Glycinamide hydrochloride

I. Peptides na nyocha ihe omimi nke ihe omimi

1. Ihe mgbochi ụlọ nke C-Terminal maka Peptides
Ngwakọta peptide siri ike-phase/mmiri-phase, gụnyere C-terminal glycine amide (-Gly–NH₂). Ọtụtụ peptides bioactive chọrọ mgbanwe amide C-terminal iji kwalite iguzogide proteolysis ma melite biostability.; free glycine amide na-adịkarị mfe imebi, ebe nnu hydrochloride ya bụ anụ ụlọ, Akụrụngwa enwere ike iji ya mee ihe maka njikọ peptide na iwu ụlọ ọba akwụkwọ peptide.
2. Nyocha bioconjugation na Protein mgbanwe
Nwere otu amine praịmarị n'efu nwere ike ijikọ na otu ndị na-arụ ọrụ dịka NHS esters, na-eje ozi dị ka ihe atụ maka akara protein na fluorescent otu.
3. Ihe mmalite maka Heterocyclic na Metal Complex Synthesis

– Njikọ nke imidazolidine-4-otu na ogige diazaspiro;
– Nkwadebe nke ogige Ir na Rh organometallic luminescent maka ojiji na photochemistry na nyocha fotocatalysis..

II. Nnwale biochemical: Ihe nchekwa pH nke anụ ahụ

pKa ≈ 8.20, Oke nchekwa dị irè 7.2–9.2; nkewa dị ka “Ezigbo” sistemụ nchekwa:

– Nyochaa ọrụ nke enzymes: Kwesịrị ekwesị maka nnwale kinetics enzyme n'okpuru ọnọdụ obere alkaline;
– Nchekwa maka omenala in vitro cell; Kwadebe ngwọta ngwaahịa site na sterilizing site na 0.22 μm filtration;
– Usoro ngwọta protein: Mmiri na-agbaze nke ukwuu, dakọtara na ọtụtụ protein, na eguzogide mmiri ozuzo protein.

III. Ọkpụkpụ Tissue / Stem Cell Biology (Isiokwu na-ekpo ọkụ na nso nso a)

1. Nhazi nke Protein-Glycinamide Nanocomposites
Ndị nanocomposites ndị a na-akwụ ụgwọ nke ọma na-agbakọta n'ime submicron nanoparticles site na mmekọrịta electrostatic na protein ndị ebubo na-adịghị mma. (BSA, BMP-2), na-eme ka mmepụta protein dị mma site na mkpụrụ ndụ na imeziwanye nnyefe intracellular nke protein recombinant..
2. Mmekọrịta mmekọrịta nke Osteogenic iche na BMP-2
Na-akwalite mkpụrụ ndụ ihe nrịbama osteogenic dị ka Runx2, ALP, na Col1a1; na-akwalite ọrụ alkaline phosphatase na njikọ collagen; ụdị ntụpọ cranial òké na-akwado nkwalite mmekọrịta nke in vivo ọkpụkpụ ọhụrụ, ọdabara maka ihe nrụzi ọkpụkpụ na nyocha nke usoro nhazi ọkpụkpụ (PMC).

IV. Sistemụ Nlereanya Ọkpụkpọ anụ ahụ na Melanocyte (PMC)

Ụzọ nrịbama n'ụdị nyocha:
Na-egbochi nrịbama α-MSH kpatara, na-ebelata MITF na tyrosinase (TYR) okwu, ma na-ebelata mmepụta nke melanin;
Ejiri ya mee nyocha maka ịchacha akpụkpọ ahụ na usoro pigmentation; enwere ntakịrị ọnụọgụ in vitro na ọmụmụ mmadụ nke mbido, ma ọ ka dị anya site n'ịghọ ngwaahịa ọgwụ ma ọ bụ ihe ịchọ mma emechara ma bụrụ naanị na nyocha nyocha..

V. Enzyme na Metabolic Pathway Ngwa Ngwa Ngwa / Analogs

1. Analogs structural glycine, A na-eji amụ njem amino acid na usoro nnabata amino acid yist;
2. Ihe nyocha analog arụpụtara maka ụzọ njikọ purine (ịmata ọdịiche GAR [glycinyl-adenosyl-ribonucleotide]), na-enyere aka n'ịkọwa njirimara mkpụrụ na saịtị na-arụ ọrụ nke enzymes biosynthetic purine.

VI. Nnyocha bụ isi na Chemistry ọgwụ

Dị ka sịntetik ụlọ blocks:

– Isi ụlọ nyocha-njikwa precursors maka ọgwụ neuroprotective dị ka oracitane;
– Ewu nke heterocyclic molecular ọba akwụkwọ nke pyrazines na imidazoles maka nyocha ogige obere lead..

Ihe ndị dị mkpa maka iji nyocha

1. Nnukwu hygroscopic; tụọ ma kwadebe ngwọta ngwa ngwa; kwadebe aqueous ngwọta ọhụrụ mgbe ọ bụla o kwere omume;
2. Buffers chọrọ mmezi pH ziri ezi na NaOH/HCl, sochiri filtration na sterilization;
3. Maka nnwale ndu, gụnyere otu njikwa glycine iji mata ọdịiche dị iche iche nke otu amide kpatara.