Mgbanwe C-Terminal Peptide na-ekpughe ọrụ ozugbo na nke na-apụtaghị ìhè nke Hedgehog Morphogen Cholesteroylation.

Hedgehog (Hh) morphogens na-etinye aka na mmepe embrayo na ihe ọmụmụ sel stem na, ma ọ bụrụ na ezighi ezi, nwere ike itinye aka na ọrịa kansa. Otu mgbanwe dị mkpa na ntụgharị ntụgharị nwere mmetụta dị ukwuu na Hh biofunction bụ cholesteroylation C-terminal ya n'oge biosynthesis.. Echiche a na-ekwu ugbu a bụ na mkpụrụ ndụ cholesterol bụ ihe dị mkpa na njikọ Hh na mpempe akwụkwọ akpụkpọ anụ plasma nke na-emepụta mkpụrụ ndụ., cell-elu Hh multimerization, na njem ya na akara ngosi ya. Ma, A naghị ekpebi ma akụkụ cholesterol na-etinye aka na usoro ndị a niile, N'ihi na njikọta ọrụ ha na-ebuli ohere ọzọ na cholesterol na-amalite usoro mmalite ozugbo yana na usoro ndị a nwere ike iduzi usoro nke Hh na-esote nke na-egosi na-adabereghị na lipid.. Anyị mepụtara ụdị dị iche iche nke C-terminal Hh peptide wee hụ na peptides cholesteroylated ndị a na-emebi ọtụtụ usoro ntụgharị okwu n'imepụta mkpụrụ ndụ na Hh biofunction na Drosophila melanogaster anya na mmepe nku.. Anyị chọpụtakwara na nnukwu ego Hh kewapụrụ na mkpado peptide cholesteroylated in vitro na in vivo na nke akara Hh dị iche iche enweghị akara C-cholesterol ha nọgidere na-arụ ọrụ.. Ụzọ anyị si egosi na Hh cholesteroylation dị mkpa n'oge mmalite nke mmepụta Hh na maturation mana ọ na-atụkwa aro na ọ ga-ewepụ ya maka nnabata Hh na-enweta sel..