da rashin daidaituwa, matakan cortisol na yau da kullun. DSIP yana magance wannan tasirin ta hana CRH da sakin ACTH.
4.Ayyukan Neuroprotective da Reparative
DSIP ya nuna kaddarorin neuroprotective da gyaran gyare-gyare waɗanda ke wakiltar wani muhimmin al'amari na yuwuwar warkewarta..
Ya nuna wa'adi ga magani na cututtuka na neurodegenerative , a tsakanin sauran sharudda.
COA
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