Ultrasensitive tumour-penetrating nanosensors nke ọrụ protease

Ikike iji chọpụta ọnya ọrịa kansa na endogenous biomarkers bụ naanị etuto ~ 1 cm n'obosara. N'oge na-adịbeghị anya, anyị kọrọ otu nanosensor tumor-penetrating nanosensor na-awụfu, na nzaghachi nke akpụ-kpọmkwem proteases, Iberibe peptide nke enwere ike ịchọpụta na mmamịrị. Ebe a, anyị na-akọ njikarịcha, ihe nlereanya mgbakọ na mwepụ pharmacokinetic kọwapụtara ya, Ngosipụta elu nke mkpụrụ peptide na-eme ka ha abụọ kwalite mgbawa protease a na-eche na-eche ma wedata nhụsianya a na-achọghị., na nke na-arụ ọrụ nke nanosensors na tumor-penetrating ligands nke na-eme ka ụzọ ịzụ ahịa na-arụ ọrụ na-eme ka mmụba na microenvironment tumor.. Nanosensor nke si na ya pụta kpasuru oke ọnya sub-5 mm na etuto epithelial mmadụ wee chọpụta nodules nwere dayameta etiti dị obere karịa. 2 mm n'ụdị orthotopic nke ọrịa cancer ovarian. Anyị na-egosipụtakwa nkọwapụta nke usoro mgbaama dabere na mmamịrị n'ụdị immunocompetent nke colorectal imeju metastases., na n'ọnọdụ ịgbalite nanosensors na microarrays tumor mmadụ mgbe emegharịrị ya dị ka nyocha fluorogenic zymography..